Study to Explore Early Development (SEED) Follow up Studies, Components A, B, D & E

探索早期发育的研究 (SEED) 后续研究，组成部分 A、B、D

• 批准号: 10299758
• 负责人: M Daniele Fallin
• 金额: $ 119.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10299758
• 关键词: Study; Explore; Early; Development; SEED

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case-control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co-occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The Maryland SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in Maryland and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

自闭症谱系障碍（ASD）是一种神经发育障碍，影响约1.5%的儿童 在美国患有ASD的个体在社交沟通或兴趣受限方面存在缺陷， 重复行为;但严重程度和模式差异很大，并传达终身损害的一些。是 目前尚不清楚ASD的表现如何从幼儿期到青春期或成年期发生变化。的原因 ASD的基因也是未知的，尽管大量的证据支持这两个基因的贡献， 环境因素这些知识差距的存在是因为迄今为止美国的研究缺乏样本量， 数据收集的深度，或适当的生命周期时间来解决这些问题。早期探索研究 现在，SEED能够解决这些先前的限制。SEED是一项大型病例对照研究， 该项目分三个阶段在8个州实施。收集的种子 关于儿童的核心ASD症状，认知状态和合并症的存在的详细数据 幼儿期，沿着与孕产妇健康和围产期环境有关的广泛风险因素， 以及基因组学。SEED样本包括2044名ASD儿童，1950名非ASD儿童， 发育障碍（DD）和2285名人口控制儿童（POP），使其成为最大的病因 ASD在美国的研究最近的辅助研究--SEED Teen Pilot和SEED COVID研究--即将推出 分别为一些种子环境数据库参与者增加关于青少年健康和流行病后果的数据。 这里提出的工作，种子后续研究（SEED FU），将最大限度地发挥现有的种子数据的影响 通过分析ASD表型的特征，并评估遗传和 可改变的风险因素。SEED FU还将促进儿童中期、青春期和 成年早期以表征ASD表型在发育阶段的变化，以及相关的 健康、教育和服务需求贯穿整个生命早期。这些数据将进一步推动前瞻性 分析早期生活因素与儿童后期到成年早期结果之间的关联。 研究与生命过程表型亚组相关的风险因素也可能有助于阐明以前的病因学 在ASD病例对照研究中设盲。马里兰州种子团队与种子网络的 协作基础设施和广泛的现有数据资源，将确保成功实施 马里兰州的SEED FU研究，并为整个网络的成功做出贡献。种子是强大的， 对我们理解复杂自闭症表型和识别相关因素的重大贡献 有ASD风险的人群。通过SEED FU获得的知识将大大提高我们预防 不利的发育结果，并支持自闭症谱系障碍患者及其家人，以确保最佳的 在成年早期保持健康。