Administration and Data Analytic Core

管理和数据分析核心

• 批准号: 10686378
• 负责人: Amy Caroline Justice
• 金额: $ 27.95万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686378
• 关键词: Address; Aging; Alcohol consumption; Alcohols; Artificial Intelligence; Authorship; Behavioral; Biological Markers; Biometry; Caring; Clinical; Cohort Studies; Collaborations; Common Data Element; Communication; Data; Data Analytics; Data Sources; Development Plans; Drug Prescriptions; Education; Electronic Health Record; Ensure; Extended Family; Family; Funding; Genetic; Goals; HIV; HIV Infections; Health; Healthcare; Healthcare Systems; High Performance Computing; Individual; Infrastructure; International; Intervention Studies; Leadership; Libraries; Machine Learning; Medical; Methodology; Methods; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Observational Study; Outcome; Peer Review; Persons; Pharmaceutical Preparations; Phenotype; Polypharmacy; Positioning Attribute; Procedures; Productivity; Protocols documentation; Publications; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Seasons; Services; Statistical Methods; Surveys; Training; United States National Institutes of Health; Validation; Veterans; Veterans Health Administration; alcohol research; analytical method; career development; cohort; data access; data cleaning; data management; data sharing; data standards; diverse data; experience; indexing; motivational enhancement therapy; programs; substance use; translational study

HARP ADA PROJECT SUMMARY Built on two decades of experience with large coordinated NIAAA-funded research projects on HIV and alcohol, The Veterans Aging Cohort Study (VACS) and our extended family of large, well characterized, national Veterans Healthcare Administration (VA) Cohorts (VACo Family) offer an unprecedented resource for the study of alcohol among people aging with and without HIV infection. Derived from Electronic Health Record (EHR), and subjected to rigorous data cleaning and phenotype validation, the VACo Family shares common data elements, including 20 years of longitudinal data on alcohol and health outcomes; it also includes behaviorally similar uninfected individuals, allowing us to characterize the role of HIV infection in determining alcohol associated outcomes; and supports targeted translational and intervention studies. To support excellence in the questions addressed, study design and analyses, we have cultivated an international collaborative network of experts. This well-established infrastructure has resulted in exceptional productivity. Our investigators have used data from the VACo Family to produce >500 peer reviewed publications, cited >26,000 times (h-index 79). We have successfully coordinated observational and intervention studies focused on the role of alcohol in determining modifiable outcomes among people aging with and without HIV infection. We are also proud of the education, training, career development, and leadership experience we offer young investigators, many of whom have transitioned to independent NIH and VA funding. Our ongoing mission is to build and disseminate the evidence needed to optimize care for people aging with HIV (PAH) experiencing medical harm from alcohol through well-coordinated and fully integrated observational and intervention studies. With access to national EHR data including medication fill/refill data, we are uniquely positioned to study harms associated with concurrent use of alcohol and multiple medications (polypharmacy). In service to our larger mission, our Program Project application supports the creation of the HIV and Alcohol Research center focused on Polypharmacy (HARP) to address risks associated with harmful alcohol use and polypharmacy (AP risk). The ADA Core, organized into administrative and data analytic sections, is composed of seasoned study coordinators and an expanded group of experts in data management, high performance computing, biostatistics, and artificial intelligence. The Core will address the challenges of cleaning and analyzing large scale, longitudinal EHR data combined with other data sources (e.g., surveys, biomarkers, and genetics) to support observational and pilot intervention studies. By facilitating and informing data access, analytic approach, and maintaining excellent lines of communication with our larger network, the ADA Core will enhance the significance and impact of HARP, providing experience and resources not available were projects funded separately. With our experience, resources, and momentum, the ADA Core is uniquely positioned to address AP risk among PAH.

HARP ADA 项目摘要 建立在 NIAAA 资助的关于艾滋病毒和酒精的大型协调研究项目二十年的经验基础上， 退伍军人老龄化队列研究 (VACS) 和我们的大型、特征明确的全国性大家庭 退伍军人医疗保健管理局 (VA) 队列（VACo Family）为该研究提供了前所未有的资源 患有和未感染艾滋病毒的老年人中的酒精含量。源自电子健康记录 (EHR)， 并经过严格的数据清理和表型验证，VACo 系列共享通用数据 要素，包括 20 年酒精与健康结果的纵向数据；它还包括行为上的 类似的未感染者，使我们能够描述 HIV 感染在决定酒精含量方面的作用 相关结果；并支持有针对性的转化和干预研究。为了支持卓越 解决的问题、研究设计和分析，我们建立了一个国际合作网络 专家。这种完善的基础设施带来了卓越的生产力。我们的调查员有 使用 VACo Family 的数据制作了超过 500 份同行评审出版物，引用次数超过 26,000 次（h 指数 79）。 我们成功地协调了观察和干预研究，重点关注酒精在 确定感染或未感染艾滋病毒的老年人的可改变的结果。我们也为此感到自豪 我们为年轻的研究人员提供教育、培训、职业发展和领导经验，其中许多人 他们已转向独立的 NIH 和 VA 资助。我们持续的使命是建立和传播 优化对因酒精造成医疗伤害的艾滋病毒 (PAH) 老年患者的护理所需的证据 通过良好协调和完全整合的观察和干预研究。可以进入国家 EHR 数据包括药物填充/补充数据，我们具有独特的优势来研究与药物相关的危害 同时使用酒精和多种药物（多重用药）。为了服务于我们更大的使命，我们 计划 项目申请支持创建艾滋病毒和酒精研究中心，重点关注 多重用药 (HARP)，用于解决与有害酒精使用和多重用药相关的风险（AP 风险）。这 ADA 核心分为管理和数据分析部分，由经验丰富的研究人员组成 数据管理、高性能计算方面的协调员和扩大的专家组， 生物统计学和人工智能。该核心将解决清理和分析大型数据的挑战 规模、纵向 EHR 数据与其他数据源（例如调查、生物标志物和遗传学）相结合，以 支持观察性和试点干预研究。通过促进和告知数据访问、分析方法， 并与我们更大的网络保持良好的通信线路，ADA 核心将增强 HARP 的重要性和影响，提供项目资助时无法获得的经验和资源 分别地。凭借我们的经验、资源和动力，ADA 核心具有独特的优势来解决 PAH 中的 AP 风险。