Administration and Data Analytic Core

管理和数据分析核心

• 批准号: 10304504
• 负责人: Amy Caroline Justice
• 金额: $ 32.23万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304504
• 关键词: Address; Aging; Alcohol consumption; Alcohols; Artificial Intelligence; Authorship; Behavioral; Biological Markers; Biometry; Caring; Clinical; Cohort Studies; Collaborations; Common Data Element; Communication; Data; Data Analytics; Data Sources; Development Plans; Drug Prescriptions; Electronic Health Record; Ensure; Extended Family; Family; Funding; Genetic; Goals; HIV; HIV Infections; Health; Healthcare; Healthcare Systems; High Performance Computing; Individual; Infrastructure; International; Intervention Studies; Leadership; Libraries; Machine Learning; Medical; Methodology; Methods; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Observational Study; Outcome; Peer Review; Pharmaceutical Preparations; Phenotype; Polypharmacy; Positioning Attribute; Procedures; Productivity; Protocols documentation; Publications; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Seasons; Services; Statistical Methods; Surveys; Time; Training and Education; United States Department of Veterans Affairs; United States National Institutes of Health; Validation; Veterans; alcohol research; analytical method; career development; cohort; data access; data cleaning; data management; data sharing; data standards; diverse data; experience; indexing; motivational enhancement therapy; programs; substance use; translational study

HARP ADA PROJECT SUMMARY Built on two decades of experience with large coordinated NIAAA-funded research projects on HIV and alcohol, The Veterans Aging Cohort Study (VACS) and our extended family of large, well characterized, national Veterans Healthcare Administration (VA) Cohorts (VACo Family) offer an unprecedented resource for the study of alcohol among people aging with and without HIV infection. Derived from Electronic Health Record (EHR), and subjected to rigorous data cleaning and phenotype validation, the VACo Family shares common data elements, including 20 years of longitudinal data on alcohol and health outcomes; it also includes behaviorally similar uninfected individuals, allowing us to characterize the role of HIV infection in determining alcohol associated outcomes; and supports targeted translational and intervention studies. To support excellence in the questions addressed, study design and analyses, we have cultivated an international collaborative network of experts. This well-established infrastructure has resulted in exceptional productivity. Our investigators have used data from the VACo Family to produce >500 peer reviewed publications, cited >26,000 times (h-index 79). We have successfully coordinated observational and intervention studies focused on the role of alcohol in determining modifiable outcomes among people aging with and without HIV infection. We are also proud of the education, training, career development, and leadership experience we offer young investigators, many of whom have transitioned to independent NIH and VA funding. Our ongoing mission is to build and disseminate the evidence needed to optimize care for people aging with HIV (PAH) experiencing medical harm from alcohol through well-coordinated and fully integrated observational and intervention studies. With access to national EHR data including medication fill/refill data, we are uniquely positioned to study harms associated with concurrent use of alcohol and multiple medications (polypharmacy). In service to our larger mission, our Program Project application supports the creation of the HIV and Alcohol Research center focused on Polypharmacy (HARP) to address risks associated with harmful alcohol use and polypharmacy (AP risk). The ADA Core, organized into administrative and data analytic sections, is composed of seasoned study coordinators and an expanded group of experts in data management, high performance computing, biostatistics, and artificial intelligence. The Core will address the challenges of cleaning and analyzing large scale, longitudinal EHR data combined with other data sources (e.g., surveys, biomarkers, and genetics) to support observational and pilot intervention studies. By facilitating and informing data access, analytic approach, and maintaining excellent lines of communication with our larger network, the ADA Core will enhance the significance and impact of HARP, providing experience and resources not available were projects funded separately. With our experience, resources, and momentum, the ADA Core is uniquely positioned to address AP risk among PAH.

竖琴ADA项目摘要 建立在大型协调NIAAA资助的有关艾滋病毒和酒精的研究项目的经验的二十年之上， 退伍军人老化队列研究（VACS）和我们大型，特征，国家的大家庭 退伍军人医疗保健管理局（VA）同伙（VACO家族）为研究提供了前所未有的资源 患有和没有艾滋病毒感染的人的酒精。源自电子健康记录（EHR）， Vaco家族经过严格的数据清洁和表型验证，共享共同数据 要素，包括有关酒精和健康结果的20年纵向数据；它还包括行为 类似的未感染个体，使我们能够表征HIV感染在确定酒精中的作用 相关结果；并支持有针对性的翻译和干预研究。支持卓越 解决了问题，研究设计和分析，我们建立了一个国际协作网络 专家。建立良好的基础设施带来了出色的生产率。我们的调查人员有 使用Vaco家族的数据来生产> 500个同行评审的出版物，被引用> 26,000次（H-Index 79）。 我们成功地协调了观察性和干预研究，重点是酒精的作用 确定患有和没有艾滋病毒感染的患者的可改变结果。我们也为 教育，培训，职业发展和领导经验我们为年轻的调查员提供了许多 已经过渡到独立NIH和VA资金。我们持续的使命是建造和传播 优化对艾滋病毒（PAH）衰老的人的护理所需的证据 通过协调良好且完全整合的观察和干预研究。与国家接触 EHR数据在内，包括药物填充/补充数据，我们的位置是研究与 同时使用酒精和多种药物（多药）。为我们更大的使命服务 计划项目应用程序支持艾滋病毒和酒精研究中心的创建 多药（HARP）解决与有害饮酒和多药相关的风险（AP风险）。这 ADA Core组织为行政和数据分析部分，由经验丰富的研究组成 协调员和扩展的数据管理专家组，高性能计算， 生物统计学和人工智能。核心将应对清洁和分析大型的挑战 比例，纵向EHR数据与其他数据源（例如调查，生物标志物和遗传学）结合使用 支持观察和试点干预研究。通过促进和告知数据访问，分析方法， ADA核心将与我们更大的网络保持出色的沟通线路，将增强 竖琴的意义和影响，提供的经验和资源是没有资助的项目 分别地。凭借我们的经验，资源和势头，ADA核心在解决 PAH中的AP风险。