GPR55 receptor signaling in binge alcohol drinking behavior

项目摘要 酗酒，特别是酗酒(酒精)，是一个主要的公共卫生问题。近期 研究表明，在青春期和年轻人中，酗酒的发生率很高。像大多数人一样 滥用药物，酒精的使用通常在青春期开始，导致短期和长期的 对健康造成负面影响，包括增加患酒精使用障碍(AUD)的风险。 尽管在了解AUD的神经生物学方面取得了重大进展，但AUD的作用 酗酒对大脑和导致行为缺陷的神经机制的影响尚不清楚 清楚地明白了。最近的研究表明，孤儿G蛋白偶联受体55(GPR55) 信号在健康和疾病中发挥着重要作用。然而，GPR55信号在暴饮暴食中的作用 饮酒目前还不为人所知。这项拟议中的研究集中在了解酗酒的影响。 饮酒对青春期和青春期大脑GPR55信号的影响，并评估药物是否 以GPR55为靶点，利用C57BL/6J小鼠模型调控酗酒。这项研究将提供 进一步深入了解酗酒的神经机制，这一发现将有助于 开发对AUD有效的治疗干预措施。

Project Summary Alcohol abuse, particularly binge alcohol (ethanol) drinking, is a major public health concern. Recent studies have revealed a high prevalence of binge drinking in adolescence and young adults. Like most drugs of abuse, ethanol use is usually initiated in adolescence leading to short-term as well as long-term negative health consequences, including increased risk for the development of alcohol use disorder (AUD). Although significant advances have been made in understanding the neurobiology of AUD, the effect of binge drinking on the brain and neuronal mechanisms contributing to the behavioral deficits are not yet clearly understood. Recent studies have suggested that an orphan G-protein-coupled receptor 55 (GPR55) signaling plays an important role in health and diseases. However, the role of GPR55 signaling in binge alcohol drinking is currently unknown. The proposed research is focused on understanding the effects of binge alcohol drinking in both adolescence and young adulthood on brain GPR55 signaling, and assess if the drugs targeted to GPR55 regulate binge ethanol drinking using a C57BL/6J mouse model. This study will provide further insight into neuronal mechanism of binge alcohol drinking, and the findings would assist in the development of effective therapeutic interventions for AUD.