Administrative Core

项目摘要--行政核心 杜克/德克萨斯大学西南胶质母细胞瘤治疗网络(GTN)团队将完成临床前 胶质母细胞瘤(GBM)治疗新方法的开发及生物活性研究 这种药物处于早期临床试验阶段。为支持这一目标，该行政核心负责 监督、整合、协调和支持项目1和2以及共享的生物标记、生物信息学 和生物储存库核心。行政核心将监督组织基础设施、所有 各组成部分，并开展日常行政活动；作为与所有内部和外部的联络 ；为编写报告、手稿和规范性文件提供支助；促进 团队科学，通过定期会议、研讨会和 其他互动。它还将提供财务管理，以确保及时进行财务会计和报告。 根据大学和国家卫生研究院的政策；提供监管支持，以确保符合机构、国家、 和联邦研究指南；监督数据操作，以确保使用数据来源的最佳做法 和完整性(例如，SOP、GCP等监控标准)；通过监控提供科学管理 研究进展/生产率，并能够有效利用与科学里程碑相关的共享资源核心 和预算里程碑；进行持续的严格计划评估，由以下人员提供指导和指导 指导委员会和内部咨询委员会；解决冲突；确定具体出版物和 数据分发策略。关键的是，这个核心还将监督与GTN U19其他资助站点的互动， 与网络协调中心的沟通，以及年度跨U19试点项目资金的使用。这 CORE的结构是为了减少行政负担，使调查人员能够专注于开发一种新的 一种新型端粒酶介导的端粒靶向药物6-硫代-2‘-硫代脱氧核糖核酸治疗成人基底膜的方法 脱氧鸟苷(6-硫代-DG)，通过高质量、严谨、高效的研究。

PROJECT SUMMARY – Administrative Core This Duke/UT Southwestern Glioblastoma Therapeutics Network (GTN) team will complete pre-clinical development of a novel treatment for patients with glioblastoma (GBM) and investigate the biologic activity of this agent in an early-phase clinical trial. In support of this goal, this Administrative Core is responsible for overseeing, integrating, coordinating, and supporting Projects 1 and 2 and the shared Biomarker, Bioinformatics and Biorepository Core. The Administrative Core will oversee the organizational infrastructure, integration of all components, and carry out day-to-day administrative activities; serve as the liaison with all internal and external constituencies; provide support for preparation of reports, manuscripts, and regulatory documents; and foster team science by facilitating collaboration and smooth communication through regular meetings, seminars, and other interactions. It will also provide fiscal management to ensure timely financial accounting and reporting according to university and NIH policies; provide regulatory support to ensure compliance with institutional, state, and federal research guidelines; oversee data operations to ensure use of best practices for data provenance and integrity (e.g., monitoring standards such as SOPs, GCP); provide scientific management by monitoring research progress/productivity and enable effective use of shared resource cores relative to scientific milestones and budget milestones; conduct ongoing rigorous Program evaluations, with guidance and direction provided by a Steering Committee and an Internal Advisory Board; resolve conflict; and delineate specific publication and data distribution policies. Critically, this Core will also oversee interactions with other funded GTN U19 sites, communication with Network Coordination Center, and the use of yearly trans-U19 Pilot Project Funds. This Core is structured to reduce administrative burden, allowing investigators to focus on developing a novel approach for treating adult GBM using an innovative telomerase-mediated telomere-targeting drug, 6-thio-2′- deoxyguanosine (6-thio-dG), through high-quality, rigorous, and efficient research.