Health and socioeconomic outcomes for adolescent and young adult cancer survivors

青少年和年轻成人癌症幸存者的健康和社会经济成果

• 批准号: 8638908
• 负责人: Anne C Kirchhoff
• 金额: $ 7.23万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8638908
• 关键词: Adherence; Adolescence; Adolescent and Young Adult; Affect; Age; Arthritis; Asthma; Behavioral Risk Factor Surveillance System; Cancer Control; Cancer Patient; Cancer Survivor; Cancer Survivorship; Child; Cholesterol; Clinic; Comorbidity; Complex; Conflict (Psychology); Control Groups; Coronary Arteriosclerosis; Coupled; Data; Data Set; Development; Diabetes Mellitus; Diagnosis; Diagnostic Neoplasm Staging; Education; Employment; Ethnic Origin; Evaluation; Goals; Grant; Health; Health Services Accessibility; Health behavior; Hypertension; Individual; Insurance; Intervention; Interview; Lead; Life Style; Longevity; Malignant Neoplasms; Methods; Minority; Minority Groups; Modeling; Myocardial Infarction; Obesity; Outcome; Overweight; Parents; Physical activity; Population; Quality of life; Race; Reporting; Research; Risk; Sampling; Schools; Smoking; Stroke; Surveys; Survivors; Time; Tobacco use; Treatment Protocols; Uninsured; United States; Work; age group; aged; alcohol misuse; base; binge drinking; cancer diagnosis; cancer prevention; cancer therapy; career; comparison group; design; experience; follow-up; high risk; improved; innovation; interest; intervention program; meetings; neoplasm registry; population based; programs; psychosocial development; public health relevance; response; sex; socioeconomics; survivorship; young adult

DESCRIPTION (provided by applicant): Our study targets a significantly understudied research question in adolescent and young adult (AYA) cancer survivorship: How does a cancer diagnosis during adolescence and young adulthood affect survivors' quality of life? Due to the unique developmental transitions that occur for AYAs, such as completing education, starting careers, and gaining financial independence, a cancer diagnosis may cause particular burden for this age group. Guided by a conceptual model of cancer survivor quality of life, we will use the 2009 Behavioral Risk Factor Surveillance System (BRFSS) data to evaluate quality of life for survivors of AYA cancer in response to this PAR 12-035's identification of large, national datasets for assessing cancer prevention and control outcomes. In Specific Aim 1, we will evaluate the quality of life of survivors of AYA cancer (diagnosed ages 15- 39) compared to similarly-aged individuals without cancer. In Specific Aim 2, we will investigate whether survivors of AYA cancer are at higher risk for comorbid conditions, poor health behavior, and educational and employment limitations compared to similarly-aged individuals without cancer. We identified these outcomes (referred to as "Survivorship Factors") as fundamentally important to quality of life due to the unique developmental circumstances of AYAs. Following these analyses, in Specific Aim 3, we will determine whether quality of life is associated with the Survivorship Factors of interest, to provide information on the factors that most influence poor quality of life among AYA survivors. For all aims, we will examine our outcomes by age at diagnosis (e.g., 15-20, 21-29, 30-39), current age (e.g., 18-29; 30-39; 40-49; 50-64; e65) and sex to capture unique sub-group differences. We will determine whether survivors of minority race or ethnicity are at particular risk for poor quality of life. Our study is the first to estimate the nation-wide impactof cancer on AYA survivor quality of life with a control group comparison. To date, the majority of studies on AYA survivors have been limited to specific cancer diagnoses and to samples drawn from a limited number of cancer registries or clinics that do not include a comparison group. Following this R03 study, our team will apply for an R21 grant to support a subsequent mixed methods study. We will perform qualitative interviews to inform a survey to launch a comprehensive evaluation of AYA cancer survivor quality of life that considers important differences in cancer stage and treatment intensity. This R03 is a fundamental step towards meeting our long-term goal of creating interventions tailored to the unique comorbidity, health behavior, educational and employment needs of AYA survivors to improve their quality of life.

描述（由申请人提供）：我们的研究针对青少年和青年（AYA）癌症生存率中一个研究不足的研究问题：青少年和青年期的癌症诊断如何影响幸存者的生活质量？由于AYA发生的独特发展转变，例如完成教育，开始职业生涯和获得经济独立，癌症诊断可能会对这个年龄组造成特别的负担。在癌症幸存者生活质量概念模型的指导下，我们将使用2009年行为风险因素监测系统（BRFSS）数据来评估AYA癌症幸存者的生活质量，以响应PAR 12-035对评估癌症预防和控制结果的大型国家数据集的识别。在具体目标1中，我们将评估AYA癌症幸存者（诊断年龄为15- 39岁）与同龄无癌症个体的生活质量。在《特定目标2》中，我们将调查幸存者是否 与年龄相仿的非癌症患者相比，AYA癌症患者的共病状况、不良健康行为以及教育和就业限制的风险更高。由于AYA独特的发育环境，我们确定这些结果（称为“生存因素”）对生活质量至关重要。在这些分析之后，在具体目标3中，我们将确定生活质量是否与感兴趣的生存因素相关，以提供最影响生活质量差的因素的信息 AYA幸存者中。对于所有目标，我们将按诊断时的年龄检查我们的结果（例如，15-20，21-29，30-39），当前年龄（例如，18-29; 30-39; 40-49; 50-64; e65）和性别，以获取独特的亚组差异。我们将确定少数种族或族裔的幸存者是否特别有生活质量差的风险。我们的研究是第一个评估全国范围内癌症对AYA幸存者生活质量的影响，并与对照组进行比较。迄今为止，大多数关于AYA幸存者的研究仅限于特定的癌症诊断，以及从数量有限的癌症登记处或诊所中抽取的样本，这些样本不包括对照组。在这项R 03研究之后，我们的团队将申请R21资助，以支持随后的混合方法研究。我们将进行定性访谈，为调查提供信息，以全面评估AYA癌症幸存者的生活质量，考虑癌症阶段和治疗强度的重要差异。R 03是实现我们长期目标的基础一步，即根据AYA幸存者独特的comorphism，健康行为，教育和就业需求制定干预措施，以提高他们的生活质量。