The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination

IGNITE II CC：参与、协调、示范和传播

• 批准号: 10330314
• 负责人: Hrishikesh Chakraborty
• 金额: $ 36.74万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-22 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10330314
• 关键词: Address; Award; Biological Markers; Body mass index; COVID-19; COVID-19 pandemic; Career Choice; Childhood; Cohort Studies; Collaborations; Collection; Colorectal Cancer; Communication; Communities; Contracts; Country; Data Analyses; Data Collection; Development; Education; Effectiveness; Elderly; Epidemiology; Evaluation; Faculty; Funding; Genetic; Genomic medicine; Genomics; Geography; Goals; Health Sciences; Individual; Information Dissemination; International; Interview; Knowledge; Leadership; Learning; Logistics; Malignant Neoplasms; Measures; Mental Health; Mentorship; Methods; National Human Genome Research Institute; Obesity; Opioid; Participant; Peer Review; PhenX Toolkit; Phenotype; Population; Population Study; Positioning Attribute; Predisposition; Process; Program Development; Public Health; Research; Research Personnel; Research Support; Resources; Role; SARS-CoV-2 infection; Sample Size; Sampling; Science; Series; Site; South Africa; Standardization; Students; Surveys; Trust; Underrepresented Populations; United States National Institutes of Health; Universities; Work; adverse outcome; catalyst; clinical practice; cohort; data standards; diversity and inclusion; emerging adult; experience; faculty mentor; improved; infancy; interest; low and middle-income countries; member; metabolomics; mortality; novel; novel coronavirus; opioid use; patient engagement; polygenic risk score; population health; pragmatic trial; programs; response; success; translational genomics; web platform; working group

Project Summary This proposal is in response to a Notice of Special Interest (NOSI) entitled “Urgent Competitive Revisions for Research on Critical Threats to Public Health in Large-Scale Population Cohorts” (NOT-HG-21-020) to focus on NHGRI’s interest in supporting research on pressing public health questions that can uniquely be addressed by collaborative efforts of large international cohort studies. Specifically, we propose to coordinate efforts focused on the collection and analysis of data or samples from ancestrally diverse cohorts of individuals participating in the International HundredK+ Cohort Consortium (IHCC). This proposal will concentrate on the engagement of cohorts from limited resource settings/low- and middle-income countries (LRS/LMICs). The IHCC is supported by the administrative secretariat of the Global Genomic Medicine Collaborative (G2MC), a not-for-profit organization established with the goal of bringing together the global community to enable the implementation of genomic medicine to improve individual and population health. A major goal of the G2MC is to engage the global genomic medicine research community in robust scientific exchange of ideas to advance genomic medicine to clinical practice. We propose to enlist the experience and organizational expertise of the Implementing GeNomics In pracTicE Pragmatic Trials Network (IGNITE PTN) Coordinating Center (CC) at Duke University to work with the G2MC as partners with aligned goals. The IHCC is a community consisting of 103 participating cohorts located in 43 countries, with total current sample sizes across all cohorts of > 50 million participants. This proposal aims to utilize the IGNITE PTN and G2MC secretariat expertise to: 1) expand seven recently awarded IHCC projects to LRS/LMIC cohorts so as to increase ancestral and geographical diversity of the projects as well as the standardization of data capture from the cohorts using resources of the IGNITE PTN, IHCC, and NIH (e.g. PhenX Toolkit); 2) improve inclusivity of LRS/LMIC cohorts using surveys and interviews of LRS/LMIC cohort leadership to determine the gaps and identify solutions required to enhance their effectiveness as IHCC members and as research sites; and 3) plan and pilot the development of a new educational platform and establish an “Education Working Group” to engage, inform and mentor faculty and trainees (the “cohort leaders of tomorrow”) from LRS/LMICs who may wish to build novel cohorts or enhance existing ones. Our track record of collaborative genomic medicine research, program management, and nationally recognized expertise in coordinating large networks uniquely positions us to facilitate the IHCCs strategic goals for cross-cohort communications, scientific program development, capacity building through education and knowledge dissemination, and a robust and interactive web platform.

项目摘要 本建议书是对一份题为“以下方面的紧急竞争修订”的特别关注通知（NOSI）的回应。 大规模人口队列中对公共卫生的重大威胁研究”（NOT-HG-21-020） 关于NHGRI对支持紧迫的公共卫生问题研究的兴趣，这些问题可以独特地 通过大型国际队列研究的合作努力解决。具体而言，我们建议协调 努力的重点是收集和分析来自不同祖先群体的数据或样本 国际百K+队列联盟（International HundredK+ Cohort Consortium，IHCC）本提案将集中于 来自资源有限的国家/中低收入国家（LRS/LMIC）的队列参与。的 IHCC由全球基因组医学合作组织（G2 MC）的行政秘书处提供支持， 一个非营利组织，成立的目标是汇集全球社会， 实施基因组医学以改善个人和人口健康。G2 MC的主要目标是 让全球基因组医学研究界参与强有力的科学思想交流， 基因组医学应用于临床实践。我们建议利用联合国的经验和组织专门知识， 在实践中实施GeNomics实用试验网络（IGNITE PTN）协调中心（CC）， 杜克大学与G2 MC合作，作为目标一致的合作伙伴。IHCC是一个社区， 43个国家的103个参与队列，所有队列的当前总样本量> 50 百万参与者本提案旨在利用IGNITE PTN和G2 MC秘书处的专门知识：1） 将最近授予的七个IHCC项目扩大到LRS/LMIC群体，以增加祖先和 项目的地理多样性以及从同期组群收集数据的标准化， IGNITE PTN、IHCC和NIH的资源（例如PhenX工具包）; 2）提高LRS/LMIC队列的包容性 通过对LRS/LMIC队列领导的调查和访谈，确定差距并确定解决方案 需要提高其作为IHCC成员和研究中心的有效性;以及3）计划和试点 开发一个新的教育平台，并成立一个“教育工作组”， 指导教师和学员（“未来的队列领导者”）从LRS/LMIC谁可能希望建立新的 或加强现有的。我们的合作基因组医学研究，计划的跟踪记录 管理，以及全国公认的协调大型网络的专业知识，使我们能够 促进IHCC的战略目标，以实现跨队列交流、科学计划开发、能力建设、 通过教育和知识传播以及一个强大的互动网络平台进行建设。