Core A: Administrative

项目总结(核心A：行政核心) 行政核心(核心A)的目的是确保执行我们的使命，进行创新， 跨学科研究，以确定和验证相互作用的分子机制 与17q21.31区域H1/H2单倍型相关的风险/保护。该中心涉及3个 纽约(西奈山伊坎医学院)、洛杉矶(加州大学洛杉矶分校)的地理分布地点 旧金山(加州大学旧金山分校)。互动将在两个层面上发生：科学(信息和数据交换， 共享资源和专门人员)和行政(组织会议和互动 在CWow内外)。核心A的主要目标是通过以下方式连接这些物理上分离的站点 作为中心，促进核心和项目负责人、调查人员、 和外部科学界，并确保对该中心的有效治理和监督。这一核心将 通过最大限度地利用机构优势和国家和 全球机会，以扩大关于潜在风险/保护的分子机制的知识 与H1/H2单倍型相关的散发性和家族性互补性疾病。这一核心负责阐明 研究议程并确保其有效完成。核心A将通过一个结构来实现这一点 这包括由主任(艾莉森·戈特博士)领导的执行指导委员会(ESC)和两人 副主任(Geschind博士和Kampmann博士)以及核心领导者。ESC将确保 CWow、国内和国际FTD资源被利用到CWow和那些 更广泛的FTD社区。外部咨询委员会将提供指导和审查，以 CWow领导并与NINDS计划人员沟通。领导层将保证该中心 认识到国家和国际承诺以及最大限度地提高我们效力的机会。在……里面 该能力的具体职责包括财务、行政和监管管理。这 CORE还将监督该中心内早期调查人员的成长。我们在主题上提出了两个 由三个利用尖端蛋白质组学的研究核心支持的相关项目 和转录转录方法在脑组织和诱导多能干细胞来源的神经元和神经胶质细胞 确定与h1/h2单倍型相关的互变风险/保护机制 17q21.31区域。数据核心(核心D)将成为整合项目产生的所有数据的枢纽 以及要在CWow内外共享的核心。核心A将定期组织会议，以确保 进度、开放的沟通和资源可用于服务于项目和核心目标、项目和 核心有最大的互动机会，项目和核心按照时间表和 达到成就的基准。核心A和数据核心将共同开发和维护 中心网站。

PROJECT SUMMARY (CORE A: ADMINISTRATIVE CORE) The purpose of the Administrative Core (Core A) is to ensure execution of our mission to conduct innovative, interdisciplinary research to identify and validate the molecular mechanisms contributing to tauopathy risk/protection associated with the H1/H2 haplotypes of the 17q21.31 region. The Center involves 3 geographically distributed sites in New York (Icahn School of Medicine at Mount Sinai), Los Angeles (UCLA) and San Francisco (UCSF). Interactions will occur at two levels: scientific (exchange of information and data, sharing of resources and specialized personnel) and administrative (organization of meetings and interactions within and outside the CWOW). The primary goal of Core A is to connect these physically separate sites by serving as a hub to facilitate interaction and communication between Core and Project leaders, investigators, and external scientific communities, and ensure efficient governance and oversight of the Center. This Core will ensure optimal utilization of center resources through maximization of institutional strengths and national and global opportunities to broaden knowledge about the molecular mechanisms underlying risk/protection for sporadic and familial tauopathy associated with H1/H2 haplotypes. This core is responsible for articulating the research agenda and ensuring that it is effectively accomplished. Core A will accomplish this through a structure that includes an Executive Steering Committee (ESC) led by the Director (Dr. Alison Goate) and the two associate directors (Drs. Geschwind and Kampmann) as well as Core leaders. The ESC will insure that the CWOW, national and international FTD resources are leveraged to the advantage of the CWOW and those of the wider FTD community. An External Advisory Committee will provide guidance and review to the CWOW leadership and communicate with NINDS Program Staff. The leadership will assure that the Center is aware of national and international commitments as well as of opportunities to maximize our effectiveness. In this capacity specific responsibilities include financial, administrative and regulatory management. This Core will also oversee the growth of early stage investigators within the center. We propose two topically related Projects supported by three Research Cores that leverage cutting-edge proteomic and transcriptomic approaches in brain tissue and induced pluripotent stem cell derived neurons and glia to determine the mechanisms contributing to tauopathy risk/protection associated with the H1/H2 haplotypes of the 17q21.31 region. The Data Core (Core D) will serve as a hub for integrating all data produced by Projects and Cores to be shared within and outside the CWOW. Core A will organize regular meetings to ensure progress, open communication and resources are available to serve Project and Core goals, that Projects and Cores have maximal opportunity to interact, and that Projects and Cores progress according to timelines and meet benchmarks of accomplishment. Core A and the Data Core will work together to develop and maintain a Center website.