Body Iron and Mental Health-Related Outcomes in Adolescents: A NHANES Data Analysis

项目摘要 出现了许多精神障碍，从严重的抑郁障碍到药物使用和犯罪。 或在青春期恶化。这些障碍相当普遍，并与严重的痛苦和 减损。它们危及一个人迈向富有成效的成年的轨迹，并增加自杀风险和 参与犯罪。因为青春期的特点是戏剧性的身体发育和发病 对于女性的月经，这一关键的发育期也与缺铁的风险增加有关。 (ID)。缺铁与神经精神损害有关，包括抑郁和注意力集中。 缺乏性多动症状。这并不令人惊讶，因为铁在树突状线粒体运动中的作用 海马神经元发育、单胺能信号和髓鞘形成。事实上，在独立的 在其他方面健康的青少年样本中，我们发现了流行的ID和相反的关联 铁储备和精神症状的严重程度之间的关系。此外，我们的初步证据表明 正如磁共振所捕捉到的，体内铁的储存与大脑的形态测量和连通性有关 成像。这项工作已经产生了R01奖(1 R01 MH124848)，以进一步研究身体铁是如何储存的 与大脑铁储存、大脑功能和精神病理学有关。 只有几项研究检查了体内铁储存与精神病理之间的关系 青少年和那些遭受严重限制的人。因此，这份小额赠款(R03)申请 寻求资金使用国家健康和营养检查调查的几波数据 (NHANES)。这一数据集提供了一个独特的机会，因为有关于大量 青少年(约900次/波)身体铁储存的几个标志，抑郁症状，注意力不集中，物质 使用、性行为和性传播感染。因此，我们将研究体内铁的关联 有抑郁症状的商店(目标1a)和外化行为的综合得分(目标1b)。更多 重要的是，我们还试图确定与心理健康有关的有问题的身体铁的储存水平 行为显现(目标2)。这一点很重要，因为ID已由医疗领域根据 与贫血相关的结果；然而，临床前和临床数据表明，脑铁在贫血之前就被耗尽了。 出现了。 总而言之，利用几个NHANES数据波，这项提议将是第一个检查临床 在一大群青少年中，身体铁储存的相关性，解释了各种混杂因素。此外，它还 通过在一定程度上强调ID的神经精神影响，有可能在该领域产生重大影响 体内铁的储存量高于迄今被认为存在医学问题的水平，需要重新补充。

Project Summary Many psychiatric disorders, ranging from major depressive disorder to substance use and delinquency, emerge or worsen during adolescence. These disorders are quite prevalent and associated with substantial distress and impairment. They jeopardize one's trajectory towards a productive adulthood, and increase suicide risk and involvement in crime. Because adolescence is characterized by dramatic physical development and the onset of menses in females, this critical developmental period is also associated with increased risk for iron deficiency (ID). Iron deficiency has been associated with neuropsychiatric impairment, including depressive and attention deficit hyperactivity symptoms. This is not surprising, given iron's role in dendritic mitochondrial motility during hippocampal neuron development, monoaminergic signaling, and myelination. In fact, across independent samples of otherwise medically-healthy adolescents, we have found prevalent ID and an inverse association between iron stores and the severity of psychiatric symptoms. Moreover, our preliminary evidence suggests that body iron stores are associated with brain morphometry and connectivity, as captured by magnetic resonance imaging. This work has resulted in a R01 award (1 R01 MH124848) to further examine how body iron stores relate to brain iron stores, brain function, and psychopathology. Only a few studies have examined the association between body iron stores and psychopathology in adolescents and those that have suffer from substantial limitations. As such, this Small Grant (R03) application seeks funding to use several waves of data from the National Health and Nutrition Examination Survey (NHANES). This data set offers a unique opportunity given the availability of information on a large number of adolescents (~900/wave) for several markers of body iron stores, depressive symptoms, inattention, substance use, sexual activity, and sexually transmitted infections. As such, we will be examine the association of body iron stores with depressive symptoms (Aim 1a) and with a composite score of externalizing behavior (Aim 1b). More importantly, we also seek to determine the level of body iron stores at which problematic mental health-related behaviors emerge (Aim 2). This is critical given that the ID has been defined by the medical field based on anemia-related outcomes; however, preclinical and clinical data suggest that brain iron is depleted before anemia emerges. In sum, taking advantage of several NHANES data waves, this proposal will be the first to examine the clinical correlates of body iron stores in a large group of adolescents, accounting for various confounders. Moreover, it has the potential to make a substantial impact on the field by highlighting ID's neuropsychiatric effects at levels of body iron stores higher than what has so far been considered medically problematic, requiring repletion.