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SPIRRIT-HFPEF - DCC

SPIRRIT-HFPEF - DCC
SPIRRIT-HFPEF - DCC
批准号：
10188597
负责人：
Hrishikesh Chakraborty
金额：
$22.17万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-09-15 至 2024-05-31
来源：
https://reporter.nih.gov/project-details/10188597
关键词：
AdultAffectAldosterone AntagonistsCardiovascular systemCase Report FormCause of DeathCessation of lifeClinicalClinical ResearchClinical TrialsClinical Trials Data Monitoring CommitteesClinical effectivenessCommunitiesCommunity PracticeComplexDataData Coordinating CenterData ElementData SetDevelopmentEFRACElectronic Health RecordElementsEnrollmentFosteringGoalsHealth Care CostsHealthcareHeart ArrestHeart failureHospitalizationInterventionIntervention TrialInvestigationLeadershipLeft Ventricular Ejection FractionLifeMichiganMineralocorticoid ReceptorMorbidity - disease rateNational Heart, Lung, and Blood InstituteNorth AmericaOutcomePatient RecruitmentsPatientsPharmaceutical PreparationsPlacebosPrevalencePublic HealthRandomizedRandomized Clinical TrialsRandomized Controlled TrialsRegistriesResearch InstituteResearch PersonnelScheduleSouth AmericaSpecific qualifier valueSpironolactoneStatistical Data InterpretationStructureSwedenTelephoneTestingTherapeuticTherapeutic InterventionTimeUnited StatesUniversitiesUniversity Hospitalsaging populationbaseclinical research siteclinically relevantcompliance behaviorcostdata managementdata qualitydesigneffective therapyevidence baseexperiencefollow-upheart functionheart preservationhospital readmissionimprovedmortalitynovelopen labelpatient populationpragmatic trialpreservationprimary endpointprimary outcomeprospectiverandomized trialsecondary endpointsecondary outcomestandard of caresymptomatic improvementtherapeutically effectivetooltreatment as usual

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中文摘要
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英文摘要
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF) is a pragmatic, registry-based randomized clinical trial that proposes to evaluate the clinical effectiveness of spironolactone versus usual care. The primary hypothesis of SPIRRIT- HFpEF is that treatment with spironolactone will reduce cardiovascular mortality compared with usual care.
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