Mechanisms of cochlear synaptopathy after noise or blast trauma

噪音或爆炸创伤后耳蜗突触病的机制

基本信息

  • 批准号:
    10307056
  • 负责人:
  • 金额:
    $ 57.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-01-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic hydrops correlated with cochlear synaptopathy. Our central hypothesis is that endolymphatic hydrops is a surrogate marker for swelling of auditory nerve dendrites that occurs in response to glutamate excitotoxicity. We will test this hypothesis with three aims. First, we will determine whether swelling of auditory nerve dendrites correlates with endolymphatic hydrops. We will measure the volume of scala media in vivo using volumetric optical coherence tomography and vibrometry (VOCTV). We will simultaneously image auditory nerve fiber terminals in vivo with two-photon microscopy and measure their diameter. Second, we will determine whether acute hair cell dysfunction is necessary to produce the physiological consequences of cochlear synaptopathy. We will measure basilar membrane vibratory tuning curves using VOCTV to assess cochlear physiology. We will also measure the wave 1 auditory brainstem response (ABR) peak-to-peak amplitude to assess auditory nerve physiology. Third, we will determine whether the inciting mechanism of cochlear synaptopathy is glutamate, endolymphatic hydrops, or dendritic swelling. We will measure scala media volume, cochlear gain, and synaptic counts after noise or hypotonic challenge in mice with impaired transduction or impaired glutamate release at the IHC-auditory nerve synapse. Therefore, we are proposing to definitively prove or disprove our hypothesis. Furthermore, we will understand the physiological consequences and mechanisms of endolymphatic hydrops and synaptopathy.
项目总结/文摘

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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John S Oghalai其他文献

John S Oghalai的其他文献

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{{ truncateString('John S Oghalai', 18)}}的其他基金

Otolaryngology Clinician-Scientist Training Program
耳鼻喉科临床医生科学家培训计划
  • 批准号:
    10649406
  • 财政年份:
    2022
  • 资助金额:
    $ 57.44万
  • 项目类别:
Otolaryngology Clinician-Scientist Training Program
耳鼻喉科临床医生科学家培训计划
  • 批准号:
    10291583
  • 财政年份:
    2022
  • 资助金额:
    $ 57.44万
  • 项目类别:
Mechanisms of cochlear synaptopathy after noise or blast trauma
噪音或爆炸创伤后耳蜗突触病的机制
  • 批准号:
    10053337
  • 财政年份:
    2020
  • 资助金额:
    $ 57.44万
  • 项目类别:
Mechanisms of cochlear synaptopathy after noise or blast trauma
噪声或爆炸损伤后耳蜗突触病的机制
  • 批准号:
    10540702
  • 财政年份:
    2020
  • 资助金额:
    $ 57.44万
  • 项目类别:
Mechanisms of cochlear synaptopathy after noise or blast trauma
噪声或爆炸损伤后耳蜗突触病的机制
  • 批准号:
    9887606
  • 财政年份:
    2020
  • 资助金额:
    $ 57.44万
  • 项目类别:
Conference on Implantable Auditory Prostheses
植入式听觉假体会议
  • 批准号:
    9892998
  • 财政年份:
    2017
  • 资助金额:
    $ 57.44万
  • 项目类别:
Optical coherence tomography for 3D measures of cochlear mechanics in vivo
用于体内耳蜗力学 3D 测量的光学相干断层扫描
  • 批准号:
    9454168
  • 财政年份:
    2015
  • 资助金额:
    $ 57.44万
  • 项目类别:
Cochlear mechanics in the mouse
小鼠的耳蜗力学
  • 批准号:
    10394238
  • 财政年份:
    2015
  • 资助金额:
    $ 57.44万
  • 项目类别:
Cochlear mechanics in the mouse
小鼠的耳蜗力学
  • 批准号:
    10614068
  • 财政年份:
    2015
  • 资助金额:
    $ 57.44万
  • 项目类别:
Cochlear mechanics in the mouse
小鼠的耳蜗力学
  • 批准号:
    8859866
  • 财政年份:
    2015
  • 资助金额:
    $ 57.44万
  • 项目类别:

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