Data Core RC2

项目概要/摘要-数据资源核心（RC 2） RC 2的总体目标是提高研究者和项目的科学生产力 由康州大学OAIC和外部项目调查人员提供支持， 与研究设计、数据采集、数据库相关的知识、专业知识和服务 管理、数据分析和测量方法。RC 2将支持相关研究 在4个功能领域的精密老年学，与康州大学OAIC的主题一致， 以及老年人的独立性。RC 2将提供个性化服务， 组织教学和互动学习机会，并与其他OAIC 组件将管理并提供对交叉研究数据库的访问， 产生新研究的措施。RC 2将为3项试点研究提供数据相关支持 1年级以及2个发展项目，包括RC 2发展项目 以来自二甲双胍-流感疫苗生物标志物的PBMC的单细胞RNAseq基因组谱为特征 数据（第1年），以及将生物标志物数据与身体功能和虚弱指标联系起来的分析 来自OAIC支持的试点研究之一（PESC 3;第2年）。

PROJECT SUMMARY/ABSTRACT – Data Resource Core (RC2) The overall goal of RC2 is to enhance scientific productivity of investigators and projects supported by the UConn OAIC, and to external project investigators, by providing ready access to knowledge, expertise, and services related to study design, data capture, database management, data analysis, and measurement approaches. RC2 will support research relevant to Precision Gerontology in 4 functional domains, consistent with the theme of the UConn OAIC, and to independence of older persons. RC2 will offer individualized services as well as organized didactic and interactive learning opportunities, and in conjunction with other OAIC components will manage and provide access to a cross-study database with standardized measures for generation of new studies. RC2 will provide data-related support to 3 Pilot Studies in Year 1 as well as 2 Developmental Projects, including an RC2 Developmental Project featuring single cell RNAseq genomic profiling of PBMCs from metformin-flu vaccine biomarker data (in Year 1), and analyses linking biomarker data with physical function and frailty measures from one of the OAIC-supported pilot studies (PESC3; in Year 2).