The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination

项目摘要 这项提议是对一份题为《紧急竞争修订》的特别利益通知的回应 大规模人群队列公共卫生重大威胁研究(NOT-HG-21-020)聚焦 关于NHGRI对支持关于紧迫的公共卫生问题的研究的兴趣，这些问题可以是独特的 通过大型国际队列研究的合作努力来解决。具体来说，我们建议协调 工作的重点是收集和分析来自不同祖先的个人群体的数据或样本 参加国际HundredK+队列联盟(IHC)。这项提案将集中于 来自有限资源环境/低收入和中等收入国家(LRS/LMIC)的队列参与。这个 IHC由全球基因组医学合作组织(G2MC)行政秘书处提供支持，该组织 非营利组织成立的目标是将全球社区聚集在一起，使 实施基因组医学，改善个人和人群健康。G2MC的一个主要目标是 让全球基因组医学研究界参与强有力的科学交流，以推动 基因组医学走向临床实践。我们建议征集以下机构的经验和组织专长： 在实践中实施基因组学实用试验网络(IGNITE PTN)协调中心(CC)，网址： 杜克大学作为目标一致的合作伙伴与G2MC合作。国际协调委员会是一个由以下成员组成的社区 分布在43个国家和地区的103个参与队列，目前所有队列的总样本量为50 百万参与者。本提案旨在利用IGNITE PTN和G2MC秘书处的专门知识：1) 将最近授予的7个IHC项目扩大到LRS/LMIC队列，以增加祖传和 项目的地域多样性以及从队列中获取数据的标准化 IGNITE PTN、IHCC和NIH的资源(例如PhenX工具包)；2)提高LRS/LMIC队列的包容性 使用对LRS/LMIC队列领导层的调查和访谈来确定差距并确定解决方案 需要加强其作为国际协委会成员和研究地点的有效性；以及3)规划和试行 开发一个新的教育平台，并设立一个“教育工作组”，以参与、通报和 来自LRS/LMIC的导师教职员工和实习生(“未来的队列领导者”)，他们可能希望创建新的 编队或加强现有的。我们在合作基因组医学研究、计划方面的记录 管理，以及全国公认的协调大型网络的专业知识，使我们能够 促进跨队列通信、科学方案开发、能力的国际初级保健中心的战略目标 通过教育和知识传播建设，以及一个强大和互动的网络平台。

Project Summary This proposal is in response to a Notice of Special Interest (NOSI) entitled “Urgent Competitive Revisions for Research on Critical Threats to Public Health in Large-Scale Population Cohorts” (NOT-HG-21-020) to focus on NHGRI’s interest in supporting research on pressing public health questions that can uniquely be addressed by collaborative efforts of large international cohort studies. Specifically, we propose to coordinate efforts focused on the collection and analysis of data or samples from ancestrally diverse cohorts of individuals participating in the International HundredK+ Cohort Consortium (IHCC). This proposal will concentrate on the engagement of cohorts from limited resource settings/low- and middle-income countries (LRS/LMICs). The IHCC is supported by the administrative secretariat of the Global Genomic Medicine Collaborative (G2MC), a not-for-profit organization established with the goal of bringing together the global community to enable the implementation of genomic medicine to improve individual and population health. A major goal of the G2MC is to engage the global genomic medicine research community in robust scientific exchange of ideas to advance genomic medicine to clinical practice. We propose to enlist the experience and organizational expertise of the Implementing GeNomics In pracTicE Pragmatic Trials Network (IGNITE PTN) Coordinating Center (CC) at Duke University to work with the G2MC as partners with aligned goals. The IHCC is a community consisting of 103 participating cohorts located in 43 countries, with total current sample sizes across all cohorts of > 50 million participants. This proposal aims to utilize the IGNITE PTN and G2MC secretariat expertise to: 1) expand seven recently awarded IHCC projects to LRS/LMIC cohorts so as to increase ancestral and geographical diversity of the projects as well as the standardization of data capture from the cohorts using resources of the IGNITE PTN, IHCC, and NIH (e.g. PhenX Toolkit); 2) improve inclusivity of LRS/LMIC cohorts using surveys and interviews of LRS/LMIC cohort leadership to determine the gaps and identify solutions required to enhance their effectiveness as IHCC members and as research sites; and 3) plan and pilot the development of a new educational platform and establish an “Education Working Group” to engage, inform and mentor faculty and trainees (the “cohort leaders of tomorrow”) from LRS/LMICs who may wish to build novel cohorts or enhance existing ones. Our track record of collaborative genomic medicine research, program management, and nationally recognized expertise in coordinating large networks uniquely positions us to facilitate the IHCCs strategic goals for cross-cohort communications, scientific program development, capacity building through education and knowledge dissemination, and a robust and interactive web platform.