Reactome: An Open Knowledgebase of Human Pathways

Reactome：人类通路的开放知识库

• 批准号: 7866625
• 负责人: LINCOLN D. STEIN
• 金额: $ 85.85万
• 依托单位: ONTARIO INSTITUTE FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7866625
• 关键词: Reactome; Open; Knowledgebase; Human; Pathways

DESCRIPTION (provided by applicant): Accurate and complete human pathway information is crucial for the successful exploitation of the human genome in a variety of experimental contexts. The Reactome project has enjoyed a successful pilot phase to develop appropriate data models and tools for storing pathway information. In the pilot we have used these tools to curate to the highest level of accuracy pathways involving 1,200 non redundant proteins, which compares favourably to other pathway databases. In this proposal we aim to populate Reactome with pathways which comprise 5,000 non redundant human proteins and extend Reactome to incorporate an additional 10,000 proteins. Consistent with the pilot, all of Reactome's data and software will be made freely available.

描述（由申请人提供）：准确和完整的人类途径信息对于在各种实验环境中成功利用人类基因组至关重要。Reactome项目在开发适当的数据模型和储存途径信息的工具方面经历了一个成功的试验阶段。在试点中，我们使用这些工具来管理涉及1，200个非冗余蛋白质的最高水平的准确性途径，这与其他途径数据库相比是有利的。在这项提案中，我们的目标是用包含5,000种非冗余人类蛋白质的途径填充Reactome，并将Reactome扩展到另外10,000种蛋白质。与试点一致，Reactome的所有数据和软件都将免费提供。