Missouri Study to Explore Early Development (SEED) Follow-Up

密苏里州研究探索早期发育 (SEED) 后续行动

• 批准号: 10408656
• 负责人: JOHN N. CONSTANTINO
• 金额: $ 31.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408656
• 关键词: Missouri; Study; Explore; Early; Development

Project Summary Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children's core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The MO SEED Team in combination with the SEED Network's collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in Missouri and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

项目摘要 自闭症谱系障碍(ASD)是一种神经发育障碍，影响大约1.5%的 美国的儿童。患有自闭症的人在社交方面有缺陷或受限 兴趣和重复行为；但严重程度和模式差异很大，并传递终身损害 一些。目前尚不清楚ASD的表现如何从儿童早期进入青春期或成年期。 ASD的病因也是未知的，尽管大量证据支持这两个基因的作用 以及环境因素。这些知识差距的存在是因为美国的研究到目前为止还缺乏 样本大小、数据收集的深度或适当的生命历程时间安排来解决这些问题。这项研究 探索早期开发(SEED)现在能够解决这些先前的限制。种子是个大案子- 对2-5岁儿童及其家庭的对照研究，分三个阶段在八个州实施。 SEED收集了有关儿童ASD核心症状、认知状况和是否存在共同障碍的详细数据 儿童早期的发病情况，以及与孕产妇健康和 围产期环境以及基因组学。种子样本包括2044名患有自闭症的儿童，1950名儿童 患有非自闭症发育障碍(DD)的儿童和2285名人口控制儿童(POP)，使这成为 美国最大的ASD病因学研究。最近的辅助研究-种子青少年试点和种子冠状病毒 研究--不久将分别增加关于青少年健康和大流行后果的数据， 一些种子选手。这里提出的工作，种子后续研究(SEED FU)，将最大限度地 通过分析ASD表型特征和评估潜力，现有种子数据的影响 遗传和可改变的风险因素之间的相互作用。Seed Fu还将促进新的数据收集 儿童中期、青春期和成年期早期ASD表型变化的特征 发展阶段，以及整个早期生命过程中相关的健康、教育和服务需求。 这些数据将进一步支持对早期生活因素和后来的生活因素之间的关联的前瞻性分析 从童年到成年早期的结果。研究危险因素与生命过程表型的关系 亚组也可能有助于阐明先前在ASD病例对照研究中掩盖的病因。MO种子 与种子网络的协作基础设施和大量现有数据相结合的团队 资源，将确保在密苏里州成功实施种子FU研究，并为 在整个网络中取得成功。SEED对我们的理解做出了重大贡献 研究人群中复杂的自闭症表型和识别与自闭症风险相关的因素。这个 通过种子FU获得的知识将极大地提高我们预防不良发育后果的能力 支持自闭症患者及其家人确保成年初期的最佳福祉。