The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination

项目摘要 请求提供这一行政补编，以支持INIGITE务实审判网络的需要 协调中心(IGNITE PTN CC，U01 HG010225)，以协助国际HundredK队列 在全球基因组医学合作组织(G2MC)的行政支持下， 重点关注NHGRI对研究紧迫的公共卫生问题的兴趣，这些问题可以通过以下方式独特地解决 大型国际队列研究的合作努力。IGNITE PTN CC将使 通过以下目标：目标1：提供协调、后勤和流程资源 G2MC秘书处将a)支持成功完成#年启动的跨群组全球科学项目 2019-2021年，b)为国际协调委员会领导小组提供持续的业务支持，c)准备和支持 全球虚拟和面对面会议议程及其后勤，d)继续建立健全和互动的 (E)完成并启动其五年战略计划。目标2：制定和实施 国际协调委员会的信息技术战略，以便能够确定参加交叉研究的队列 联合科学项目(即联合“发现”)，分享专门知识和科学发现，并发展 国际肝细胞癌社区。这一目标将通过以下方式实现：a)支持ICC全球群组数据地图集 发展，b)举办国际协调委员会讲习班和定期研讨会，c)开展网络活动和外联活动，以 杜克大学和更广泛的科学界。通过实现这些目标，G2MC秘书处将 增加祖先和地理上不同群体在最近获奖项目中的代表性 通过在低资源环境(LR)和低资源环境(LR)中丰富与队列的参与，ICC领导团队 建立一个具有凝聚力和互动性的群体共同体。本副刊 还将通过扩大ICC全球项目来确定参与交叉队列项目的队列 队列数据地图集。Atlas使用联合数据发现模型并协调队列级别的元数据 通过搜索和发现相关人类数据的门户。跨组织倡议将制定和实施 与我们的专业组织网络传播共享的标准和最佳实践， 特派团[例如，全球基因组学与健康联盟(GA4GH)和国际共同疾病 联盟(ICDA)]，从而优化我们的投资。制定一系列有计划的教育论坛，向善 科学交流思想和经验教训将加强知识传播，超越火种 PTN和IHCC。向更广泛的科学界传播共享知识和交流 将通过基于网络的战略和社交媒体渠道来实现。总而言之，我们将促进 队列之间的互动，以创建翻译研究的全球平台，向 疾病的社会、生物和遗传基础，以改善临床护理和人口健康。

Project Summary This administrative supplement is requested to support the needs for the IGNITE Pragmatic Trial Network Coordinating Center (IGNITE PTN CC, U01 HG010225) to assist the International HundredK+ Cohorts Consortium (IHCC), administratively supported by the Global Genomic Medicine Collaborative (G2MC), to focus on NHGRI’s interest in research on pressing public health questions that can uniquely be addressed by collaborative efforts of large international cohort studies. The IGNITE PTN CC will enable advancement of the IHCC through the following aims: Aim 1: To provide coordination, logistical, and process resources for the G2MC secretariat to a) support the successful completion of cross-cohort global scientific projects initiated in 2019-2021, b) provide ongoing operational support for the IHCC leadership teams, c) prepare and support global virtual and face to face meeting agendas and their logistics, d) continue to build a robust and interactive cohorts’ community, and e) complete and launch its 5-year strategic plan. Aim 2: To develop and implement information technology strategies for the IHCC to enable identification of cohorts for participation in cross- cohort scientific projects (i.e., cohort ‘discovery’), the sharing of expertise and scientific findings, and to grow the IHCC community. This aim will be accomplished through a) support of the IHCC Global Cohorts Data Atlas development, b) development of IHCC workshops and regular seminars, and c) web presence and outreach to the Duke University and broader scientific community. By accomplishing these aims, the G2MC secretariat will increase representation of ancestrally and geographically diverse cohorts in recently awarded projects and IHCC leadership teams by enriching involvement with cohorts in low resource settings (LRS) and low- and middle- income countries (LMICs) and building a cohesive and interactive cohorts community. This supplement will also identify cohorts for participation in cross-cohort projects through expansion of the IHCC Global Cohorts Data Atlas. The Atlas utilizes a federated data discovery model and harmonizes cohort level metadata via a portal for search and discovery of relevant human data. Cross-organizational initiatives will develop and disseminate shared standards and best practices with our network of professional organizations with similar missions [e.g., the Global Alliance for Genomics and Health (GA4GH) and the International Common Disease Alliance (ICDA)] thus optimizing our investments. Developing a planned series of educational forums for good scientific exchange of ideas and lessons learned will strengthen knowledge dissemination beyond the IGNITE PTN and IHCC. Dissemination of shared knowledge and communications to the broader scientific community will be accomplished through web-based strategies and social media channels. In summary, we will facilitate interactions between and among cohorts to create a global platform for translational research, informing the social, biological and genetic basis for disease to improve clinical care and population health.