Intergenerational Transmission of Deficits In Self-Regulatory Control

自律控制缺陷的代际传递

• 批准号: 9975218
• 负责人: RACHEL MARSH
• 金额: $ 69.53万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975218
• 关键词: Adult; Age; Age-Months; Behavior; Behavioral; Biological; Biomedical Research; Birth; Brain; Child; Childhood; Cognitive; Conduct Disorder; Conflict (Psychology); Corpus striatum structure; Data; Development; Emotional; Emotions; Enrollment; Epigenetic Process; Family; Functional Magnetic Resonance Imaging; Future; Generations; Healthcare; Individual Differences; Infant; Intervention; Latina; Life; MRI Scans; Magnetic Resonance Imaging; Measures; Mediating; Medical center; Mental disorders; Methods; Mothers; National Institute of Mental Health; Neonatal; Nursery Schools; Outcome; Parietal; Partner in relationship; Patient Self-Report; Pattern; Performance; Population; Populations at Risk; Precision Medicine Initiative; Pregnancy; Pregnant Women; Prevention strategy; Process; Process Measure; Reporting; Research Domain Criteria; Resources; Rest; Risk; Sampling; Scanning; School-Age Population; Stress; Student Dropouts; Study models; Teenagers; Thinking; Third Pregnancy Trimester; United States National Institutes of Health; Woman; Youth; base; behavior measurement; behavioral outcome; brain behavior; follow-up; high risk; imaging modality; indexing; infancy; intergenerational; multimodality; neonatal brain; neonatal period; neonate; novel; offspring; personalized predictions; postnatal; predictive modeling; pregnant teen; prenatal; prevent; psychosocial; recruit; teration; transmission process

PROJECT SUMMARY Self-regulatory deficits are common across a variety of childhood psychiatric disorders in which children have difficulty regulating their thoughts, emotions, and behaviors. By leveraging previously collected prenatal and neonatal data and acquiring new data from mother-infant dyads, this study will identify circuit-based markers of regulatory deficits that are passed inter-generationally, and persist from infancy to childhood. We will enroll 15- 45 year-old pregnant women/mothers, approximately 75% Latina, who are receiving health care from our ur- ban medical center, a sample that is underrepresented in U.S. biomedical research and facing significant psy- chosocial adversity. Age-appropriate measures of regulatory control processes will be acquired from their off- spring at 4- and 14-months and during preschool and school age, including resting-state fMRI data from neo- nates and both resting and task-based fMRI data from school-aged children who were previously scanned as neonates. Behavioral measures of regulatory capacity and resting and task-based fMRI will also be acquired from the mothers, allowing us to associate maternal-neonatal indices of self-regulatory control. Thus, this study will uncover trajectories of control processes and circuits from infancy to school age and the intergenerational transmission of regulatory deficits from mothers to offspring. Findings will set the stage for future research aimed at engaging these circuits as targets for strategies to prevent the risk for future maladaptive behaviors and at identifying prenatal mechanisms underlying the intergenerational transmission of regulatory deficits, such as epigenetic and stress-mediated biological alterations. This study supports the NIMH strategic objective to chart mental illness trajectories to determine when, where, and how to intervene by elucidating the develop- ment of regulatory control across the first decade of life. This study also supports both the NIH BRAIN and pre- cision medicine initiatives by evaluating the functional organization of control circuits across family generations and longitudinally, as well as using a novel imaging method to predict behavioral outcomes.

项目总结 自我调节缺陷在各种儿童精神障碍中很常见，其中儿童有 难以控制他们的思想、情绪和行为。通过利用之前收集的产前和 新生儿数据和从母婴二联体中获取新数据，这项研究将识别基于电路的标记 代代相传的监管缺陷，从婴儿期一直持续到童年。我们将招收15名- 45岁的孕妇/母亲，大约75%是拉丁裔，她们正在接受我们- BAN医疗中心，一个在美国生物医学研究中代表性不足的样本，面临着重大的心理疾病- 选择的社会逆境。监管控制过程的适龄措施将从他们的非- 在4个月和14个月大的时候以及在学龄前和学龄期，包括来自neo-a的静息状态的fMRI数据。 NATS以及来自学龄儿童的休息和基于任务的fMRI数据，这些学龄儿童之前被扫描为 新生儿。还将获得调节能力和休息以及基于任务的功能磁共振成像的行为测量 来自母亲的数据，使我们能够将母亲和新生儿的自我调节控制指数联系起来。因此，这项研究 将揭示从婴儿期到学龄期的控制过程和回路的轨迹以及代际 将监管缺陷从母亲传递给后代。这些发现将为未来的研究奠定基础 旨在将这些回路作为预防未来适应不良行为风险的战略目标 并在确定监管缺陷代际传递的产前机制方面， 例如表观遗传和压力介导的生物变化。这项研究支持NIMH的战略目标 为了绘制精神疾病的轨迹图，以确定何时、何地以及如何干预，通过阐明发展- 在生命的第一个十年里，监管控制的重要性。这项研究也支持NIH的大脑和Pre-Pre 通过评估家族世代间控制回路的功能组织来实现精准医学计划 并使用一种新的成像方法来预测行为结果。