2022 Neurobiology of Brain Disorders GRC and GRS

项目概要/摘要 2022年脑疾病神经生物学的具体目标戈登研究会议（GRC）和戈登 研究研讨会（GRS）是为了促进既定和新兴领导人之间的对话， 神经退行性疾病，重点是阿尔茨海默病和相关痴呆症。联合主席艾莉森博士 Goate和伦纳德Petrucelli与过去的主席以及2022年副主席（Karen Duff博士和 克里斯托弗·肖）计划了九个口头会议：第一次会议-关于小说发展的主题演讲 基于血液的神经退行性疾病的生物标志物，会议2 -遗传和基因组方法， 神经退行性疾病，会议3 -神经退行性疾病的表观遗传学，会议4 -额颞 痴呆和ALS：机制，会议5 -帕金森病：机制，会议6 -阿尔茨海默氏症 疾病：机制，会议7 - Tauopathies：机制，&生物标志物，会议8 -生物标志物：诊断 和治疗诊断学，以及第9节-治疗方法。所有受邀发言者/讨论者均已确认 33个国家中有17个国家接受了关于妇女参与以及性别和多样性问题的建议 发言者/讨论者是妇女（51.5%），5人是非欧洲人（15%），5人（15%）是年轻调查员。11 受邀演讲者中有33%是国际人士。为便于演示，在GRC之前将有一个GRS 以及学员对前沿研究的讨论。由于主席和共同主席最优先重视 由受训人员和早期职业人士参与，将从提交的摘要中选出简短的演讲， 邀请演讲嘉宾。我们将尽一切努力增加代表性不足的少数民族的参与 与会者和发言人。与会者将在一个学院非正式互动 气氛和充足的自由时间，为参与者提供理想的环境来集思广益， 跨学科合作。本次研讨会的意义在于为国际社会提供一个独特的论坛， 一个致力于包括阿尔茨海默病和相关痴呆症在内的大脑疾病神经生物学的社区 讨论神经退行性变和衰老相关领域的最新进展和未来挑战 大脑紊乱这种应用与公共卫生的相关性在于，讨论将定义最 在神经变性疾病包括阿尔茨海默病和相关疾病领域中的重要问题 痴呆症跨越基础生物学和疾病机制，并帮助开发新的治疗方法， 战略布局这个GRC的长期目标是为这个社区提供一个一致的平台，以满足每个 两年来传播最新的发现，并制定最重要的问题， 年龄相关性神经退行性疾病的研究现状。

PROJECT SUMMARY/ABSTRACT The Specific Aims of the 2022 Neurobiology of Brain Disorders Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) are to promote dialogue among established and emerging leaders in neurodegenerative disease focusing on Alzheimer's disease and related dementias. The Co-Chairs, Drs. Alison Goate and Leonard Petrucelli, in consultation with past chairs, and the 2022 Vice Chairs (Drs. Karen Duff and Christopher Shaw) have planned nine oral sessions: Session 1 - Keynote Address on the Development of Novel Blood-Based Biomarkers for Neurodegenerative Disease, Session 2 - Genetic and Genomic Approaches to Neurodegenerative Disease, Session 3 - Epigenetics of Neurodegenerative Disease, Session 4 - Frontotemporal Dementia and ALS: Mechanisms, Session 5 - Parkinson's Disease: Mechanisms, Session 6 - Alzheimer's Disease: Mechanisms, Session 7 - Tauopathies: Mechanism, & Biomarkers, Session 8 - Biomarkers: Diagnosis and Theranostics, and Session 9 - Therapeutic Approaches. All invited speakers/discussants have confirmed their participation, and gender and diversity-related issues are addressed as 17 of 33 accepted speakers/discussants are women (51.5%), 5 are non-European (15%) and 5 (15%) are young investigators. 11 of the invited speakers are international (33%). The GRC will be preceded by a GRS to facilitate presentation and discussion of frontier research by trainees. As the Chairs and Co-Chairs place the highest priority on participation by trainees and early career individuals, short talks will be selected from submitted abstracts to complement invited speakers. We will make every effort to increase participation of under-represented minorities among conference participants and speakers. Conference participants will interact informally in a collegial atmosphere and have ample free time, providing ideal settings for participants to brainstorm and establish interdisciplinary collaborations. The significance of this GRC is to provide a unique forum for the international community working on the neurobiology of brain disorders including Alzheimer's disease and related dementias to discuss the latest advances and the future challenges in the field of neurodegeneration and aging related brain disorders. The relevance of this application to public health is that the discussions will define the most important questions in the field of neurodegenerative diseases including Alzheimer's disease and related dementias spanning basic biology and disease mechanisms and aid the development of novel therapeutic strategies. The long-term goal of this GRC is to provide a consistent platform for this community to meet every two years to disseminate the most recent discoveries and formulate the most important questions concerning the current state of the art research on age related neurodegenerative diseases.