Reactome: An Open Knowledgebase of Human Pathways

Reactome：人类通路的开放知识库

• 批准号: 7390413
• 负责人: LINCOLN D. STEIN
• 金额: $ 96.6万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390413
• 关键词: Animal Model; Communities; Computer software; Data; Data Set; Data Sources; Databases; Gene Expression; Human; Human Genome; Internet; Lead; Molecular; Pathway interactions; Peer Review; Phase; Procedures; Proteins; Reaction; Research; Site; Standards of Weights and Measures; data modeling; design; outreach; software systems; tool; user-friendly

DESCRIPTION (provided by applicant): Accurate and complete human pathway information is crucial for the successful exploitation of the human genome in a variety of experimental contexts. The Reactome project has enjoyed a successful pilot phase to develop appropriate data models and tools for storing pathway information. In the pilot we have used these tools to curate to the highest level of accuracy pathways involving 1,200 non redundant proteins, which compares favourably to other pathway databases. In this proposal we aim to populate Reactome with pathways which comprise 5,000 non redundant human proteins and extend Reactome to incorporate an additional 10,000 proteins. Consistent with the pilot, all of Reactome's data and software will be made freely available.

描述（由申请人提供）：准确而完整的人类途径信息对于在各种实验环境中成功剥削人类基因组至关重要。 Reactome项目享有成功的试点阶段，以开发适当的数据模型和用于存储途径信息的工具。在飞行员中，我们使用这些工具将涉及1200个非冗余蛋白的最高准确途径策划，这与其他途径数据库相比有利。在此提案中，我们旨在用构成5,000个非冗余人蛋白的途径填充反应组，并扩展反应组，以掺入另外10,000种蛋白质。与飞行员一致，Reactome的所有数据和软件都将免费提供。