Cochlear mechanics in the mouse
Cochlear mechanics in the mouse
批准号:
10394238
负责人:
John S Oghalai
金额:
$62.33万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
未结题
起止时间:
2015-05-01 至 2025-04-30
关键词:
3-DimensionalAffectAirAnatomyAnesthesia proceduresAnimalsArousalAuditoryAuditory systemBackBasic ScienceBasilar MembraneBiomechanicsBiomedical EngineeringBiophysical ProcessBrainCaliberCharacteristicsClinicalCochleaCochlear ductComplexDataDependenceEnvironmentExternal auditory canalFrequenciesHair CellsHeadHearingHearing AidsImageLeftMammalsMeasurementMeasuresMechanicsMedialMediatingMotionMusOptical Coherence TomographyOpticsOrgan of CortiOuter Hair CellsPainlessPhysiologyProcessProductionPupilReflex actionResearch Project GrantsResolutionRoleSpeechStructureSupporting CellSystemTechnologyTestingTimeTravelWalkingWild Type MouseWorkauditory stimulusawakebonecapsuledesignexperimental studyhearing impairmentin vivoindexinginnovationotoacoustic emissionpeerpressureresponsesoundstemtectorial membranetreadmillvectorvibrationwalking speed
中文摘要
项目总结/摘要
声压在哺乳动物耳蜗分区产生力,最终产生振动
沿耳蜗管纵向传播的行波。这个过程的主要特点是
来自非哺乳动物耳蜗的是放大,
(OHC)锐化和放大行波。我们的首要目标是了解复杂的
形成Corti器官的3D多细胞和非细胞排列的生物力学共同作用,
产生耳蜗放大。具体来说,我们将确定这一过程,这源于广泛的-
调谐基底膜,创建尖锐的频率调谐和高灵敏度。这个问题在A
基础科学水平,因为这些生物物理过程的基础是听到声音的能力,
分子在空气中的布朗运动,具有精确的频率分辨率。这个问题仍然没有解决
并且在临床上是重要的,因为听力损失通常是由于耳蜗放大的损失。我们的中央
假设是,除了基底膜力学提供的广泛调谐之外,
OHC还通过其他机制进行调整。在目标1中,我们将使用3D体积光学相干
断层扫描和振动测量法(VOCTV)在小鼠中测试OHC产生的力是否由
支持细胞和形成Corti器官的非细胞结构的力学。在目标2中,我们将使用1D
在清醒行为小鼠中的VOCTV,以测试耳蜗放大是否通过
内侧橄榄耳蜗传出(MOC)系统通过不同的OHC力的产生。这些数据将被
来检验我们的假设。如果我们的假设是正确的,
Corti器官是产生哺乳动物耳蜗和大脑的灵敏度和敏锐调谐所必需的
状态通过MOC传出系统调节耳蜗放大。
英文摘要
Project Summary/Abstract
Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory
traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process
from the non-mammalian cochlea is amplification, whereby forces produced by thousands of outer hair cells
(OHCs) sharpen and amplify the traveling wave. Our overarching objective is to understand how the complex
biomechanics of the 3D multi-cellular and acellular arrangement that form the organ of Corti work together to
create cochlear amplification. Specifically, we will determine how this process, which stems from the broadly-
tuned basilar membrane, creates sharp frequency tuning and high sensitivity. This question is significant on a
basic science level because these biophysical processes underlie the ability to hear sounds just above the
Brownian motion of molecules in air with an exquisite frequency resolution. This question remains unsolved
and is clinically important because hearing loss is typically due to loss of cochlear amplification. Our central
hypothesis is that, beyond the broad tuning provided by basilar membrane mechanics, the forces produced by
OHCs are also tuned by additional mechanisms. In aim 1, we will use 3D Volumetric Optical Coherence
Tomography and Vibrometry (VOCTV) in mice to test whether the forces produced by OHCs are tuned by the
mechanics of the supporting cells and acellular structures that form the organ of Corti. In aim 2, we will use 1D
VOCTV in awake behaving mice to test whether cochlear amplification is modulated by brain state via the
medial olivocochlear efferent (MOC) system by varying OHC force production. Together, these data will be
interpreted so as to test our hypothesis. If our hypothesis is true, sharply-tuned differential motion within the
organ of Corti is necessary to generate the sensitivity and sharp tuning of the mammalian cochlea and brain
state modulates cochlear amplification via the MOC efferent system.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Otolaryngology Clinician-Scientist Training Program
-
批准号:10649406
-
项目类别:
-
资助金额:$31.89万
-
财政年份:2022
-
负责人:John S Oghalai
-
依托单位:
Otolaryngology Clinician-Scientist Training Program
-
批准号:10291583
-
项目类别:
-
资助金额:$17.56万
-
财政年份:2022
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10307056
-
项目类别:
-
资助金额:$57.44万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10053337
-
项目类别:
-
资助金额:$67.37万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:10540702
-
项目类别:
-
资助金额:$57.44万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Mechanisms of cochlear synaptopathy after noise or blast trauma
-
批准号:9887606
-
项目类别:
-
资助金额:$71.05万
-
财政年份:2020
-
负责人:John S Oghalai
-
依托单位:
Conference on Implantable Auditory Prostheses
-
批准号:9892998
-
项目类别:
-
资助金额:$0.01万
-
财政年份:2017
-
负责人:John S Oghalai
-
依托单位:
Optical coherence tomography for 3D measures of cochlear mechanics in vivo
-
批准号:9454168
-
项目类别:
-
资助金额:$41.12万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Cochlear mechanics in the mouse
-
批准号:10614068
-
项目类别:
-
资助金额:$62.33万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Cochlear mechanics in the mouse
-
批准号:8859866
-
项目类别:
-
资助金额:$34.68万
-
财政年份:2015
-
负责人:John S Oghalai
-
依托单位:
Translation of near-infrared spectroscopy for use in clinical neuro-imaging
-
批准号:8083232
-
项目类别:
-
资助金额:$42.04万
-
财政年份:2010
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:7934579
-
项目类别:
-
资助金额:$43.83万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:7781837
-
项目类别:
-
资助金额:$45.71万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8317605
-
项目类别:
-
资助金额:$38.88万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8133443
-
项目类别:
-
资助金额:$39.96万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
-
批准号:8512695
-
项目类别:
-
资助金额:$36.07万
-
财政年份:2009
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7367077
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:6766496
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7018454
-
项目类别:
-
资助金额:$16.74万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
Modulation of Cochlear Tuning
-
批准号:7189014
-
项目类别:
-
资助金额:$16.9万
-
财政年份:2004
-
负责人:John S Oghalai
-
依托单位:
海外基金