Inflammasome-based Alzheimer's disease therapy in the context of diabetes

糖尿病背景下基于炎症小体的阿尔茨海默病治疗

基本信息

  • 批准号:
    10287353
  • 负责人:
  • 金额:
    $ 40.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Scope of Work / Abstract This Administrative Supplement proposal is to investigate the role of inflammasome signaling in models of Alzheimer's disease (AD) complicated by diabetes mellitus (DM). AD is a progressive neurodegeneration accounting for 60-70% of all the dementia worldwide. DM, the metabolic syndrome responsible for a variety of complications including diabetic retinopathy (the subject of the parent proposal), is characterized by hyperglycemia, hyperinsulinemia, and insulin resistance. Numerous epidemiologic analyses have identified DM as a significant risk factor and comorbidity for AD. In addition, DM and AD share inflammasome activation as pathomechanisms, and each entity has independently been shown to be responsive to inflammasome inhibition. We propose to test the overall hypothesis that inflammasome inhibition reduces neuroinflammation and improves cognitive outcomes in mouse AD models that are complicated by the co-morbidity of DM. To accomplish this, we will critically assess the spatial and temporal kinetics of inflammasome activation in the brain in combined DM/AD models. In addition, we will test whether the presence of DM affects the efficacy of inflammasome inhibition on cognitive outcomes of AD mouse models. As such, this supplement request focused on AD is within the scope of the active parent NIH award and has the potential to stimulate new studies for examining novel molecular and biochemical mechanisms of inflammasome activation in AD in the presence of metabolic disorders. We predict that establishing inflammasome as a key link between DM and AD will stimulate additional activity on the part of endocrinologists, immunologists, and neurobiologists thereby leading to progress in deciphering and potentially treating AD and related dementias complicated by DM. This supplement will also enable our laboratory to develop a focus on AD and related dementias by generating additional experimental data that can be leveraged to submit new proposals focused directly on AD and related dementias.
工作范围/摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jayakrishna Ambati其他文献

Jayakrishna Ambati的其他文献

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{{ truncateString('Jayakrishna Ambati', 18)}}的其他基金

Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina
衰老视网膜中的胞质 SINE 逆转录转座元件 cDNA 和线粒体 DNA
  • 批准号:
    10722062
  • 财政年份:
    2023
  • 资助金额:
    $ 40.37万
  • 项目类别:
Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's disease
定义 SINE 逆转录转座子和炎症小体激活在阿尔茨海默病中的作用
  • 批准号:
    10696066
  • 财政年份:
    2022
  • 资助金额:
    $ 40.37万
  • 项目类别:
Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's disease
定义 SINE 逆转录转座子和炎症小体激活在阿尔茨海默病中的作用
  • 批准号:
    10517678
  • 财政年份:
    2022
  • 资助金额:
    $ 40.37万
  • 项目类别:
Nlrp3 inflammasome activation in early diabetic retinopathy - Administrative Supplement ERG Request
早期糖尿病视网膜病变中 Nlrp3 炎症小体激活 - 行政补充 ERG 请求
  • 批准号:
    10643583
  • 财政年份:
    2020
  • 资助金额:
    $ 40.37万
  • 项目类别:
Nlrp3 inflammasome activation in early diabetic retinopathy
早期糖尿病视网膜病变中 Nlrp3 炎性体激活
  • 批准号:
    10414049
  • 财政年份:
    2020
  • 资助金额:
    $ 40.37万
  • 项目类别:
Nlrp3 inflammasome activation in early diabetic retinopathy
早期糖尿病视网膜病变中 Nlrp3 炎性体激活
  • 批准号:
    10626060
  • 财政年份:
    2020
  • 资助金额:
    $ 40.37万
  • 项目类别:
Visual system and cognitive biology in normal animals versus in an animal model of Alzheimer's disease with or without diabetes treated with solo or dual inflammasome inhibitors
正常动物的视觉系统和认知生物学与单独或双重炎性体抑制剂治疗的患有或不患有糖尿病的阿尔茨海默病动物模型的比较
  • 批准号:
    10712956
  • 财政年份:
    2020
  • 资助金额:
    $ 40.37万
  • 项目类别:
Non-canonical inflammasome in activation in RPE degeneration
RPE 变性中激活的非典型炎症小体
  • 批准号:
    10338080
  • 财政年份:
    2019
  • 资助金额:
    $ 40.37万
  • 项目类别:
Antigen-independent suppression of ocular angiogenesis via the Fc receptor
通过 Fc 受体对眼部血管生成进行抗原非依赖性抑制
  • 批准号:
    10003425
  • 财政年份:
    2018
  • 资助金额:
    $ 40.37万
  • 项目类别:
Antigen-independent suppression of ocular angiogenesis via the Fc receptor
通过 Fc 受体对眼部血管生成进行抗原非依赖性抑制
  • 批准号:
    9765313
  • 财政年份:
    2018
  • 资助金额:
    $ 40.37万
  • 项目类别:

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