Precision magnetic hyperthermia by integrating magnetic particle imaging
通过集成磁粒子成像实现精确磁热疗
基本信息
- 批准号:10296182
- 负责人:
- 金额:$ 67.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAlgorithmsAnimal ModelAnimalsBiologicalBiomedical ResearchBreast Cancer ModelClinicalClinical TrialsColloidsComputer ModelsComputer softwareContrast MediaDiagnosisERBB2 geneEffectivenessEmerging TechnologiesEuropeanFiber OpticsFundingGelGlioblastomaGrantHeatingHistologyHumanHyperthermiaImageImaging technologyLiverLocationMagnetic Resonance ImagingMagnetic fluid hyperthermiaMagnetic nanoparticlesMagnetismMalignant NeoplasmsMalignant neoplasm of prostateMammary NeoplasmsMeasurementMetastatic Neoplasm to the LungMetastatic breast cancerMethodsModelingMusNanotechnologyNormal tissue morphologyPhysiologic pulsePositioning AttributePropertyRadiation therapyRattusRecurrenceRelaxationResearch PersonnelResistanceResolutionSamplingSignal TransductionSuspensionsSystemTechnologyTemperatureTestingTherapeuticTherapeutic EffectThermometryTimeTissuesToxic effectTracerTransgenic OrganismsTreatment EfficacyTumor BurdenValidationWidthbasecancer therapycandidate selectionclinical applicationclinically relevantcontrast enhanceddetection sensitivityhyperthermia treatmentimage guidedin vivoinstrumentationiron oxide nanoparticlemagnetic fieldnanotheranosticsparticlepre-clinicalrectalsensortechnology developmenttheranosticstreatment planningtumortumor growth
项目摘要
Precision magnetic hyperthermia by integrating magnetic particle imaging
Magnetic activation of magnetic iron oxide nanoparticles (MIONPs) offers considerable potential for numerous
biomedical applications. Approved clinical applications include contrast enhancement for magnetic resonance
imaging (MRI) and magnetic fluid hyperthermia (MFH) for cancer treatment. MIONPs are T2 negative contrast
agents which have been clinically available for MRI since the late 1980s where very low tissue concentrations
(<100 g Fe/g tissue) are needed for imaging. MFH is a powerful nanotechnology-based treatment that enhances
radiation therapy (RT). It comprises local heating of tissue by activating MIONPs with an external alternating
magnetic field (AMF), enabling treatment anywhere in the body. Human clinical trials demonstrated benefits of
MFH for prostate cancer; and, overall survival benefits with RT in recurrent glioblastoma (GBM) resulted in
European approval in 2010. However, current MFH effectiveness is limited by the inability to visualize MIONP
distribution during MFH, resulting in poor AMF control of MIONP heating, reduced therapeutic efficacy, and
unwanted off-target toxicity. An integrated MIONP imaging-MFH technology that provides spatial control of the
MFH treatment volume will substantially advance the clinical use of theranostic MIONPs. Magnetic particle
imaging (MPI) is an emerging imaging technology that directly quantitates MIONP concentration in tissue with
similar or greater sensitivity as MRI. The main magnet in an MPI scanner produces a strong magnetic field
gradient containing a region where the magnetic field is approximately zero, i.e. the Field Free Region (FFR).
MIONPs in the FFR are magnetically unsaturated and can produce a signal in a receiver coil, while MIONPs
elsewhere are magnetically saturated and produce no signal. Images are produced by rastering the FFR across
the sample. The FFR used for imaging can be used to localize MFH. By applying a magnetic field gradient and
AMF, only MIONPs inside the FFR will heat while MIONPs outside the FFR are saturated and do not heat. MPI
and MFH are compatible enabling mm-precision spatial control of MFH. Our objective is to develop an integrated
MPI/MFH workflow that incorporates imaging-guided treatment planning with optimal theranostic MIONPs for
preclinical biomedical research with small animal (mouse and rat) models. We aim to achieve our objectives by
purchasing a HYPER AMF system that will be used with our recently acquired Momentum MPI scanner (funded
by a S10 shared instrumentation grant). Our specific aims are: (Aim 1) Identify MIONPs having ideal physical
and magnetic properties for MPI/MFH; (Aim 2) Develop MPI-guided MFH treatment using computational
modeling and amplitude modulation; (Aim 3) Demonstrate increased therapeutic efficacy of theranostic
MPI/MFH in vivo. While the primary objective of the proposed effort is technology development, successful
completion of the aims will provide biomedical researchers the ability to realize theranostic applications with
magnetic nanoparticles.
集成磁粒子成像的精密磁热疗
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeff W. Bulte其他文献
Jeff W. Bulte的其他文献
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{{ truncateString('Jeff W. Bulte', 18)}}的其他基金
Precision magnetic hyperthermia by integrating magnetic particle imaging
通过集成磁粒子成像实现精确磁热疗
- 批准号:
10667448 - 财政年份:2021
- 资助金额:
$ 67.7万 - 项目类别:
Precision magnetic hyperthermia by integrating magnetic particle imaging
通过集成磁粒子成像实现精确磁热疗
- 批准号:
10415219 - 财政年份:2021
- 资助金额:
$ 67.7万 - 项目类别:
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor Therapy
用于增强成像和肿瘤治疗的治疗诊断纳米颗粒的细胞内自组装
- 批准号:
10207626 - 财政年份:2020
- 资助金额:
$ 67.7万 - 项目类别:
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor Therapy
用于增强成像和肿瘤治疗的治疗诊断纳米颗粒的细胞内自组装
- 批准号:
10400220 - 财政年份:2020
- 资助金额:
$ 67.7万 - 项目类别:
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor Therapy
用于增强成像和肿瘤治疗的治疗诊断纳米颗粒的细胞内自组装
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10063659 - 财政年份:2020
- 资助金额:
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