Analytical Immunopharmacology

分析免疫药理学

基本信息

项目摘要

PROJECT SUMMARY – CORE A The Analytical Immunopharmacology Core (Core A) is designed to meet the specific drug and biologic therapeutic development needs of each of the U19 Research Projects and at the same time draw on the strength of the existing City of Hope Comprehensive Cancer Center (COHCCC) cores without unnecessary duplication of services. Core A will work closely and synergistically with COHCCC cores, as well as with the U19 Administrative Core and the Molecular Profiling and Bioinformatics Core (Core B) to provide exceptional support for all of the proposed Research Projects and inter-U19 collaborations. The overarching goals of Core A are to assist the Glioblastoma Therapeutics Network (GTN) U19 Project Leaders with pharmacokinetic (PK) and pharmacodynamic (PD) correlative studies performed in support of the proposed clinical trials. The work will be accomplished by leveraging the Core’s significant expertise in intracerebral microdialysis (ICMD), analytical chemistry, and analytical immunochemistry, as well as its access to state-of-the-art instrumentation. The overall purpose will be achieved through the following Specific Aims: Aim 1. Provide conceptual and analytical support to U19 investigators for correlative neuro-PK analyses (e.g., analysis of drugs and metabolites in the CNS). Support provided by Core A to U19 investigators under this aim will include all aspects of ICMD neuro-PK studies, including experimental design, analytical method development, sample analysis, and final interpretation of the data. Core A is staffed by highly trained personnel and equipped with analytical instrumentation that will be ideal for the quantitative analyses of small molecules (e.g., LC-MS/MS and ICP-MS/MS). Aim 2. Provide conceptual and analytical support to U19 investigators for their correlative neuro-PD analyses (e.g., analysis of biomarkers of drug response in the CNS). Support provided by Core A to U19 investigators under this aim will include all aspects of ICMD neuro-PD studies, including experimental design, analytical method development, sample analysis, and final interpretation of the data. Core A will provide a spectrum of immunoassay platforms (e.g., Luminex and ELISA) in the context of ICMD neuro-PD studies in support of the proposed clinical trials.
项目总结-核心a

项目成果

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TIMOTHY W SYNOLD其他文献

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{{ truncateString('TIMOTHY W SYNOLD', 18)}}的其他基金

Analytical Immunopharmacology
分析免疫药理学
  • 批准号:
    10488204
  • 财政年份:
    2021
  • 资助金额:
    $ 1.84万
  • 项目类别:
Analytical Immunopharmacology
分析免疫药理学
  • 批准号:
    10696183
  • 财政年份:
    2021
  • 资助金额:
    $ 1.84万
  • 项目类别:
UPLC with Tandem MS for Sensitive Quantitative Analysis of Small Molecules
UPLC 与串联 MS 对小分子进行灵敏的定量分析
  • 批准号:
    7215071
  • 财政年份:
    2007
  • 资助金额:
    $ 1.84万
  • 项目类别:
SXR as a Therapeutic Target in Drug Resistant Cancer
SXR 作为耐药癌症的治疗靶点
  • 批准号:
    6333997
  • 财政年份:
    2001
  • 资助金额:
    $ 1.84万
  • 项目类别:
SXR as a Therapeutic Target in Drug Resistant Cancer
SXR 作为耐药癌症的治疗靶点
  • 批准号:
    6515052
  • 财政年份:
    2001
  • 资助金额:
    $ 1.84万
  • 项目类别:
Analytical Pharmacology Core
分析药理学核心
  • 批准号:
    10059203
  • 财政年份:
    1997
  • 资助金额:
    $ 1.84万
  • 项目类别:
Analytical Pharmacology
分析药理学
  • 批准号:
    10628586
  • 财政年份:
    1997
  • 资助金额:
    $ 1.84万
  • 项目类别:
Analytical Pharmacology Core
分析药理学核心
  • 批准号:
    10328527
  • 财政年份:
    1997
  • 资助金额:
    $ 1.84万
  • 项目类别:

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