Overture: A Multi-Scale Data Platform for Cancer Genomics Research

Overture：癌症基因组学研究的多尺度数据平台

• 批准号: 10305416
• 负责人: LINCOLN D. STEIN
• 金额: $ 53.46万
• 依托单位: ONTARIO INSTITUTE FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-09 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10305416
• 关键词: Adoption; Authorization documentation; Biological Markers; Canada; Cancer Model; Clinical; Collection; Communities; Computer software; Consent; Data; Data Discovery; Data Management Resources; Data Scientist; Data Set; Dependence; Development; Documentation; Educational workshop; European; Event; FAIR principles; Feedback; Focus Groups; Generations; Genomic Data Commons; Genomics; Goals; Grant; Health; Human; Individual; Informatics; International; Internet; Laboratories; Life Cycle Stages; Malignant Neoplasms; Medical Imaging; Metadata; NCI Center for Cancer Research; Oncology; Ontology; Pathway interactions; Patients; Plug-in; Protocols documentation; Research; Research Personnel; Resources; Sample Size; Software Engineering; Software Framework; Standardization; System; Testing; Time; Training; Validation; Visualization; Visualization software; big data management; cancer genome; cancer genomics; cloud based; cohort; community engagement; cost effective; data access; data exchange; data integration; data management; data portal; data resource; data sharing; design; genome-wide; genomic data; health data; improved; informatics tool; innovation; interest; large datasets; large scale data; multiscale data; novel; open source; outreach; rare cancer; symposium; tool; transmission process; user-friendly; web portal; webinar

Project Summary/Abstract Overture is a collection of modular, open-source software components designed to make the management of big-data genomic projects both easy and more cost effective. The Overture system promotes FAIR data sharing of cancer genomic datasets by overcoming the major obstacles in storing, managing, exploring, and distributing massive genome-scale datasets. In this proposed project, we will implement a turnkey Overture Data Management System (DMS) to provide a complete solution to manage cancer genomic data throughout the data life cycle, and to continue lowering the technical barriers faced by researchers in the cancer informatics community. To extend the capabilities and potential of the Overture DMS, we will establish a new software framework for integration with third-party visualization applications, and for data exchange with analysis platforms. This framework will empower the community to continue developing extremely valuable visualization applications for specific research interests and datatypes, and to contribute them as “apps” to be integrated with the Overture DMS. Over the next five years, we will: (1) combine the core set of Overture components into a scalable DMS installation bundle to promote both local and cloud deployment for a range of small to consortia-scale datasets; (2) extend the DMS with third-party visualization and analysis tools through a novel software data integration framework; (3) enhance data access controls by implementing Global Alliance for Genomics and Health (GA4GH) Passport and Data Use Ontology standards; (3) enable federated searching within cancer datasets across different Overture platforms; and (4) improve outreach and community resources to meet the needs of bioinformaticians, data producers and managers, data scientists, and clinical researchers. The Overture DMS will be a valuable resource for removing complications of large-scale data management from researchers, allowing the advancement of scientific research by increasing data sharing and discovery.

项目总结/摘要 Overture是一个模块化的开源软件组件的集合，旨在管理 大数据基因组项目既简单又更具成本效益。Overture系统促进FAIR数据 通过克服存储、管理、探索和分析方面的主要障碍， 分发大量基因组规模的数据集。 在这项拟议工程计划中，我们会实施一套交钥匙工程数据管理系统， 完整的解决方案，在整个数据生命周期内管理癌症基因组数据，并继续降低 癌症信息学社区研究人员面临的技术障碍。为了扩展能力， 为了充分发挥Overture DMS的潜力，我们将建立一个新的软件框架，以便与第三方集成 可视化应用程序，并与分析平台进行数据交换。这一框架将使 社区继续为特定的研究兴趣开发极具价值的可视化应用程序 和数据库，并将它们作为“应用程序”与Overture DMS集成。 在接下来的五年里，我们将：（1）将Overture的核心组件组合成可扩展的DMS 安装捆绑包，以促进一系列小型到联盟规模数据集的本地和云部署; (2)通过新颖的软件数据集成，使用第三方可视化和分析工具扩展DMS （3）通过实施全球基因组学与健康联盟加强数据访问控制 （GA 4GH）通行证和数据使用本体标准;（3）在癌症数据集中启用联合搜索 （4）改善外展和社区资源，以满足 生物信息学家、数据生产者和管理者、数据科学家和临床研究人员。序曲DMS 将是一个宝贵的资源，消除复杂的大规模数据管理的研究人员， 通过增加数据共享和发现来促进科学研究。