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Project 4: Linking neural, hemodynamic, and multiscale cerebrospinal fluid flow measures in humans

项目 4：将人体神经、血流动力学和多尺度脑脊液流量测量联系起来

基本信息

批准号：
10673167
负责人：
Laura Diane Lewis
金额：
$ 52.94万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673167
关键词：
Acetylcholine Anterior Arousal Automobile Driving Behavioral Blood Vessels Brain Brain imaging Cell Nucleus Cerebrospinal Fluid Collaborations Common Data Element Coupled Electroencephalography Electrophysiology (science)Frequencies Functional Magnetic Resonance Imaging Goals Human Image Imaging Techniques Link Liquid substance Magnetic Resonance Imaging Maps Measurement Measures Modeling Multimodal Imaging Mus Neuromodulator Neurons Norepinephrine Pattern Play Property Resolution Role Sensory Shapes Signal Transduction Sleep Sleep Stages Specific qualifier value Stimulus Subarachnoid Space Techniques Technology Testing Theoretical model Translating Travel Update Visual Wakefulness basal forebrain brain shape cerebrospinal fluid flow fluid flow hemodynamics locus ceruleus structure neural neural circuit neural patterning neuromechanism neuroregulation neurovascular coupling non rapid eye movement novel predictive modeling response solute spatiotemporal visual stimulus

项目摘要

Abstract, Project 4 During NREM sleep, large waves of cerebrospinal fluid (CSF) flow appear in the brain. Neural slow waves precede these CSF flow waves by several seconds, suggesting that coherent neural activity could drive CSF flow by inducing large-scale neurovascular coupling. This project will test the hypothesis that the spatiotemporal dynamics of neural activity regulate how CSF flows in the human brain. We will optimize and integrate multiple novel MR technologies to image CSF flow in the ventricles and in perivascular spaces, with simultaneous measures of neural activity using EEG, and hemodynamic responses using fMRI. In Aim 1, we will test whether spatiotemporally patterned neural activity is linked to CSF flow, measured during well-established visual tasks. In Aim 2, we will test whether the dynamics of spontaneous neural activity during sleep are coupled to CSF flow at multiple spatial scales. In Aim 3, we will identify how activity in basal forebrain and locus coeruleus, which release norepinephrine and acetylcholine, is linked to the relationship between coherent neural activity and CSF flow. Together, these Aims will test how neural activity is linked to CSF flow across sleep and wakefulness in the human brain, from ventricles down to perivascular spaces. Project 4 will contribute to the overall U19 goals by determining the link between neural activity and CSF flow at multiple spatial scales. By performing whole-brain imaging in humans, we can test how both local and global neural dynamics are linked to CSF flow in the tiny perivascular spaces and in the much-larger ventricles. By interacting with Project 2, our EEG-based measures of neural coherence will be linked to cellular-level measures of neuronal activity, with both our projects testing the link to CSF flow in the perivascular space. Our interactions with Project 3 will be critical to inform how neuromodulators shape vascular dynamics, and how neurovascular coupling is altered across sleep and wakefulness. Finally, our continuous interactions with Project 1 will be essential in order to determine which empirical measurements are needed to fully specify the model, and then update the model to make further predictions.

项目4摘要