Imaging neural dynamics at high temporal resolution in sleep and sleep deprivation

以高时间分辨率对睡眠和睡眠剥夺中的神经动力学进行成像

• 批准号: 9415411
• 负责人: Laura Diane Lewis
• 金额: $ 13.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-23 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9415411
• 关键词: Affect; Anatomy; Anesthesia procedures; Animals; Arousal; Arousal and Regulatory Systems; Attention; Autistic Disorder; Behavior; Behavioral; Biological Markers; Bipolar Disorder; Brain; Brain Stem; Brain imaging; Characteristics; Clinical; Cognition; Cognitive deficits; Complex; Data; Detection; Development; Diagnosis; Disease; Educational Status; Electroencephalography; Electrophysiology (science); Ensure; Exhibits; Exposure to; Failure; Foundations; Frequencies; Functional Magnetic Resonance Imaging; General Population; Human; Image; Image Analysis; Imaging Techniques; Impaired cognition; Individual; Lead; Light; Link; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mental Depression; Mental disorders; Mentors; Mentorship; Methodology; Methods; Modeling; Neurobehavioral Manifestations; Neurosciences; Onset of illness; Patients; Pattern; Performance; Pharmacologic Substance; Pharmacology; Play; Positioning Attribute; Property; Recovery; Regulation; Research; Rest; Role; Schizophrenia; Sensory; Signal Transduction; Sleep; Sleep Deprivation; Slice; Spatial Distribution; Structure; Symptoms; System; Techniques; Testing; Thalamic Nuclei; Thalamic structure; Training; Variant; Work; association cortex; awake; blood oxygenation level dependent response; cognitive function; collaborative environment; density; hemodynamics; imaging approach; imaging modality; imaging study; improved; innovation; neural circuit; neuroimaging; neurophysiology; novel; programs; psychiatric symptom; relating to nervous system; response; sensory cortex; sensory stimulus; signal processing; sleep abnormalities; sleep regulation; sustained attention; temporal measurement; transmission process

Project Abstract Many psychiatric disorders including schizophrenia, depression, and autism, are associated with disrupted sleep. Disrupted sleep may contribute to negative cognitive symptoms, as sleep is crucial for maintaining and restoring healthy brain function. In particular, the slow (0.1-1 Hz) oscillations characteristic of deep sleep are thought to play essential roles in the restorative functions of sleep, and these oscillations have complex spatial properties that may be important for their effects on cognition. However, determining how slow oscillations influence brain function has been challenging due to our current inability to measure slow oscillations with spatial precision throughout the whole brain. This project exploits the recent development of accelerated multi-slice imaging methods to measure fast (>0.2 Hz) fMRI signals. This work is centered around an innovative use of accelerated fMRI with simultaneous EEG to directly measure slow oscillation dynamics throughout the human brain simultaneously, and use this information to create the first whole-brain maps of slow oscillations. We will first optimize imaging and analysis methods for localizing slow oscillations. We will then test a hypothesis for how slow oscillations affect cognitive function: namely, that spatially localized slow oscillations in cortex and thalamus lead to reorganized information transfer across cortical networks, and thereby influence cognitive function. The candidate has expertise in systems neuroscience of arousal regulation, anesthesia pharmacology, electrophysiology, and signal processing, providing a strong foundation for conducting this advanced imaging study of sleep states. The K99 will provide necessary training in 1) functional and anatomical MRI; 2) simultaneous EEG-fMRI during sleep; and 3) human sleep neurophysiology. The research will take place at the Athinoula A. Martinos Center, a highly collaborative environment equipped with state-of-the-art facilities for neuroimaging. The primary mentor Prof. Bruce Rosen will provide mentorship in neuroimaging and in transitioning to an independent position. In addition, the co-mentor Prof. Robert Stickgold will provide training in sleep neurophysiology, as well as exposure to clinical contexts of how sleep is affected in psychiatric disorders, and how disrupted sleep can contribute to cognitive deficits. Additional advice from Dr. Jonathan Polimeni and Dr. Jeff Duyn on imaging and analysis techniques will ensure high-level training in these methodological approaches. This methodological and scientific training will enable the candidate both to successfully complete these aims and to develop an independent research program focused on the systems neuroscience of sleep and arousal regulation, how sleep circuits and sleep-modulating pharmaceutical agents influence cortical function, and how sleep deficits lead to disrupted cognition. The results of this research will contribute to improved methods for imaging dynamics in the human brain, and shed light on the effects of sleep deprivation, which have significant negative effects both on the general population and particularly in patients with psychiatric disorders.

项目摘要 许多精神疾病，包括精神分裂症，抑郁症和自闭症，都与 扰乱睡眠。睡眠中断可能会导致负面的认知症状，因为睡眠对 保持和恢复健康的大脑功能。特别是，缓慢（0.1-1赫兹）振荡的特点， 深度睡眠被认为在睡眠的恢复功能中起着重要作用，这些振荡 复杂的空间特性，可能对认知的影响很重要。然而，确定有多慢 由于我们目前无法测量缓慢的振荡， 在整个大脑中进行精确的空间振荡。 该项目利用最新发展的加速多切片成像方法来测量 快速（>0.2 Hz）fMRI信号。这项工作是围绕一个创新的使用加速功能磁共振成像与 同步EEG以同时直接测量整个人脑的缓慢振荡动力学， 并利用这些信息来创建第一个慢振荡的全脑地图。我们将首先优化成像 以及用于局部化慢振荡的分析方法。然后，我们将测试一个假设， 影响认知功能：即，皮质和丘脑中的空间局部缓慢振荡导致 重新组织信息在皮层网络中的传递，从而影响认知功能。 候选人具有唤醒调节系统神经科学，麻醉药理学， 电生理学和信号处理，为进行这种先进的成像提供了坚实的基础 睡眠状态的研究。K99将提供以下方面的必要培训：1）功能和解剖MRI; 2） 睡眠期间同步EEG-fMRI;和3）人类睡眠神经生理学。这项研究将在 阿提努拉湖Martinos中心，一个高度协作的环境，配备了最先进的设施， 神经成像主要导师布鲁斯罗森教授将提供神经成像和 过渡到独立的位置。此外，共同导师教授罗伯特Stickgold将提供培训， 睡眠神经生理学，以及暴露于睡眠如何在精神病患者中受到影响的临床背景， 以及睡眠中断如何导致认知缺陷。乔纳森博士的补充建议 Polimeni和Jeff Duyn博士的成像和分析技术将确保这些方面的高水平培训 方法论。这种方法和科学的培训将使候选人既 成功地完成这些目标，并制定一个独立的研究计划，重点放在系统 睡眠和觉醒调节的神经科学，睡眠回路和睡眠调节药剂 影响皮层功能，以及睡眠不足如何导致认知中断。这项研究的结果将 有助于改善人类大脑中成像动态的方法，并阐明睡眠的影响 剥夺，这对一般人群，特别是病人有重大的负面影响 患有精神疾病