Reactome: An Open Knowledgebase of Human Pathways

描述（由申请人提供）：准确和完整的人类通路信息对于在各种实验环境中成功利用人类基因组至关重要。Reactome项目在开发用于存储路径信息的适当数据模型和工具方面取得了成功。在试点中，我们已经使用这些工具来策划涉及1200个非冗余蛋白质的最高准确性途径，这与其他途径数据库相比是有利的。在本提案中，我们的目标是用包含5,000个非冗余人类蛋白质的途径填充Reactome，并扩展Reactome以包含额外的10,000个蛋白质。与试点项目一致，Reactome的所有数据和软件都将免费提供。

DESCRIPTION (provided by applicant): Accurate and complete human pathway information is crucial for the successful exploitation of the human genome in a variety of experimental contexts. The Reactome project has enjoyed a successful pilot phase to develop appropriate data models and tools for storing pathway information. In the pilot we have used these tools to curate to the highest level of accuracy pathways involving 1,200 non redundant proteins, which compares favourably to other pathway databases. In this proposal we aim to populate Reactome with pathways which comprise 5,000 non redundant human proteins and extend Reactome to incorporate an additional 10,000 proteins. Consistent with the pilot, all of Reactome's data and software will be made freely available.