Reactome: An Open Knowledgebase of Human Pathways

描述(由申请人提供)：准确和完整的人类途径信息对于在各种实验环境中成功开发人类基因组至关重要。Reactome项目已经成功地进行了试验阶段，以开发适当的数据模型和工具来存储路径信息。在试点中，我们使用这些工具来精选涉及1,200个非冗余蛋白质的最高水平的准确性途径，这比其他途径数据库更好。在这项提案中，我们的目标是用包含5,000个非冗余人类蛋白质的通路来填充Reactome，并将Reactome扩展到包含另外10,000个蛋白质。与试点项目一致，Reactome的所有数据和软件都将免费提供。

DESCRIPTION (provided by applicant): Accurate and complete human pathway information is crucial for the successful exploitation of the human genome in a variety of experimental contexts. The Reactome project has enjoyed a successful pilot phase to develop appropriate data models and tools for storing pathway information. In the pilot we have used these tools to curate to the highest level of accuracy pathways involving 1,200 non redundant proteins, which compares favourably to other pathway databases. In this proposal we aim to populate Reactome with pathways which comprise 5,000 non redundant human proteins and extend Reactome to incorporate an additional 10,000 proteins. Consistent with the pilot, all of Reactome's data and software will be made freely available.