Core A: Administrative

核心A：行政

• 批准号: 10295513
• 负责人: ALISON M GOATE
• 金额: $ 16.61万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10295513
• 关键词: 17q21; Advisory Committees; Awareness; Benchmarking; Budgets; Chromosomes; Collaborations; Common Data Element; Communication; Communities; Data; Dementia; Development; Effectiveness; Ensure; Evaluation; Event; Feedback; Funding; Genetic; Geography; Goals; Government; Growth; Haplotypes; Human Resources; Induced pluripotent stem cell derived neurons; Institution; Interdisciplinary Study; International; Knowledge; Leadership; Los Angeles; Maintenance; Measures; Mission; Molecular; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neurobiology; Neuroglia; New York; Patient advocacy; Process; Proteomics; Regulation; Research; Research Personnel; Resources; Risk; Role; San Francisco; Science; Site; Structure; Tauopathies; Technology; Time; TimeLine; United States National Institutes of Health; Work; brain tissue; data exchange; data sharing; data sharing networks; design; innovation; interdisciplinary approach; medical schools; meetings; outreach; programs; tau Proteins; transcriptomics; web site

PROJECT SUMMARY (CORE A: ADMINISTRATIVE CORE) The purpose of the Administrative Core (Core A) is to ensure execution of our mission to conduct innovative, interdisciplinary research to identify and validate the molecular mechanisms contributing to tauopathy risk/protection associated with the H1/H2 haplotypes of the 17q21.31 region. The Center involves 3 geographically distributed sites in New York (Icahn School of Medicine at Mount Sinai), Los Angeles (UCLA) and San Francisco (UCSF). Interactions will occur at two levels: scientific (exchange of information and data, sharing of resources and specialized personnel) and administrative (organization of meetings and interactions within and outside the CWOW). The primary goal of Core A is to connect these physically separate sites by serving as a hub to facilitate interaction and communication between Core and Project leaders, investigators, and external scientific communities, and ensure efficient governance and oversight of the Center. This Core will ensure optimal utilization of center resources through maximization of institutional strengths and national and global opportunities to broaden knowledge about the molecular mechanisms underlying risk/protection for sporadic and familial tauopathy associated with H1/H2 haplotypes. This core is responsible for articulating the research agenda and ensuring that it is effectively accomplished. Core A will accomplish this through a structure that includes an Executive Steering Committee (ESC) led by the Director (Dr. Alison Goate) and the two associate directors (Drs. Geschwind and Kampmann) as well as Core leaders. The ESC will insure that the CWOW, national and international FTD resources are leveraged to the advantage of the CWOW and those of the wider FTD community. An External Advisory Committee will provide guidance and review to the CWOW leadership and communicate with NINDS Program Staff. The leadership will assure that the Center is aware of national and international commitments as well as of opportunities to maximize our effectiveness. In this capacity specific responsibilities include financial, administrative and regulatory management. This Core will also oversee the growth of early stage investigators within the center. We propose two topically related Projects supported by three Research Cores that leverage cutting-edge proteomic and transcriptomic approaches in brain tissue and induced pluripotent stem cell derived neurons and glia to determine the mechanisms contributing to tauopathy risk/protection associated with the H1/H2 haplotypes of the 17q21.31 region. The Data Core (Core D) will serve as a hub for integrating all data produced by Projects and Cores to be shared within and outside the CWOW. Core A will organize regular meetings to ensure progress, open communication and resources are available to serve Project and Core goals, that Projects and Cores have maximal opportunity to interact, and that Projects and Cores progress according to timelines and meet benchmarks of accomplishment. Core A and the Data Core will work together to develop and maintain a Center website.

项目概要（核心A：行政核心） 管理核心（核心A）的目的是确保执行我们的使命，进行创新、 跨学科研究，以确定和验证有助于tau蛋白病的分子机制 与17q21.31区域的H1/H2单倍型相关的风险/保护。该中心涉及3 地理分布在纽约（西奈山伊坎医学院）、洛杉矶（UCLA）的研究中心 和旧金山弗朗西斯科（UCSF）。将在两个层面上开展互动：科学（信息和数据交流， 共享资源和专门人员）和行政（组织会议和互动 在CWOW内和CWOW外）。核心A的主要目标是通过以下方式连接这些物理上独立的站点 作为一个枢纽，促进核心和项目领导人，调查人员， 和外部科学界，并确保中心的有效治理和监督。这一核心将 通过最大限度地发挥机构优势和国家优势， 全球机会，以扩大对潜在风险/保护的分子机制的知识， 与H1/H2单倍型相关的散发性和家族性tau蛋白病。这个核心负责阐明 研究计划，并确保其有效实施。核心A将通过一个结构来实现这一点 其中包括一个由主任（艾莉森·高特博士）领导的执行指导委员会（ESC）， 副董事（Geschwind博士和Kampmann博士）以及核心领导人。ESC将确保 CWOW、国家和国际FTD资源被用于CWOW和 更广泛的FTD社区。外部咨询委员会将提供指导和审查， CWOW领导层，并与NINDS项目人员沟通。领导层将确保中心 我们意识到国家和国际承诺以及最大限度地发挥我们效力的机会。在 这一能力的具体职责包括财务、行政和监管管理。这 核心还将监督中心内早期研究人员的成长。我们提出两个专题 相关项目由三个研究核心支持，利用尖端的蛋白质组学 和转录组学方法在脑组织和诱导多能干细胞衍生的神经元和神经胶质细胞中的应用 以确定与H1/H2单倍型相关的tau蛋白病风险/保护的机制， 17q21.31区域。数据核心（核心D）将作为一个中心，整合项目产生的所有数据 以及在CWOW内部和外部共享的核心。核心A将定期组织会议以确保 进度、开放的沟通和资源可用于服务项目和核心目标， 核心有最大的互动机会，项目和核心根据时间表进行， 达到业绩基准。核心A和数据核心将共同开发和维护一个 中心网站。