Cochlear mechanics in the mouse
Cochlear mechanics in the mouse
批准号:
10394238
负责人:
John S Oghalai
金额:
$62.33万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
未结题
起止时间:
2015-05-01 至 2025-04-30
关键词:
3-DimensionalAffectAirAnatomyAnesthesia proceduresAnimalsArousalAuditoryAuditory systemBackBasic ScienceBasilar MembraneBiomechanicsBiomedical EngineeringBiophysical ProcessBrainCaliberCharacteristicsClinicalCochleaCochlear ductComplexDataDependenceEnvironmentExternal auditory canalFrequenciesHair CellsHeadHearingHearing AidsImageLeftMammalsMeasurementMeasuresMechanicsMedialMediatingMotionMusOptical Coherence TomographyOpticsOrgan of CortiOuter Hair CellsPainlessPhysiologyProcessProductionPupilReflex actionResearch Project GrantsResolutionRoleSpeechStructureSupporting CellSystemTechnologyTestingTimeTravelWalkingWild Type MouseWorkauditory stimulusawakebonecapsuledesignexperimental studyhearing impairmentin vivoindexinginnovationotoacoustic emissionpeerpressureresponsesoundstemtectorial membranetreadmillvectorvibrationwalking speed
中文摘要
项目摘要/摘要
声压通过哺乳动物的耳蜗区产生力量,最终产生一种振动
沿耳蜗管纵向传播的行波。区别这一过程的关键特征是
来自非哺乳动物耳蜗的是放大,由数千个外毛细胞产生的力
(OHC)锐化和放大行波。我们的首要目标是了解这个建筑群是如何
形成Corti器官的3D多细胞和无细胞排列的生物力学共同作用于
创建耳蜗放大功能。具体地说,我们将确定这一过程是如何产生的--
调谐的基底膜,创造了尖锐的频率调谐和高灵敏度。这个问题在一个
基础科学水平,因为这些生物物理过程是听到声音的能力的基础
空气中分子的布朗运动,具有精确的频率分辨率。这个问题还没有解决。
在临床上很重要,因为听力损失通常是由于耳蜗放大能力的丧失。我们的中央
假设是,除了基底膜力学提供的广泛调谐之外,由
OHC还可以通过其他机制进行调整。在目标1中,我们将使用3D体积光学相干
在小鼠身上进行断层扫描和振动测量(VOCTV),以测试OHC产生的力是否受到
构成Corti器官的支持细胞和无细胞结构的力学。在目标2中,我们将使用1D
VOCTV在清醒行为小鼠中测试耳蜗放大是否受到大脑状态的调节
不同OHC力产生的内侧橄榄耳蜗传出系统(MOC)。加在一起,这些数据将是
以此来验证我们的假设。如果我们的假设是真的,那么
Corti器官是哺乳动物耳蜗和大脑产生敏感度和敏锐调谐所必需的
状态通过MOC传出系统调节耳蜗放大。
英文摘要
Project Summary/Abstract
Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory
traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process
from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells
(OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex
biomechanics of the 3D multi-cellular and acellular arrangement that form the organ of Corti work together to
create cochlear amplification. Specifically, we will determine how this process, which stems from the broadly-
tuned basilar membrane, creates sharp frequency tuning and high sensitivity. This question is significant on a
basic science level because these biophysical processes underlie the ability to hear sounds just above the
Brownian motion of molecules in air with an exquisite frequency resolution. This question remains unsolved
and is clinically important because hearing loss is typically due to loss of cochlear amplification. Our central
hypothesis is that, beyond the broad tuning provided by basilar membrane mechanics, the forces produced by
OHCs are also tuned by additional mechanisms. In aim 1, we will use 3D Volumetric Optical Coherence
Tomography and Vibrometry (VOCTV) in mice to test whether the forces produced by OHCs are tuned by the
mechanics of the supporting cells and acellular structures that form the organ of Corti. In aim 2, we will use 1D
VOCTV in awake behaving mice to test whether cochlear amplification is modulated by brain state via the
medial olivocochlear efferent (MOC) system by varying OHC force production. Together, these data will be
interpreted so as to test our hypothesis. If our hypothesis is true, sharply-tuned differential motion within the
organ of Corti is necessary to generate the sensitivity and sharp tuning of the mammalian cochlea and brain
state modulates cochlear amplification via the MOC efferent system.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Otolaryngology Clinician-Scientist Training Program
-
批准号:10649406
-
项目类别:
-
资助金额:$31.89万
-
财政年份:2022
-
负责人:John S Oghalai
-
依托单位:
Otolaryngology Clinician-Scientist Training Program
-
批准号:10291583
-
项目类别:
-
资助金额:$17.56万
-
财政年份:2022
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10307056
-
项目类别:
-
资助金额:$57.44万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10053337
-
项目类别:
-
资助金额:$67.37万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10540702
-
项目类别:
-
资助金额:$57.44万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:9887606
-
项目类别:
-
资助金额:$71.05万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Conference on Implantable Auditory Prostheses
-
批准号:9892998
-
项目类别:
-
资助金额:$0.01万
-
财政年份:2017
-
负责人:John S Oghalai
-
依托单位:
Optical coherence tomography for 3D measures of cochlear mechanics in vivo
-
批准号:9454168
-
项目类别:
-
资助金额:$41.12万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Cochlear mechanics in the mouse
-
批准号:10614068
-
项目类别:
-
资助金额:$62.33万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Cochlear mechanics in the mouse
-
批准号:8859866
-
项目类别:
-
资助金额:$34.68万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Translation of near-infrared spectroscopy for use in clinical neuro-imaging
-
批准号:8083232
-
项目类别:
-
资助金额:$42.04万
-
财政年份:2010
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:7934579
-
项目类别:
-
资助金额:$43.83万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:7781837
-
项目类别:
-
资助金额:$45.71万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8317605
-
项目类别:
-
资助金额:$38.88万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8133443
-
项目类别:
-
资助金额:$39.96万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8512695
-
项目类别:
-
资助金额:$36.07万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7367077
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:6766496
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7018454
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7189014
-
项目类别:
-
资助金额:$16.9万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
海外基金