Analytical Immunopharmacology
分析免疫药理学
基本信息
- 批准号:10306302
- 负责人:
- 金额:$ 1.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-13 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAnalytical ChemistryBioinformaticsBiological AssayBiological MarkersBiological ProductsBiological Response Modifier TherapyBlood - brain barrier anatomyBrainCentral Nervous System NeoplasmsCerebrospinal FluidCity of Hope Comprehensive Cancer CenterClinicalClinical TrialsCollaborationsComplexConsultationsCorrelative StudyData AnalysesDevelopmentDrug Delivery SystemsDrug KineticsElementsEnrollmentEnzyme-Linked Immunosorbent AssayExperimental DesignsFutureGlioblastomaGoalsHigh Pressure Liquid ChromatographyHuman ResourcesImmunoassayImmunochemistryImmunologicsInductively Coupled Plasma Mass SpectrometryIntercellular FluidInvestigationKnowledgeLigandsLiquid substanceMass FragmentographyMicrodialysisMolecular ProfilingNeuraxisPatientsPharmaceutical PreparationsPharmacodynamicsPharmacology StudyPlasmaProteinsProtocols documentationResearchResearch DesignResearch PersonnelResearch Project GrantsSamplingSerumServicesTechniquesTherapeuticTimeTrainingTranslational ResearchWorkWritinganalytical methodchemokineclinical developmentcytokinedesigneffective therapyexperienceimmunopharmacologyinstrumentationinterstitialmethod developmentnovelnovel therapeutic interventionnovel therapeuticspharmacodynamic modelpharmacokinetics and pharmacodynamicspreclinical developmentprogramsresponsesmall moleculesmall molecule inhibitortherapeutic developmenttumor
项目摘要
PROJECT SUMMARY – CORE A
The Analytical Immunopharmacology Core (Core A) is designed to meet the specific drug and biologic
therapeutic development needs of each of the U19 Research Projects and at the same time draw on the strength
of the existing City of Hope Comprehensive Cancer Center (COHCCC) cores without unnecessary duplication
of services. Core A will work closely and synergistically with COHCCC cores, as well as with the U19
Administrative Core and the Molecular Profiling and Bioinformatics Core (Core B) to provide exceptional support
for all of the proposed Research Projects and inter-U19 collaborations. The overarching goals of Core A are to
assist the Glioblastoma Therapeutics Network (GTN) U19 Project Leaders with pharmacokinetic (PK) and
pharmacodynamic (PD) correlative studies performed in support of the proposed clinical trials. The work will be
accomplished by leveraging the Core’s significant expertise in intracerebral microdialysis (ICMD), analytical
chemistry, and analytical immunochemistry, as well as its access to state-of-the-art instrumentation. The overall
purpose will be achieved through the following Specific Aims:
Aim 1. Provide conceptual and analytical support to U19 investigators for correlative neuro-PK analyses
(e.g., analysis of drugs and metabolites in the CNS). Support provided by Core A to U19 investigators under
this aim will include all aspects of ICMD neuro-PK studies, including experimental design, analytical method
development, sample analysis, and final interpretation of the data. Core A is staffed by highly trained personnel
and equipped with analytical instrumentation that will be ideal for the quantitative analyses of small molecules
(e.g., LC-MS/MS and ICP-MS/MS).
Aim 2. Provide conceptual and analytical support to U19 investigators for their correlative neuro-PD
analyses (e.g., analysis of biomarkers of drug response in the CNS). Support provided by Core A to U19
investigators under this aim will include all aspects of ICMD neuro-PD studies, including experimental design,
analytical method development, sample analysis, and final interpretation of the data. Core A will provide a
spectrum of immunoassay platforms (e.g., Luminex and ELISA) in the context of ICMD neuro-PD studies in
support of the proposed clinical trials.
项目总结-核心a
项目成果
期刊论文数量(0)
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{{ truncateString('TIMOTHY W SYNOLD', 18)}}的其他基金
UPLC with Tandem MS for Sensitive Quantitative Analysis of Small Molecules
UPLC 与串联 MS 对小分子进行灵敏的定量分析
- 批准号:
7215071 - 财政年份:2007
- 资助金额:
$ 1.84万 - 项目类别:
SXR as a Therapeutic Target in Drug Resistant Cancer
SXR 作为耐药癌症的治疗靶点
- 批准号:
6333997 - 财政年份:2001
- 资助金额:
$ 1.84万 - 项目类别:
SXR as a Therapeutic Target in Drug Resistant Cancer
SXR 作为耐药癌症的治疗靶点
- 批准号:
6515052 - 财政年份:2001
- 资助金额:
$ 1.84万 - 项目类别:
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