The Tisch Cancer Institute - Cancer Center Support Grant

蒂施癌症研究所 - 癌症中心支持补助金

• 批准号: 9753966
• 负责人: Ramon E Parsons
• 金额: $ 237.3万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753966
• 关键词: Academic Medical Centers; Administrator; Affect; Antigen-Presenting Cells; Award; Basic Science; Biology; Cancer Center Support Grant; Cancer Immunology Science; Cancer Patient; Catchment Area; Cells; Clinical Research; Collaborations; Communities; Cytotoxic T-Lymphocytes; Dendritic Cells; Development; Education and Outreach; Enrollment; Equipment; Family; Genomics; Helper-Inducer T-Lymphocyte; Immune; Immune System Diseases; Immune system; Immunologist; Immunology; Immunotherapy; Information Technology; Infrastructure; Institutes; Journals; Leadership; Malignant Neoplasms; Mediating; Mission; New York; Patients; Peer Review; Physicians; Population; Population Research; Pre-Clinical Model; Prevention; Principal Investigator; Publishing; Quality of life; Reporting; Research; Role; Scientist; T-Lymphocyte; Translating; Translational Research; Tumor Antigens; Tumor Immunity; Work; anti-tumor immune response; anticancer research; cancer care; cancer education; cancer immunotherapy; cancer therapy; clinical care; ethnic diversity; immunogenicity; immunotherapy trials; improved; innovation; macrophage; medical schools; member; novel; pre-clinical; programs; public health relevance; tumor; tumor growth; tumor microenvironment; tumor progression

 DESCRIPTION (provided by applicant): Cancer progression is characterized by gradual dysregulation of the immune system at multiple levels that is considered to directly contribute to unchecked tumor growth. The central theme of the Cancer Immunology (CI) Research Program is to identify mechanisms underlying the suppression of effective anti-tumor immunity that could instruct the development of novel and impactful immunotherapies. Dendritic cells (DCs), potent antigen presenting cells, initiate anti-tumor immune responses, which are subsequently mediated by CD4+ helper cells and cytotoxic T cells. Immunologists have historically focused on characterizing the role of tumor infiltrating T cells (TILs) in restraining tumor growth, but thereis emerging evidence that innate immune cells, such as DC and macrophages, are strongly affected by the tumor micro-environment (TME) and major contributors to tumor progression. The CI Research Program has three main scientific objectives. They are to: 1) Characterize mechanisms underlying DC and macrophage immune dysregulation in the tumor micro-environment; 2) Develop preclinical models to reverse innate immune dysfunction and restore immunogenicity to tumor associated antigens, and 3) Translate preclinical discoveries into cancer immunotherapy trials. The CI program has 21 members, and they represent 10 departments and 3 institutes (The Tisch Cancer Institute, Immunology Institute, Icahn Institute for Genomics and Multiscale Biology). As of July 1, 2014, program members were awarded $4,016,010 in NCI and other peer reviewed cancer-related direct support. Members of the CI Program have been increasingly successful in publishing their research in high impact journals. Since 2011, CI program members published 163 reports, of which 14.7% were intra-programmatic and 23.9% inter-programmatic.

 描述（由申请人提供）：癌症进展的特点是免疫系统在多个水平上逐渐失调，这被认为直接导致不受控制的肿瘤生长。癌症免疫学 (CI) 研究计划的中心主题是确定抑制有效抗肿瘤免疫的机制，以指导开发新型且有效的免疫疗法。树突状细胞 (DC) 是一种有效的抗原呈递细胞，可启动抗肿瘤免疫反应，随后由 CD4+ 辅助细胞和细胞毒性 T 细胞介导。免疫学家历来关注于表征肿瘤浸润 T 细胞 (TIL) 在抑制肿瘤生长中的作用，但新的证据表明，先天免疫细胞，如 DC 和巨噬细胞，受到肿瘤微环境 (TME) 的强烈影响，是肿瘤进展的主要因素。 CI 研究计划有三个主要科学目标。他们的目的是： 1) 表征肿瘤微环境中 DC 和巨噬细胞免疫失调的机制； 2) 开发临床前模型以逆转先天免疫功能障碍并恢复肿瘤相关抗原的免疫原性，以及 3) 将临床前发现转化为癌症免疫治疗试验。 CI 项目有 21 名成员，他们代表 10 个部门和 3 个研究所（蒂施癌症研究所、免疫学研究所、伊坎基因组学和多尺度生物学研究所）。截至 2014 年 7 月 1 日，项目成员获得了 4,016,010 美元的 NCI 和其他经过同行评审的癌症相关直接支持。 CI 项目的成员在高影响力期刊上发表研究成果越来越成功。自2011年以来，CI项目成员发布了163份报告，其中14.7%是项目内报告，23.9%是项目间报告。