INTERGENERATIONAL TRANSMISSION OF DEFICITS IN SELF-REGULATORY CONTROL

自我调节缺陷在各种儿童精神疾病中很常见， 孩子们很难控制他们的思想，情绪和行为。通过利用 以前收集的产前和新生儿数据，并从母婴中获取新数据 二联体，这项研究将确定基于电路的标志物的调节缺陷，通过间， 从婴儿期到儿童期持续存在。我们将招募15-45岁的孕妇 妇女/母亲，大约75%是拉丁裔，她们正在接受我们城市的医疗保健， 医学中心，一个在美国生物医学研究中代表性不足的样本， 严重的心理社会逆境监管控制过程的适当措施 将从4个月和14个月大的后代以及学龄前和学龄期获得， 包括来自新生儿的静息状态fMRI数据，以及来自 以前作为新生儿扫描的学龄儿童。行为测量 调节能力以及静息和基于任务的功能磁共振成像也将从母亲那里获得， 使我们能够将母亲和新生儿的自我调节控制指数联系起来。因此，本研究 将揭示从婴儿到学龄的控制过程和电路的轨迹， 调节缺陷从母亲到后代的代际传递。调查结果将 未来研究的阶段旨在将这些电路作为策略的目标， 预防未来适应不良行为的风险，并确定产前机制 作为监管缺陷代际传递的基础，如表观遗传和 压力介导的生物学改变。本研究支持NIMH的战略目标 绘制精神疾病的轨迹，以确定何时，何地以及如何进行干预， 阐明了在生命的第一个十年中调节控制的发展。本研究还 通过评估功能，支持NIH BRAIN和精准医学计划。 跨家族世代和纵向的控制电路的组织，以及使用 新的成像方法来预测行为结果。

Self-regulatory deficits are common across a variety of childhood psychiatric disorders in which children have difficulty regulating their thoughts, emotions, and behaviors. By leveraging previously collected prenatal and neonatal data and acquiring new data from mother-infant dyads, this study will identify circuit-based markers of regulatory deficits that are passed inter- generationally and persist from infancy to childhood. We will enroll 15-45 year-old pregnant women/mothers, approximately 75% Latina, who are receiving health care from our urban medical center, a sample that is underrepresented in U.S. biomedical research and facing significant psychosocial adversity. Age-appropriate measures of regulatory control processes will be acquired from their offspring at 4- and 14-months and during preschool and school age, including resting-state fMRI data from neonates and both resting and task-based fMRI data from school-aged children who were previously scanned as neonates. Behavioral measures of regulatory capacity and resting and task-based fMRI will also be acquired from the mothers, allowing us to associate maternal-neonatal indices of self-regulatory control. Thus, this study will uncover trajectories of control processes and circuits from infancy to school age and the intergenerational transmission of regulatory deficits from mothers to offspring. Findings will set the stage for future research aimed at engaging these circuits as targets for strategies to prevent the risk for future maladaptive behaviors and at identifying prenatal mechanisms underlying the intergenerational transmission of regulatory deficits, such as epigenetic and stress-mediated biological alterations. This study supports the NIMH strategic objective to chart mental illness trajectories to determine when, where, and how to intervene by elucidating the development of regulatory control across the first decade of life. This study also supports both the NIH BRAIN and precision medicine initiatives by evaluating the functional organization of control circuits across family generations and longitudinally, as well as using a novel imaging method to predict behavioral outcomes.