Biomarkers of Dietary Intake and Exposure Data Coordinating Center

项目摘要/摘要 饮食生物标记物发展中心(DBDC)联盟的目的是确定 饮食摄入量的生物标志物，可作为饮食摄入量的独立标志物 补充目前的膳食摄入量评估方法和不断发展的证据 解决膳食成分代谢转化的基础，特别是非 寄主和微生物代谢的营养物质。数据协调中心(DCC)的目标是：1) 提供强大的行政管理结构，以增强沟通和 协作并提高DBDC联盟的工作效率和质量，2)提供数据 转移、协调、整合、处理和管理，3)开发自助服务 为用户提供分析平台和互动报告并进行分析，以及4)沟通 并在联盟内外传播知识。在行动上，DCC将 编写操作手册，提供礼仪培训，建立和监测时间表， 组织与指导委员会(SC)、NIDDK/USDA以及数据安全和 监控板(DSMB)。对于数据管理，DCC将建立符合联邦标准的 在线电子数据捕获系统，支持数据的直接提交和基于Web的 联盟通信和协作平台(CCCP)，用于安全数据共享和 传播工具和成果。CCCP将提供访问自助服务的链接 分析和交互式报告，便于轻松访问数据。DCC将定期 评估数据质量、执行数据完整性检查、开发数据文档、 确保保护患者的机密性，为SC和DSMB准备报告，并准备 未识别的公共用途数据文件，用于提交到NIDDK储存库。最后，DCC将 提供思想领导力、生物统计学支持和方法创新，以说明 饮食生物标记物开发的多面性，并有助于制备和 通过多份影响较大的手稿和演示文稿传播研究成果。我们的 团队在数据管理、协调和协调方面的全国公认的专业知识 庞大的网络，以及我们在生物标记物研究方面的经验，将DCRI定位为 提供财团所需的所有服务和支持。

Project Summary/Abstract The purpose of the Dietary Biomarker Development Centers (DBDCs) Consortium is to identify biomarkers of dietary intake that can serve as independent markers of dietary intake and complement current dietary intake assessment methods and the continually evolving evidence base for addressing metabolic transformation of dietary constituents, especially the non- nutrients by host and microbial metabolism. The Data Coordinating Center (DCC) aims to: 1) provide a robust administrative management structure that enhances communication and collaboration and improves the DBDC’s Consortium productivity and quality, 2) provide data transfers, harmonization, integration, processing, and management, 3) develop a self-service analytics platform and interactive reporting for users and conduct analyses, and 4) communicate and disseminate knowledge within and beyond the Consortium. Operationally, the DCC will develop manuals of operations, provide protocol training, establish and monitor timelines, organize meetings with the Steering Committee (SC), NIDDK/USDA, and Data Safety and Monitoring Board (DSMB). For data management, the DCC will establish a federally-compliant online electronic data capture system to support the direct submission of data and a web-based consortium communication and collaboration platform (CCCP) for secure data sharing and dissemination of tools and results. The CCCP will have a link to access the self-service analytics and interactive reporting to facilitate easy access to the data. The DCC will periodically assess data quality, perform checks for data completeness, develop data documentation, ensure protection of patient confidentiality, prepare reports for the SC and DSMB, and prepare de-identified public use data files for submission into the NIDDK repository. Finally, the DCC will provide thought leadership, biostatistical support, and methodological innovation to account for the multi-faceted nature of dietary biomarker development, and facilitate the preparation and dissemination of study results through multiple high-impact manuscripts and presentations. Our team’s nationally recognized expertise in data management, harmonization, and coordination of large networks, and our experience in biomarker research uniquely positions the DCRI to provide all of the services and support required by the Consortium.