Intergenerational Transmission of Deficits In Self-Regulatory Control

项目摘要 自我调节缺陷在各种儿童精神疾病中很常见， 难以控制他们的思想、情绪和行为。通过利用以前收集的产前和 新生儿数据和获得新的数据，从母婴二对，这项研究将确定电路为基础的标志物， 调节缺陷是通过代际，并持续从婴儿到儿童。我们将招收15- 45岁的孕妇/母亲，大约75%是拉丁裔，他们正在接受我们的医疗保健， 禁止医疗中心，一个样本，是在美国生物医学研究代表性不足，并面临重大心理- 社会逆境适当的监管控制过程措施将从其外部获得， 在4个月和14个月的春天，在学龄前和学龄前，包括休息状态的功能磁共振成像数据，从新， nates和来自学龄儿童的静息和基于任务的fMRI数据，这些儿童以前被扫描为 新生儿还将获得调节能力的行为测量以及基于静息和任务的功能磁共振成像 从母亲那里，让我们把母亲和新生儿的自我调节控制指数联系起来。因此，本研究 将揭示从婴儿期到学龄期和代际之间的控制过程和电路的轨迹 调节缺陷从母亲传给后代。研究结果将为未来的研究奠定基础 旨在将这些回路作为预防未来适应不良行为风险的策略的目标 并在确定产前机制的基础上代际传递的监管缺陷， 例如表观遗传和压力介导的生物学改变。本研究支持NIMH的战略目标 绘制精神疾病的轨迹，以确定何时，何地，以及如何通过阐明发展进行干预- 在生命的第一个十年里，监管控制的作用。这项研究也支持NIH大脑和前 通过评估跨家庭世代控制回路的功能组织， 以及使用一种新的成像方法来预测行为结果。

PROJECT SUMMARY Self-regulatory deficits are common across a variety of childhood psychiatric disorders in which children have difficulty regulating their thoughts, emotions, and behaviors. By leveraging previously collected prenatal and neonatal data and acquiring new data from mother-infant dyads, this study will identify circuit-based markers of regulatory deficits that are passed inter-generationally, and persist from infancy to childhood. We will enroll 15- 45 year-old pregnant women/mothers, approximately 75% Latina, who are receiving health care from our ur- ban medical center, a sample that is underrepresented in U.S. biomedical research and facing significant psy- chosocial adversity. Age-appropriate measures of regulatory control processes will be acquired from their off- spring at 4- and 14-months and during preschool and school age, including resting-state fMRI data from neo- nates and both resting and task-based fMRI data from school-aged children who were previously scanned as neonates. Behavioral measures of regulatory capacity and resting and task-based fMRI will also be acquired from the mothers, allowing us to associate maternal-neonatal indices of self-regulatory control. Thus, this study will uncover trajectories of control processes and circuits from infancy to school age and the intergenerational transmission of regulatory deficits from mothers to offspring. Findings will set the stage for future research aimed at engaging these circuits as targets for strategies to prevent the risk for future maladaptive behaviors and at identifying prenatal mechanisms underlying the intergenerational transmission of regulatory deficits, such as epigenetic and stress-mediated biological alterations. This study supports the NIMH strategic objective to chart mental illness trajectories to determine when, where, and how to intervene by elucidating the develop- ment of regulatory control across the first decade of life. This study also supports both the NIH BRAIN and pre- cision medicine initiatives by evaluating the functional organization of control circuits across family generations and longitudinally, as well as using a novel imaging method to predict behavioral outcomes.