Gene regulation by retroelement encoded natural antisense transcripts

通过逆转录元件编码的天然反义转录物进行基因调控

• 批准号: DP210103811
• 负责人: A/Prof Cecile King
• 金额: $ 64.99万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103811
• 关键词: Gene; regulation; retroelement; encoded; natural

Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes. Expected Outcomes and Benefits: This proposal will provide novel targets and methodology for gene modulation with broad applications from biology to environmental sciences.

遗传信息是地球上所有生命的基础，并被加工成蛋白质，蛋白质决定了生物体的特征。然而，我们的整个基因组中只有大约2%是由编码蛋白质的基因组成的;其他98%是非编码的，其功能仍然知之甚少。目的和意义：该提案旨在利用尖端的基因组技术来产生关于非编码基因组如何调节蛋白质编码基因表达的新知识。预期成果和效益：这一提议将为基因调控提供新的靶点和方法，具有从生物学到环境科学的广泛应用。