2022 Neurobiology of Brain Disorders GRC and GRS

项目摘要/摘要 《2022年脑疾病神经生物学》戈登研究会议(GRC)和戈登 研究研讨会(GRS)旨在促进老牌和新兴领导人之间的对话 神经退行性疾病，主要表现为阿尔茨海默病和相关痴呆症。联席主席艾莉森博士 Goate和Leonard Petrucelli，与前任主席和2022年副主席(Karen Duff博士和 Christopher Shaw)计划了九次口头会议：第一次会议--关于小说发展的主旨演讲 神经退行性疾病的血液生物标记物，第2节-遗传和基因组方法 神经退行性疾病，第三场-神经退行性疾病的表观遗传学，第四场-额颞部 痴呆症和肌萎缩侧索硬化症：机制，课程5-帕金森氏病：机制，课程6-阿尔茨海默病 疾病：机制，会议7--疾病：机制，与生物标记物，会议8--生物标记物：诊断 和治疗学，以及第9次会议-治疗方法。所有受邀演讲者/讨论者已确认 他们的参与以及与性别和多样性有关的问题得到了33个国家中的17个国家的接受 发言者/讨论者为女性(51.5%)，5名非欧洲人(15%)，5名(15%)为年轻调查人员。11. 被邀请的演讲者中有33%是国际人士。GRC之前将有GRS，以便于介绍 以及学员对前沿研究的讨论。由于主席和联席主席将最优先事项放在 学员和职业生涯初期的个人参与，简短的演讲将从提交的摘要中挑选出来，以 补充特邀演讲者。我们将尽一切努力增加代表不足的少数群体的参与 在与会者和演讲者之间。会议参与者将在合议性会议中进行非正式互动 气氛浓厚，有充足的空闲时间，为参与者集思广益和建立 跨学科协作。GRC的意义在于为国际社会提供一个独特的论坛 社区致力于阿尔茨海默病和相关痴呆等脑疾病的神经生物学研究 讨论神经退行性变和衰老相关领域的最新进展和未来挑战 大脑紊乱。这项申请与公共卫生的相关性在于，讨论将定义最多 阿尔茨海默病等神经退行性疾病领域的重要问题 痴呆跨越基础生物学和疾病机制，并有助于开发新的治疗方法 战略。这个GRC的长期目标是为这个社区提供一个一致的平台，以满足每个 两年的时间来传播最新的发现，并阐明关于 年龄相关性神经退行性疾病的研究现状。

PROJECT SUMMARY/ABSTRACT The Specific Aims of the 2022 Neurobiology of Brain Disorders Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) are to promote dialogue among established and emerging leaders in neurodegenerative disease focusing on Alzheimer's disease and related dementias. The Co-Chairs, Drs. Alison Goate and Leonard Petrucelli, in consultation with past chairs, and the 2022 Vice Chairs (Drs. Karen Duff and Christopher Shaw) have planned nine oral sessions: Session 1 - Keynote Address on the Development of Novel Blood-Based Biomarkers for Neurodegenerative Disease, Session 2 - Genetic and Genomic Approaches to Neurodegenerative Disease, Session 3 - Epigenetics of Neurodegenerative Disease, Session 4 - Frontotemporal Dementia and ALS: Mechanisms, Session 5 - Parkinson's Disease: Mechanisms, Session 6 - Alzheimer's Disease: Mechanisms, Session 7 - Tauopathies: Mechanism, & Biomarkers, Session 8 - Biomarkers: Diagnosis and Theranostics, and Session 9 - Therapeutic Approaches. All invited speakers/discussants have confirmed their participation, and gender and diversity-related issues are addressed as 17 of 33 accepted speakers/discussants are women (51.5%), 5 are non-European (15%) and 5 (15%) are young investigators. 11 of the invited speakers are international (33%). The GRC will be preceded by a GRS to facilitate presentation and discussion of frontier research by trainees. As the Chairs and Co-Chairs place the highest priority on participation by trainees and early career individuals, short talks will be selected from submitted abstracts to complement invited speakers. We will make every effort to increase participation of under-represented minorities among conference participants and speakers. Conference participants will interact informally in a collegial atmosphere and have ample free time, providing ideal settings for participants to brainstorm and establish interdisciplinary collaborations. The significance of this GRC is to provide a unique forum for the international community working on the neurobiology of brain disorders including Alzheimer's disease and related dementias to discuss the latest advances and the future challenges in the field of neurodegeneration and aging related brain disorders. The relevance of this application to public health is that the discussions will define the most important questions in the field of neurodegenerative diseases including Alzheimer's disease and related dementias spanning basic biology and disease mechanisms and aid the development of novel therapeutic strategies. The long-term goal of this GRC is to provide a consistent platform for this community to meet every two years to disseminate the most recent discoveries and formulate the most important questions concerning the current state of the art research on age related neurodegenerative diseases.