Data Core RC2

数据核心 RC2

• 批准号: 10294031
• 负责人: Richard H Fortinsky
• 金额: $ 40.55万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294031
• 关键词: African American; Aging; Agreement; American; Basic Science; Behavior; Behavior Therapy; Biological Markers; Biometry; COVID-19; Capsicum; Cells; Clinic; Clinical Trials; Cognition; Cognitive; Collaborations; Computer software; Conduct Clinical Trials; Data; Data Analyses; Data Pooling; Data Security; Data Store; Database Management Systems; Databases; Detection; Development; Devices; Discipline; Elderly; Enrollment; Ensure; Funding; Gait; Generations; Genetic; Genomic medicine; Genomics; Geriatrics; Gerontology; Goals; Growth; Health; Heterogeneity; Host Defense; Impaired cognition; Individual; Intervention; Knowledge; Lead; Learning; Link; Longitudinal Studies; Measurement; Measures; Mediation; Mendelian randomization; Mental Depression; Metformin; Mission; Molecular; Online Systems; Outcome; Participant; Peripheral Blood Mononuclear Cell; Phenotype; Physical Function; Pilot Projects; Population Study; Productivity; Regulation; Reproducibility; Research; Research Design; Research Personnel; Research Support; Resolution; Resources; Science; Scientist; Secure; Services; Source; Techniques; The Jackson Laboratory; United States National Institutes of Health; Vaccines; Work; base; biomarker discovery; biomarker validation; causal model; cohort; data exchange; data resource; data standards; disability; early detection biomarkers; education research; epidemiology study; experience; frailty; genetic epidemiology; geriatric depression; hands-on learning; improved; influenza virus vaccine; innovation; longitudinal analysis; microbiome analysis; microbiome research; next generation sequencing; operation; population based; ranpirnase; recruit; senescence; single-cell RNA sequencing; standardize measure; vaccine trial

PROJECT SUMMARY/ABSTRACT – Data Resource Core (RC2) The overall goal of RC2 is to enhance scientific productivity of investigators and projects supported by the UConn OAIC, and to external project investigators, by providing ready access to knowledge, expertise, and services related to study design, data capture, database management, data analysis, and measurement approaches. RC2 will support research relevant to Precision Gerontology in 4 functional domains, consistent with the theme of the UConn OAIC, and to independence of older persons. RC2 will offer individualized services as well as organized didactic and interactive learning opportunities, and in conjunction with other OAIC components will manage and provide access to a cross-study database with standardized measures for generation of new studies. RC2 will provide data-related support to 3 Pilot Studies in Year 1 as well as 2 Developmental Projects, including an RC2 Developmental Project featuring single cell RNAseq genomic profiling of PBMCs from metformin-flu vaccine biomarker data (in Year 1), and analyses linking biomarker data with physical function and frailty measures from one of the OAIC-supported pilot studies (PESC3; in Year 2).

项目摘要/摘要-数据资源核心(RC2) RC2的总体目标是提高研究人员和项目的科学生产力 由康涅狄格州大学OAIC支持，并通过提供随时可用的访问方式向外部项目调查人员提供支持 与研究设计、数据捕获、数据库相关的知识、专业知识和服务 管理、数据分析和测量方法。RC2将支持相关研究 在4个功能领域的精准老年学，与康涅狄格州大学OAIC的主题一致， 以及老年人的独立。RC2将提供个性化服务以及 组织授课和互动学习机会，并与其他OAIC合作 组件将管理并提供对标准化的交叉研究数据库的访问 产生新研究的措施。RC2将为3项试点研究提供数据相关支持 在第一年以及两个开发项目中，包括RC2开发项目 二甲双胍-流感疫苗生物标志物PBMC的单细胞RNAseq基因组图谱特征 数据(第1年)，以及将生物标记物数据与身体机能和脆弱性指标联系起来的分析 来自伊斯兰会议组织支持的一项试点研究(PESC3；第2年)。