Study to Explore Early Development (SEED) Follow up Studies, Components A, B, D & E

探索早期发育的研究 (SEED) 后续研究，组成部分 A、B、D

• 批准号: 10299758
• 负责人: M Daniele Fallin
• 金额: $ 119.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10299758
• 关键词: Study; Explore; Early; Development; SEED

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case-control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co-occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The Maryland SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in Maryland and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

自闭症谱系障碍 (ASD) 是一种神经发育障碍，影响约 1.5% 的儿童 在美国。患有自闭症谱系障碍 (ASD) 的人会出现社交沟通障碍或兴趣受限， 重复行为；但严重程度和模式差异很大，对某些人来说可能会造成终生损害。这是 目前还不清楚 ASD 的表现如何从幼儿期到青春期或成年期发生变化。原因 尽管大量证据支持基因和自闭症谱系障碍的贡献，但自闭症谱系障碍的影响尚不清楚。 环境因素。这些知识差距的存在是因为美国迄今为止的研究缺乏样本量， 数据收集的深度，或适当的生命历程时间来解决这些问题。早期探索的研究 Development (SEED) 现在能够解决这些先前的限制。 SEED 是一项大型病例对照研究 2-5 岁儿童及其家庭，分三个阶段在八个州实施。已收集种子 有关儿童核心自闭症谱系障碍症状、认知状态以及同时发生的病症的详细数据 幼儿期，以及与孕产妇健康和围产期环境相关的广泛危险因素 以及基因组学。 SEED 样本包括 2044 名 ASD 儿童和 1950 名非 ASD 儿童 发育障碍 (DD) 和 2285 名人口控制儿童 (POP)，使其成为最大的病因 美国自闭症谱系障碍（ASD）研究。最近的辅助研究 - SEED 青少年试点和 SEED COVID 研究 - 即将推出 分别为一些 SEED 参与者添加有关青少年健康和流行病后果的数据。 这里提出的工作，即 SEED 后续研究 (SEED FU)，将最大限度地发挥现有 SEED 数据的影响 通过分析自闭症谱系障碍表型特征并评估遗传和自闭症谱系障碍之间的潜在相互作用 可改变的风险因素。 SEED FU 还将促进儿童中期、青春期和青少年时期的新数据收集 成年早期来表征跨发育阶段 ASD 表型的变化，以及相关的 整个生命早期的健康、教育和服务需求。这些数据将进一步使未来 通过成年早期的结果分析早期生活因素与童年后期之间的关联。 研究与生命历程表型亚组相关的危险因素也可能有助于先前阐明病因 在 ASD 病例对照研究中被掩盖。马里兰州 SEED 团队与 SEED Network 的合作 协作基础设施和广泛的现有数据资源将确保成功实施 马里兰州的 SEED FU 研究并为整个网络的成功做出贡献。 SEED 具有强大的制作能力 对我们理解复杂的自闭症表型和识别相关因素做出了重大贡献 人群中存在 ASD 风险。通过 SEED FU 获得的知识将极大地提高我们预防疾病的能力 不良的发育结果，并支持自闭症谱系障碍患者及其家人，以确保最佳的 整个成年早期的福祉。