Examining the Skeletal Effects of Psychostimulants
检查精神兴奋剂对骨骼的影响
基本信息
- 批准号:10439840
- 负责人:
- 金额:$ 60.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-20 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:11 year old16 year old17 year old19 year oldAccountingAdolescentAdolescent and Young AdultAffectAftercareAgeAmphetaminesAntipsychotic AgentsAttention deficit hyperactivity disorderBone DensityBone Mineral ContentsBone ResorptionChildChronicConfounding Factors (Epidemiology)Control GroupsCross-Sectional StudiesDataData SetDevelopmentDiagnosisDistalDoseDrug PrescriptionsDual-Energy X-Ray AbsorptiometryEnrollmentFailureFamilyFemaleFundingGrowthHeightHip region structureImpairmentInterventionKnowledgeLifeLongitudinal StudiesLongitudinal observational studyMasksMediatingMedicalMineralsMonitorNational Health and Nutrition Examination SurveyNeckObservational StudyOsteoclastsOutcomeParticipantPatientsPeripheralPharmaceutical PreparationsPhysical activityPolypharmacyPrevalenceProspective StudiesPsychopathologyPubertyPublishingRaceRadialRattusResolutionRiskRisperidoneRitalinScanningSelective Serotonin Reuptake InhibitorVertebral columnVitamin DX-Ray Computed Tomographyage groupbasebonebone fragilitybone massbone qualitybone strengthboyscalcium intakeclinically significantcomparison groupcortical bonecritical developmental perioddesignfracture riskgirlsmalemedication safetypre-clinical researchpreferenceprepubertyprospectivepsychostimulantsecondary analysissexskeletalstimulant usesubstantia spongiosatibiayoung adult
项目摘要
PROJECT SUMMARY
Psychostimulants used to treat attention deficit hyperactivity disorder (ADHD) are the second most
prescribed medication class for long-term use in children and adolescents. These medications have long been
known to impede linear growth, however, recent preclinical research has shown that they also reduce
appendicular bone mineral content (BMC) and bone quality in young rats. This is mediated by an increase in
osteoclast differentiation and activity, promoting bone resorption. In children and adolescents, the use of
psychostimulants has also been associated with clinically significant lower dual-energy x-ray absorptiometry
(DXA)-based BMC and areal bone mineral density (aBMD) at the lumbar spine (LS) and hip, in a dose-
dependent manner. In addition, our group has found that boys chronically-treated with psychostimulants may
have lower LS aBMD velocity Z-scores compared to those not taking psychostimulants.
Given that bone mass accrued by young adulthood may determine fracture risk later in life, this application
seeks to examine the skeletal effects of psychostimulants in children and adolescents and examine whether
sex and pubertal development are significant moderators. Specifically, we propose to enroll otherwise
medically healthy 7 to 16 year-olds within one month of starting psychostimulants and unmedicated. In this
observational study, we will monitor skeletal outcomes over a one-year period, with repeated DXA and high-
resolution pQCT (HRpQCT) scans, along with a thorough assessment of psychopathology and of factors
known to affect bone mineral accrual. This design will allow us to prospectively asses the effects of
psychostimulants on bone mass accrual and bone microarchitecture in children and adolescents (Aim 1).
Given that peak bone accrual velocity in boys is nearly double that in girls and that that bone mass increases
exponentially during puberty, we also seek to evaluate whether sex and stages of sexual maturity moderate
this effect (Aim 2). Secondary analyses will examine the impact of these medications on additional DXA- and
HRpQCT-based outcomes.
This study will be the first to prospectively examine whether psychostimulants impair bone mineral accrual
during purberty, increasing one's risk for low bone mass later in life. This information is key to designing
appropriate interventions to mitigate this risk and to helping clinicians and families make informed decisions
about treatment options most suitable for the patient's needs.
项目总结
用于治疗注意缺陷多动障碍(ADHD)的精神刺激剂排在第二位
儿童和青少年长期使用的处方药物类别。长期以来,这些药物一直是
然而,已知会阻碍线性增长,最近的临床前研究表明,它们也会减少
幼年大鼠附件骨矿物质含量与骨质量的关系。这是由增加的
破骨细胞分化活跃,促进骨吸收。在儿童和青少年中,使用
心理刺激剂也与临床上较低的双能x射线吸收测量法有关。
基于(DXA)的BMC和腰椎(LS)和髋部的面骨密度(ABMD),在一定剂量-
依赖的态度。此外,我们小组发现,长期接受精神刺激剂治疗的男孩可能会
与不服用精神刺激剂的人相比,有较低的LS aBMD速度Z得分。
考虑到青壮年积累的骨量可能决定晚年的骨折风险,这一应用程序
旨在研究精神刺激剂对儿童和青少年的骨骼影响,并检查
性和青春期发育是重要的调节因素。具体地说,我们建议以其他方式注册
身体健康的7至16岁的儿童,在服用精神刺激剂后一个月内不服药。在这
观察性研究,我们将在一年内监测骨骼结果,重复DXA和高-
分辨率pQCT(HRpQCT)扫描,以及对精神病理学和因素的彻底评估
已知会影响骨矿物质的积累。这一设计将使我们能够前瞻性地评估
心理刺激剂对儿童和青少年骨量增加和骨微结构的影响(目标1)。
鉴于男孩的骨峰值速度几乎是女孩的两倍,而且骨量增加
在青春期,我们还试图评估性行为和性成熟阶段是否适中
此效果(目标2)。二次分析将检查这些药物对额外的DXA-和
基于HRpQCT的结果。
这项研究将首次前瞻性地研究精神刺激剂是否会损害骨矿物质的积累。
在青春期,增加了一个人在晚年患低骨量的风险。这些信息是设计的关键
适当的干预措施,以减少这种风险,并帮助临床医生和家庭做出明智的决定
关于最适合患者需求的治疗方案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chadi A. Calarge其他文献
10.4 THE EFFECT OF SSRIS ON LONGITUDINAL GROWTH
- DOI:
10.1016/j.jaac.2021.07.611 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Chadi A. Calarge - 通讯作者:
Chadi A. Calarge
10.3 IRON DEFICIENCY AND INTERNALIZING DISORDERS IN ADOLESCENTS
- DOI:
10.1016/j.jaac.2020.07.607 - 发表时间:
2020-10-01 - 期刊:
- 影响因子:
- 作者:
Chadi A. Calarge - 通讯作者:
Chadi A. Calarge
5.33 CENTRAL KYNURENINE PATHWAY IN DEPRESSION IN YOUNG ADULTS: RELEVANCE TO SUICIDALITY
- DOI:
10.1016/j.jaac.2016.09.292 - 发表时间:
2016-10-01 - 期刊:
- 影响因子:
- 作者:
Chadi A. Calarge;Cristian Coarfa;Sridevi Devaraj;Vivekananda Shetty - 通讯作者:
Vivekananda Shetty
THE GUT MICROBIOTA IN AUTISM SPECTRUM DISORDER: FROM BENCH TO BEDSIDE
- DOI:
10.1016/j.jaac.2020.07.651 - 发表时间:
2020-10-01 - 期刊:
- 影响因子:
- 作者:
Chadi A. Calarge;James T. McCracken - 通讯作者:
James T. McCracken
4.26 The Effects of Fluoxetine and Sertraline on Height and Weight During Puberty
- DOI:
10.1016/j.jaac.2023.09.270 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
Chima N. Amushie;Stephanie Dinh;James Mills;Griselda Barba Villalobos;Jacqueline Nguyen;Sridevi Devaraj;Fida Bacha;Chadi A. Calarge - 通讯作者:
Chadi A. Calarge
Chadi A. Calarge的其他文献
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{{ truncateString('Chadi A. Calarge', 18)}}的其他基金
Body Iron and Mental Health-Related Outcomes in Adolescents: A NHANES Data Analysis
青少年身体铁和心理健康相关结果:NHANES 数据分析
- 批准号:
10284286 - 财政年份:2021
- 资助金额:
$ 60.48万 - 项目类别:
Examining the Skeletal Effects of Psychostimulants
检查精神兴奋剂对骨骼的影响
- 批准号:
10242711 - 财政年份:2020
- 资助金额:
$ 60.48万 - 项目类别:
Examining the Skeletal Effects of Psychostimulants
检查精神兴奋剂对骨骼的影响
- 批准号:
10653823 - 财政年份:2020
- 资助金额:
$ 60.48万 - 项目类别:
Iron Deficiency and Brain Development in Youth with Internalizing Disorders
患有内化障碍的青少年缺铁和大脑发育
- 批准号:
10478058 - 财政年份:2020
- 资助金额:
$ 60.48万 - 项目类别:
Iron Deficiency and Brain Development in Youth with Internalizing Disorders
患有内化障碍的青少年缺铁和大脑发育
- 批准号:
10099487 - 财政年份:2020
- 资助金额:
$ 60.48万 - 项目类别:
Iron Deficiency and Brain Development in Youth with Internalizing Disorders
患有内化障碍的青少年缺铁和大脑发育
- 批准号:
10265539 - 财政年份:2020
- 资助金额:
$ 60.48万 - 项目类别:
Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
青少年利培酮治疗的长期安全性和遗传风险因素
- 批准号:
8033328 - 财政年份:2010
- 资助金额:
$ 60.48万 - 项目类别:
Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
青少年血清素再摄取抑制剂和骨矿化
- 批准号:
8663307 - 财政年份:2010
- 资助金额:
$ 60.48万 - 项目类别:
Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
青少年血清素再摄取抑制剂和骨矿化
- 批准号:
7993410 - 财政年份:2010
- 资助金额:
$ 60.48万 - 项目类别:
Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
青少年血清素再摄取抑制剂和骨矿化
- 批准号:
8458139 - 财政年份:2010
- 资助金额:
$ 60.48万 - 项目类别:
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