Body Iron and Mental Health-Related Outcomes in Adolescents: A NHANES Data Analysis

项目摘要 许多精神疾病，从重度抑郁症到物质使用和犯罪， 或在青春期恶化。这些疾病相当普遍，并与实质性的痛苦有关， 损伤它们危及一个人走向富有成效的成年的轨迹，并增加自杀风险， 参与犯罪。因为青春期的特点是剧烈的身体发育， 对于女性月经来说，这个关键的发育时期也与缺铁的风险增加有关 （ID）.铁缺乏与神经精神损害有关，包括抑郁和注意力 缺陷多动症状。这并不奇怪，因为铁在树突状线粒体运动中的作用， 海马神经元发育、单胺能信号传导和髓鞘形成。事实上，在独立的 其他医学健康的青少年样本，我们发现普遍的ID和负相关 铁储备和精神症状的严重程度之间的关系。此外，我们的初步证据表明， 身体铁储存与大脑形态和连接有关，如磁共振所捕获的 显像这项工作已经导致了R 01奖（1 R 01 MH 124848），以进一步研究如何身体铁储存 与脑铁储存、脑功能和精神病理学有关。 只有少数研究检查了身体铁储存和精神病理学之间的联系， 青少年和那些受到严重限制的人。小额赠款（R 03）申请 寻求资金，以使用来自国家健康和营养调查的几波数据 （NHANES）。鉴于可获得关于大量 青少年（~900/波），用于身体铁储存、抑郁症状、注意力不集中、物质 使用、性活动和性传播感染。因此，我们将检查体内铁的含量 有抑郁症状（目标1a）和外化行为综合评分（目标1b）的商店。更 重要的是，我们还试图确定身体铁储存的水平， 行为出现（目标2）。这一点至关重要，因为ID是由医疗领域根据以下内容定义的： 贫血相关的结果;然而，临床前和临床数据表明，脑铁在贫血之前耗尽 出现了 总之，利用几个NHANES数据波，该提案将是第一个检查临床 在一个大的青少年群体的身体铁储存的相关因素，占各种混杂因素。而且 通过强调ID的神经精神影响， 人体铁储存量高于迄今为止被认为是医学上有问题的，需要补充。

Project Summary Many psychiatric disorders, ranging from major depressive disorder to substance use and delinquency, emerge or worsen during adolescence. These disorders are quite prevalent and associated with substantial distress and impairment. They jeopardize one's trajectory towards a productive adulthood, and increase suicide risk and involvement in crime. Because adolescence is characterized by dramatic physical development and the onset of menses in females, this critical developmental period is also associated with increased risk for iron deficiency (ID). Iron deficiency has been associated with neuropsychiatric impairment, including depressive and attention deficit hyperactivity symptoms. This is not surprising, given iron's role in dendritic mitochondrial motility during hippocampal neuron development, monoaminergic signaling, and myelination. In fact, across independent samples of otherwise medically-healthy adolescents, we have found prevalent ID and an inverse association between iron stores and the severity of psychiatric symptoms. Moreover, our preliminary evidence suggests that body iron stores are associated with brain morphometry and connectivity, as captured by magnetic resonance imaging. This work has resulted in a R01 award (1 R01 MH124848) to further examine how body iron stores relate to brain iron stores, brain function, and psychopathology. Only a few studies have examined the association between body iron stores and psychopathology in adolescents and those that have suffer from substantial limitations. As such, this Small Grant (R03) application seeks funding to use several waves of data from the National Health and Nutrition Examination Survey (NHANES). This data set offers a unique opportunity given the availability of information on a large number of adolescents (~900/wave) for several markers of body iron stores, depressive symptoms, inattention, substance use, sexual activity, and sexually transmitted infections. As such, we will be examine the association of body iron stores with depressive symptoms (Aim 1a) and with a composite score of externalizing behavior (Aim 1b). More importantly, we also seek to determine the level of body iron stores at which problematic mental health-related behaviors emerge (Aim 2). This is critical given that the ID has been defined by the medical field based on anemia-related outcomes; however, preclinical and clinical data suggest that brain iron is depleted before anemia emerges. In sum, taking advantage of several NHANES data waves, this proposal will be the first to examine the clinical correlates of body iron stores in a large group of adolescents, accounting for various confounders. Moreover, it has the potential to make a substantial impact on the field by highlighting ID's neuropsychiatric effects at levels of body iron stores higher than what has so far been considered medically problematic, requiring repletion.