Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional)

Claude D. Pepper 美国老年人独立中心（P30 临床试验可选）

• 批准号: 10668310
• 负责人: Richard H Fortinsky
• 金额: $ 135.02万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668310
• 关键词: ARHGEF5 gene; Address; Affect; Aging; American; Area; Award; Behavior; Behavioral; Biological; Biological Markers; Capsicum; Caring; Clinical; Clinical Investigator; Clinical Trials; Cognition; Communities; Development; Dimensions; Discipline; Disease; Education; Effectiveness of Interventions; Elderly; Environmental Risk Factor; Epidemiologist; Foundations; Funding; Genetic; Genomic medicine; Geriatrics; Gerontology; Geroscience; Goals; Growth; Health; Heterogeneity; Home; Host Defense; Individual; Institution; Intervention; Knowledge; Leadership; Learning; Life; Mission; Outcome; Physiological; Pilot Projects; Research; Research Methodology; Research Personnel; Resources; Science; Scientist; Techniques; Testing; The Jackson Laboratory; Time; bench to bedside; career; clinical care; clinical translation; collaborative approach; community engagement; data resource; design; education research; experience; improved; innovation; insight; interdisciplinary approach; multidisciplinary; multiple chronic conditions; next generation; novel; novel strategies; population based; pre-clinical; pre-clinical research; precision medicine; preference; programs; recruit; research study; social; social factors; synergism; tool; treatment response

PROJECT SUMMARY OVERALL This proposal seeks to establish the Claude D Pepper Older Americans Independence Center at UConn (UConn OAIC) with the overarching goal of developing clinical strategies for enhancing function and independence in older adults that are more precise, personalized, and effective. Our focus on Precision Gerontology has emerged through the collective experiences and insights of our multidisciplinary team of accomplished investigators in the UConn Center on Aging – all united by a shared commitment to improving the lives of older adults through research, education, and clinical care. Our emphasis on Precision Gerontology has been guided by three principles: 1. A growing heterogeneity or variability over time among individuals involving all aspects of aging that therefore necessitates a multidisciplinary team-based approach to aging research; 2. Increased heterogeneity or variability with aging in older adults’ responses to treatment, highlighting the need for better targeting; and 3. Recognition of a need to incorporate these considerations into the design and testing of novel geroscience-guided therapies. These objectives will be achieved by establishing a UConn OAIC through the coordinated activities of a Leadership and Administration Core (LAC), Recruitment and Community Engagement Core (RC1), Data Resource Core (RC2), Biomarker and Preclinical Research Core (RC3), Pilot and Exploratory Studies Core (PESC), and Research Education Component (REC). We will seek to address these goals through the following aims: Aim 1: To develop and refine new approaches to the study and clinical translation of Precision Gerontology. Aim 2: To develop and evaluate new research methods, techniques, and collaborative approaches required to advance the goals of Precision Gerontology. Aim 3: To identify, develop, and learn from experiences of the next generation of researchers poised to become leaders in geriatrics research related to the UConn OAIC focus. Aim 4: To select and support innovative pilot studies that show promise in helping to guide the design, funding, and completion of more definitive future research studies related to the UConn OAIC focus.

总体项目总结 该提案寻求建立克劳德·D·佩珀老年美国人独立中心 在康涅狄格州大学(UConn OAIC)，首要目标是开发临床策略 增强老年人的功能和独立性，使其更加精确、个性化和 有效。我们对精准老年学的关注是通过集体经验产生的 以及我们在康涅狄格州康涅狄格州大学中心的多学科研究团队的见解 老龄化-所有人都因共同致力于通过以下方式改善老年人的生活而团结在一起 研究、教育和临床护理。 我们对精准老年学的重视遵循三个原则：1.不断增长 个体间的异质性或随时间的变异性涉及衰老的各个方面 因此，有必要对老龄化研究采取基于多学科团队的方法；2.增加 老年人对治疗反应的异质性或随年龄增长的变异性，突出了 需要更好地确定目标；以及3.认识到有必要将这些考虑纳入 老年科学指导的新型疗法的设计和测试。 这些目标将通过建立康涅狄格州大学OAIC通过协调 领导和行政核心(LAC)、招聘和社区的活动 参与核心(RC1)、数据资源核心(RC2)、生物标记物和临床前研究 核心(RC3)、试点和探索性研究核心(PESC)和研究教育部分 (记录)。 我们将通过以下目标努力实现这些目标： 目标1：开发和改进研究和临床翻译的新方法 老年学。 目标2：开发和评估新的研究方法、技术和协作 推进精准老年学目标所需的方法。 目标3：确定、发展和学习下一代研究人员的经验 准备成为与康涅狄格州大学OAIC焦点相关的老年病学研究的领导者。 目标4：选择和支持创新的试点研究，这些研究在帮助指导 设计、资助和完成更明确的未来研究 康涅狄格州大学OAIC Focus。

项目成果

Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults.

颗粒酶 B：对于接种疫苗的老年人应对流感感染的一把双刃剑。

• DOI: 10.3389/fragi.2021.753767
• 发表时间: 2021
• 期刊: Frontiers in aging
• 作者: Verschoor,ChrisP;Pawelec,Graham;Haynes,Laura;Loeb,Mark;Andrew,MelissaK;Kuchel,GeorgeA;McElhaney,JanetE
• 通讯作者: McElhaney,JanetE

Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes.

疗养院老年人与虚弱相关的人类微生物群失调。

• DOI: 10.1038/s43587-022-00289-7
• 发表时间: 2022
• 期刊: Nature aging
• 作者: Oh,Julia;Robison,Julie;Kuchel,GeorgeA
• 通讯作者: Kuchel,GeorgeA

Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.

• DOI: 10.1016/j.jagp.2022.01.012
• 发表时间: 2022-07
• 期刊: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 7.2
• 作者: Diniz, Breno S.;Lima-Costa, Maria Fernanda;Peixoto, Sergio Viana;Firmo, Joselia O. A.;Torres, Karen C. L.;Martins-Filho, Olindo Assis;Teixeira-Carvalho, Andrea;Grady, James;Kuchel, George A.;Castro-Costa, Erico
• 通讯作者: Castro-Costa, Erico

High Risk of Substance Use Disorder-Related Outcomes in Veterans Released from Correctional Facilities in Mid to Late Life.

从惩教所释放的中晚年退伍军人中，药物使用障碍相关后果的风险很高。

• DOI: 10.1007/s11606-023-08057-y
• 发表时间: 2023
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Barry,LisaC;Steffens,DavidC;Covinsky,KennethE;Conwell,Yeates;Boscardin,John;Li,Yixia;Byers,AmyL
• 通讯作者: Byers,AmyL

Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.

• DOI: 10.1186/s12979-022-00284-x
• 发表时间: 2022-05-26
• 期刊: Immunity & ageing : I & A