The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination

项目摘要 本行政补充文件旨在支持IGNITE务实审判网络的需要 协调中心（IGNITE PTN CC，U 01 HG 010225）协助国际百K+队列 由全球基因组医学合作组织（G2 MC）提供行政支持的IHCC联盟， 专注于NHGRI对紧迫的公共卫生问题的研究兴趣，这些问题可以通过以下方式来解决： 大型国际队列研究的合作努力。IGNITE PTN CC将推动 IHCC通过以下目标实现：目标1：提供协调、后勤和流程资源， （a）支持成功完成2005年启动的跨群组全球科学项目; 2019-2021年，B）为IHCC领导团队提供持续的运营支持，c）准备和支持 全球虚拟和面对面的会议议程及其后勤，d）继续建立一个强大的和互动的 （e）完成并启动其五年战略计划。目标2：制定和实施 IHCC的信息技术战略，以便能够确定参与交叉 群组科学项目（即，群体“发现”），分享专业知识和科学发现， IHCC社区这一目标将通过以下方式实现：a）支持IHCC全球队列数据图集 B）发展IHCC讲习班和定期研讨会，以及c）网络存在和外联， 杜克大学和更广泛的科学界。通过实现这些目标，G2 MC秘书处将 在最近获得资助的项目中，增加祖先和地理位置不同的群体的代表性， IHCC领导团队通过丰富低资源环境（LRS）和低收入群体的参与， 中等收入国家（LMICs）和建立一个有凝聚力和互动的同龄人社区。这种补充剂 还将通过扩大IHCC全球项目，确定参与跨队列项目的队列 队列数据图集。该图集采用联合数据发现模式，并统一群组一级的元数据 通过门户搜索和发现相关的人类数据。将制定跨组织举措， 与我们的专业组织网络传播共享标准和最佳实践， 任务[例如，全球基因组学与健康联盟（GA 4GH）和国际常见病 联盟（ICDA）]，从而优化我们的投资。制定一系列有计划的教育论坛， 科学交流思想和经验教训将加强IGNITE以外的知识传播 PTN和IHCC。向更广泛的科学界传播共享知识和交流 将通过网络战略和社交媒体渠道完成。总之，我们将促进 群体之间的互动，以创建一个全球平台，为转化研究，通知 社会、生物和遗传基础，以改善临床护理和人口健康。

Project Summary This administrative supplement is requested to support the needs for the IGNITE Pragmatic Trial Network Coordinating Center (IGNITE PTN CC, U01 HG010225) to assist the International HundredK+ Cohorts Consortium (IHCC), administratively supported by the Global Genomic Medicine Collaborative (G2MC), to focus on NHGRI’s interest in research on pressing public health questions that can uniquely be addressed by collaborative efforts of large international cohort studies. The IGNITE PTN CC will enable advancement of the IHCC through the following aims: Aim 1: To provide coordination, logistical, and process resources for the G2MC secretariat to a) support the successful completion of cross-cohort global scientific projects initiated in 2019-2021, b) provide ongoing operational support for the IHCC leadership teams, c) prepare and support global virtual and face to face meeting agendas and their logistics, d) continue to build a robust and interactive cohorts’ community, and e) complete and launch its 5-year strategic plan. Aim 2: To develop and implement information technology strategies for the IHCC to enable identification of cohorts for participation in cross- cohort scientific projects (i.e., cohort ‘discovery’), the sharing of expertise and scientific findings, and to grow the IHCC community. This aim will be accomplished through a) support of the IHCC Global Cohorts Data Atlas development, b) development of IHCC workshops and regular seminars, and c) web presence and outreach to the Duke University and broader scientific community. By accomplishing these aims, the G2MC secretariat will increase representation of ancestrally and geographically diverse cohorts in recently awarded projects and IHCC leadership teams by enriching involvement with cohorts in low resource settings (LRS) and low- and middle- income countries (LMICs) and building a cohesive and interactive cohorts community. This supplement will also identify cohorts for participation in cross-cohort projects through expansion of the IHCC Global Cohorts Data Atlas. The Atlas utilizes a federated data discovery model and harmonizes cohort level metadata via a portal for search and discovery of relevant human data. Cross-organizational initiatives will develop and disseminate shared standards and best practices with our network of professional organizations with similar missions [e.g., the Global Alliance for Genomics and Health (GA4GH) and the International Common Disease Alliance (ICDA)] thus optimizing our investments. Developing a planned series of educational forums for good scientific exchange of ideas and lessons learned will strengthen knowledge dissemination beyond the IGNITE PTN and IHCC. Dissemination of shared knowledge and communications to the broader scientific community will be accomplished through web-based strategies and social media channels. In summary, we will facilitate interactions between and among cohorts to create a global platform for translational research, informing the social, biological and genetic basis for disease to improve clinical care and population health.