Body Iron and Mental Health-Related Outcomes in Adolescents: A NHANES Data Analysis

青少年身体铁和心理健康相关结果：NHANES 数据分析

• 批准号: 10284286
• 负责人: Chadi A. Calarge
• 金额: $ 9.12万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10284286
• 关键词: 17 year old; Accounting; Adolescence; Adolescent; Adult; Anemia; Antipsychotic Agents; Anxiety Disorders; Attention deficit hyperactivity disorder; Attentional deficit; Award; Basal Ganglia; Behavior; Blood; Bone Marrow; Brain; Child; Childhood; Clinical; Clinical Data; Crime; Data; Data Analyses; Data Set; Depressive disorder; Development; Diagnosis; Disease; Distress; Enzymes; Erythrocytes; Female; Female Adolescents; Female of child bearing age; Ferritin; Funding; Grant; Growth; Guidelines; Health; Health Surveys; Health behavior; Hemoglobin; Hippocampus (Brain); Hyperactivity; Impaired cognition; Impairment; Impulse Control Disorders; Intervention; Iron; Link; MRI Scans; Magnetic Resonance Imaging; Maintenance; Major Depressive Disorder; Male Adolescents; Measures; Medical; Menstruation; Mental Health; Mental disorders; Metabolism; Mitochondria; National Health and Nutrition Examination Survey; Neuraxis; Nutrition Surveys; Organ; Outcome; Oxygen; Pathological anxiety; Patients; Peripheral; Pharmaceutical Preparations; Play; Predisposition; Production; Psychopathology; Publishing; Questionnaires; Resistance; Risk; Risperidone; Role; Sample Size; Sampling; Serum; Severities; Sex Behavior; Sexually Transmitted Diseases; Signal Transduction; Structure; Substance abuse problem; Sum; Symptoms; Tissues; Weight Gain; Work; adverse outcome; anxiety symptoms; base; cell motility; cofactor; critical developmental period; depressive symptoms; externalizing behavior; inattention; indexing; innovation; iron deficiency; micronutrient deficiency; morphometry; myelination; neuron development; neuropsychiatry; pre-clinical; psychiatric symptom; single episode major depressive disorder; substance use; suicidal risk

Project Summary Many psychiatric disorders, ranging from major depressive disorder to substance use and delinquency, emerge or worsen during adolescence. These disorders are quite prevalent and associated with substantial distress and impairment. They jeopardize one's trajectory towards a productive adulthood, and increase suicide risk and involvement in crime. Because adolescence is characterized by dramatic physical development and the onset of menses in females, this critical developmental period is also associated with increased risk for iron deficiency (ID). Iron deficiency has been associated with neuropsychiatric impairment, including depressive and attention deficit hyperactivity symptoms. This is not surprising, given iron's role in dendritic mitochondrial motility during hippocampal neuron development, monoaminergic signaling, and myelination. In fact, across independent samples of otherwise medically-healthy adolescents, we have found prevalent ID and an inverse association between iron stores and the severity of psychiatric symptoms. Moreover, our preliminary evidence suggests that body iron stores are associated with brain morphometry and connectivity, as captured by magnetic resonance imaging. This work has resulted in a R01 award (1 R01 MH124848) to further examine how body iron stores relate to brain iron stores, brain function, and psychopathology. Only a few studies have examined the association between body iron stores and psychopathology in adolescents and those that have suffer from substantial limitations. As such, this Small Grant (R03) application seeks funding to use several waves of data from the National Health and Nutrition Examination Survey (NHANES). This data set offers a unique opportunity given the availability of information on a large number of adolescents (~900/wave) for several markers of body iron stores, depressive symptoms, inattention, substance use, sexual activity, and sexually transmitted infections. As such, we will be examine the association of body iron stores with depressive symptoms (Aim 1a) and with a composite score of externalizing behavior (Aim 1b). More importantly, we also seek to determine the level of body iron stores at which problematic mental health-related behaviors emerge (Aim 2). This is critical given that the ID has been defined by the medical field based on anemia-related outcomes; however, preclinical and clinical data suggest that brain iron is depleted before anemia emerges. In sum, taking advantage of several NHANES data waves, this proposal will be the first to examine the clinical correlates of body iron stores in a large group of adolescents, accounting for various confounders. Moreover, it has the potential to make a substantial impact on the field by highlighting ID's neuropsychiatric effects at levels of body iron stores higher than what has so far been considered medically problematic, requiring repletion.

项目摘要 许多精神疾病，从重度抑郁症到吸毒和犯罪，出现 或在青春期恶化。这些疾病非常普遍，并且与实质性的困扰有关 损害。他们危害一个人对成年生产的轨迹，并增加自杀风险和 参与犯罪。因为青春期的特征是戏剧性的身体发育和发作 在女性的月经中，这个关键的发育时期也与铁缺乏症的风险增加有关 （ID）。铁缺乏症与神经精神障碍有关，包括抑郁和注意力 赤字多动症症状。鉴于铁在树突状线粒体运动中的作用，这并不奇怪 海马神经元发育，单胺能信号传导和髓鞘形成。实际上，跨独立 原本有医学健康的青少年的样本，我们发现了普遍的ID和逆关联 在铁储存和精神症状的严重性之间。此外，我们的初步证据表明 人体铁储存与脑形态计量学和连通性有关，如磁共振捕获 成像。这项工作已获得R01奖（1 R01 MH124848），以进一步研究身体铁店的方式 与脑铁存储，脑功能和精神病理学有关。 只有少数研究检查了人体铁店与心理病理学之间的关联 青少年和那些受到重大限制的人。因此，这个小赠款（R03）申请 寻求资金使用来自国家健康和营养检查调查中的几种数据浪潮 （nhanes）。鉴于大量信息的可用性，该数据集提供了一个独特的机会 青少年（〜900/Wave），用于体铁储存的几种标记，抑郁症状，注意力不集中，物质 使用，性活动和性传播感染。因此，我们将检查身体铁的关联 具有抑郁症状的存储（AIM 1A）和外在行为的综合评分（AIM 1B）。更多的 重要的是，我们还试图确定与心理健康有关的人体铁店的水平 出现行为（目标2）。鉴于ID已由医疗领域定义的ID至关重要 与贫血有关的结果；然而，临床前和临床数据表明，脑铁在贫血前耗尽 出现。 总而言之，利用几个NHANES数据波，该提案将是第一个检查临床的建议 大量青少年中的人体铁储存的相关性，占各种混杂因素。而且，它 有可能通过突出ID的神经精神效果来对该领域产生重大影响 人体铁的存储量高于迄今为止被认为是医学上有问题的，需要补充。