Imaging neurovascular physiology in persistent fatigue after COVID-19

项目摘要 在新冠肺炎的初始阶段之后，相当大一部分患者留给了长期的 他们在几个月后继续报告的认知症状，有时被称为“长途”患者。 这些长期的认知障碍即使在只有轻微初始疾病的患者中也可能发生。最多的 常见的症状是持续性疲劳，严重损害日常功能和生活质量。 虽然一部分患者的疲劳是由持续性的心血管或肺损伤来解释的，但许多患者 没有系统性问题出现严重的疲劳，这表明这是一种神经源性疾病。然而，大脑的神经基础 新冠肺炎后的疲劳尚不清楚。到目前为止，有数以百万计的新冠肺炎案例，数十万 人们预计会遭受持续性疲劳的痛苦，并确定潜在的神经生理因素 COVID后的疲劳对于了解这种情况和识别潜在的疾病是至关重要的 治疗路线。鉴于这些症状的患病率和对日常功能的主要影响，这些长期的 我们的目的是研究冠状病毒感染后疲劳的神经基础。我们将使用高空间分辨率 7T功能磁共振检查新冠肺炎后持续性疲劳患者的神经血管功能 颠覆。我们将检查是否发生空间弥漫性神经血管损伤或局灶性破坏。 特定于皮质下觉醒调节回路。该项目将提供一个独特的，高分辨率，和 持续性疲劳患者神经血管生理学的综合评估 新冠肺炎。

Project Abstract After the initial stages of COVID-19, a substantial proportion of patients are left with long-lasting cognitive symptoms that they continue to report months later, sometimes referred to as ‘long-haul’ patients. These long-lasting cognitive disruptions can occur even in patients with only moderate initial illness. The most commonly reported symptom is persistent fatigue, which significantly impairs daily function and quality of life. While fatigue in a subset of patients is explained by lasting cardiovascular or lung damage, many patients with no systemic issues present severe fatigue, suggesting an illness of neural origin. However, the neural basis of post-COVID fatigue is not yet known. With millions of COVID-19 cases to date, hundreds of thousands of people are expected to suffer from persistent fatigue, and identifying the neurophysiological factors underlying post-COVID fatigue is critical in order to develop an understanding of this condition and identify potential treatment routes. Given the prevalence and major impact of these symptoms on daily function in these long- haul patients, we aim to investigate the neural basis of post-COVID fatigue. We will use high spatial resolution 7T fMRI to test whether patients with persistent fatigue after COVID-19 exhibit neurovascular functional disruption. We will examine both whether spatially diffuse neurovascular impairment occurs, or focal disruption specific to subcortical arousal regulatory circuits. This project will provide a unique, high-resolution, and comprehensive assessment of neurovascular physiology in patients experiencing persistent fatigue after COVID-19.