THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANT

西奈山伊坎医学院的Tisch癌症研究所 首席调查员/主任：Ramon Parsons，医学博士 摘要：Tisch癌症研究所的使命是促进基础、临床和人群健康的癌症 研究，以预防健康个人的癌症，并改善癌症患者及其家人的生活 在我们不同的社区。为了完成这一使命，TCI开发了合作研究计划 努力将发现转化为新的疗法，并开发新的预防和交付战略 优先考虑影响我们集水区的癌症。TCI的四个癌症研究项目是：癌症 免疫学、癌症机制、癌症预防与控制、癌症临床研究。在ITS内 在四个项目中，TCI拥有雄厚的癌症研究基础，与癌症相关的直接资金 53,106,982美元。这包括同行审查的36,910,750美元，其中27,662,959美元是国立卫生研究院的资金， 其中包括来自NCI的15,939,357美元。TCI通过以下方式促进方案内和方案间的癌症研究 战略规划、试点项目奖励、跨学科会议和务虚会以及针对疾病的重点 组。此外，TCI通过提供出色的核心、设备和设施来支持尖端研究 和信息技术。TCI支持以下五个共享资源：流式细胞术、小鼠遗传学、 显微镜、生物统计学和人类免疫监测中心，以及以下三个核心- 发展：生物仓库和病理学核心，用于下一代测序的生物信息学，以及 生物医学数据科学与信息学。癌症临床试验办公室及其早期新成立 阶段试验单位提供基础设施，以执行由TCI开发的由调查员发起的新方案 调查人员。TCI的集水区包括东哈莱姆的纽约市(NYC)社区， 中央哈莱姆区和上东区，哈莱姆夫妇经历了过高的癌症发病率、发病率和 与纽约市和美国相比的死亡率。此外，TCI还是世界贸易的协调中心 中心第一反应人员计划，与受9·11袭击影响的救援人员形成了鲜明而独特的 TCI集水区的组成部分。TCI发展和培育了一支充满活力的科学家团队，临床 研究人员和管理人员并提供刺激新癌症所需的研究基础设施支持 发现并改善癌症患者及其家人的结局。

TISCH CANCER INSTITUTE AT THE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Principal Investigator/Director: Ramon Parsons, MD, PhD ABSTRACT: The mission of the Tisch Cancer Institute is to advance basic, clinical and population health cancer research, so as to prevent cancer in healthy individuals and improve the lives of cancer patients and their families in our diverse communities. To accomplish this mission, the TCI has developed collaborative research programs that strive to translate discoveries to new therapies and to develop new prevention and delivery strategies with priority given to cancers affecting our catchment area. TCI’s four cancer research programs are: Cancer Immunology, Cancer Mechanisms, Cancer Prevention and Control, and Cancer Clinical Investigation. Within its four programs, the TCI has a strong foundation of cancer research with direct cancer-related funding of $53,106,982. This includes peer-reviewed funding of $36,910,750, of which $27,662,959 is NIH funding, including $15,939,357 from the NCI. The TCI fosters intra and inter-programmatic cancer research through strategic planning, pilot project awards, interdisciplinary meetings and retreats, and disease-specific focus groups. In addition, the TCI enables cutting-edge research by providing outstanding cores, equipment, facilities and information technology. TCI supports the following five shared resources: Flow Cytometry, Mouse Genetics, Microscopy, Biostatistics, and Human Immune Monitoring Center, as well as the following three cores-in- development: Biorepository and Pathology Core, Bioinformatics for Next Generation Sequencing, and Biomedical Data Science and Informatics. The Cancer Clinical Trials Office with its newly established Early Phase Trials Unit provides the infrastructure to conduct novel, investigator initiated protocols developed by TCI investigators. The TCI’s catchment area includes the New York City (NYC) neighborhoods of East Harlem, Central Harlem and the Upper East Side, with the Harlems experiencing excess cancer incidence, morbidity and mortality as compared to NYC and the US. In addition, the TCI is the coordinating center for the World Trade Center First Responders Program, and the rescue workers affected by the 9/11 attacks form a distinct and unique component of the TCI catchment area. TCI develops and fosters a dynamic team of scientists, clinical investigators and administrators and provides the research infrastructure support needed to spur new cancer discoveries and improve the outcomes of cancer patients and their families.