Identifying the role of short-term fine particulate matter air pollution in the heart and lung health outcomes of adolescent and young adult cancer survivors

确定短期细颗粒物空气污染对青少年和年轻成年癌症幸存者的心脏和肺部健康结果的作用

基本信息

  • 批准号:
    10308109
  • 负责人:
  • 金额:
    $ 7.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-12-01 至 2022-11-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY ABSTRACT Cardiovascular (CV) and respiratory toxicity from cancer treatments are a major causes of morbidity among adolescent and young adult (AYA) cancer survivors. This toxicity may reduce a survivor’s ability to neutralize the added physiologic stress from short-term air pollution exposure, leading to a higher risk for cardiovascular and respiratory problems. However, the health effects of exposure to air pollution on AYA cancer survivors are largely unknown. To fill this knowledge gap, we will examine how fine particulate matter (PM2.5) is associated with CV and respiratory health events among survivors diagnosed with the five most common AYA cancers in the state of Utah (thyroid, melanoma, breast, lymphoma, testicular) between 1997 and 2016 (N=9,382). We will employ a case-crossover design nested in this preexisting cohort to examine the effects of short-term PM2.5 on the risk for cardiovascular and respiratory health events defined from statewide hospital discharge and emergency department data, and outpatient records from Utah’s two largest health systems serving >85% of Utah. Using data from the Utah Population Database, we can measure residential PM2.5 exposure at the address level for our sample. We will: 1) Investigate the association between short-term PM2.5 and CV and respiratory health events among AYA cancer survivors, and compare survivors’ risk of PM2.5-associated health events to a cancer-free sample, and 2) Determine whether treatments with known toxicities modify the association between short-term PM2.5 and CV and respiratory health events among AYA cancer survivors. We will identify temporal trends in these associations among survivors from diagnosis to the end of follow-up. Subgroups of survivors will be investigated to determine differences by smoking, race/ethnicity, and other relevant factors. Utah has severe PM2.5 pollution due to winter inversions and summer wildfires. Because of the pervasiveness of air pollution in United States and the lack of data on how environmental pollutants affect cancer survivors, this project represents a unique opportunity to determine whether air pollution is a risk factor for cardiovascular and respiratory health problems among AYA cancer survivors. Our study will provide a deep examination of cancer treatment, health care utilization, and PM2.5 exposure, and expand upon the established perspective of survivorship research by adding information the role air pollution on the risk for health events among cancer survivors.
项目摘要

项目成果

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Anne C Kirchhoff其他文献

Anne C Kirchhoff的其他文献

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{{ truncateString('Anne C Kirchhoff', 18)}}的其他基金

A Randomized Controlled Trial to Improve Health Insurance Literacy and Surveillance among Young Adult Cancer Survivors
提高年轻成年癌症幸存者的健康保险知识和监测的随机对照试验
  • 批准号:
    10660663
  • 财政年份:
    2023
  • 资助金额:
    $ 7.63万
  • 项目类别:
Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden: A CCSS randomized trial
评估虚拟导航干预措施对提高健康保险知识和减轻经济负担的效果:一项 CCSS 随机试验
  • 批准号:
    10632063
  • 财政年份:
    2022
  • 资助金额:
    $ 7.63万
  • 项目类别:
Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden: A CCSS randomized trial
评估虚拟导航干预措施对提高健康保险知识和减轻经济负担的效果:一项 CCSS 随机试验
  • 批准号:
    10458154
  • 财政年份:
    2022
  • 资助金额:
    $ 7.63万
  • 项目类别:
Improving Health Insurance Experiences for Adolescent and Young Adult Cancer Patients
改善青少年癌症患者的健康保险体验
  • 批准号:
    10204974
  • 财政年份:
    2019
  • 资助金额:
    $ 7.63万
  • 项目类别:
Improving Health Insurance Experiences for Adolescent and Young Adult Cancer Patients
改善青少年癌症患者的健康保险体验
  • 批准号:
    9978750
  • 财政年份:
    2019
  • 资助金额:
    $ 7.63万
  • 项目类别:
Health and socioeconomic outcomes for adolescent and young adult cancer survivors
青少年和年轻成人癌症幸存者的健康和社会经济成果
  • 批准号:
    8490832
  • 财政年份:
    2013
  • 资助金额:
    $ 7.63万
  • 项目类别:
Health and socioeconomic outcomes for adolescent and young adult cancer survivors
青少年和年轻成人癌症幸存者的健康和社会经济成果
  • 批准号:
    8638908
  • 财政年份:
    2013
  • 资助金额:
    $ 7.63万
  • 项目类别:

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