Identifying the causal role of the amygdala in human approach-avoidance conflict behavior

确定杏仁核在人类回避冲突行为中的因果作用

• 批准号: 10313619
• 负责人: Camarin Rolle
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2021-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10313619
• 关键词: Address; Affective; Amygdaloid structure; Animals; Attenuated; Automobile Driving; Behavior; Benchmarking; Bilateral; Blood; Bolus Infusion; Clinical; Conflict (Psychology); Coupling; Decision Making; Devices; Electroencephalogram; Electroencephalography; Electrophysiology (science); Epilepsy; Equilibrium; Etiology; Generalized Anxiety Disorder; Goals; Human; Individual; Intrinsic drive; Juice; Knowledge; Lead; Learning; Lesion; Major Depressive Disorder; Maps; Methods; Mission; Modeling; Mood Disorders; Occupational; Occupations; Oral; Outcome; Outcome Study; Output; Oxygen; Participant; Play; Post-Traumatic Stress Disorders; Prefrontal Cortex; Primates; Public Health; Punishment; Research; Resolution; Rewards; Role; Shock; Signal Transduction; Synaptic Membranes; Testing; United States National Institutes of Health; Wages; Work; Workload; approach avoidance behavior; approach behavior; avoidance behavior; behavior influence; cognitive neuroscience; density; disability; implantation; indexing; innovation; neuroimaging; neurotransmission; novel; novel strategies; operation; primary outcome; relating to nervous system; social; symptomatology; targeted biomarker; targeted treatment

Project Summary/Abstract. The decisions we make day-to-day are motivated by our intrinsic drives to approach rewarding, and avoid punishing, outcomes. These drives conflict in decisions with both rewarding and punishing outcomes (termed “approach-avoidance conflict”, AAC). Each individual’s balance of reward- and punishment- drives bias the approach or avoidance of a given AAC decision. Affective disorders are characterized by a disruption in this balance, causing greater avoidance in AAC decisions. Therefore, it is critically important to elucidate the neural substrates underlying reward- and punishment- drives, and how their disruption constitutes clinically imbalanced behavior. However, while neuroimaging work has corroborated a correlational relationship of the amygdala and prefrontal cortex to avoidant behavior in humans, no study has mapped the amygdala’s direct electrophysiological signals (i.e., non-BOLD) relevant to AAC behavior in humans, nor substantiated its causal influence on circuit dynamics and output behavior. The goal of the current work is to elucidate the amygdala’s causal role in approach- and avoidance-driven behavior, and the functional relevance of the prefrontal cortex to this relationship. The primary hypothesis is that the amygdala will actively drive avoidance through its connectivity with the prefrontal cortex. The hypothesis will be tested with three primary aims: 1) To map amygdala electrophysiology relevant to behavior during AAC using invasive amygdala recordings (iEEG) 2) To examine the causal role of the amygdala in AAC by inhibiting it using direct amygdala stimulation and 3) To elucidate the prefrontal cortical activation, in operation with the amygdala, as a function of AAC behavior by recording high-density cortical electroencephalogram (hdEEG) simultaneous to iEEG. AAC behavior will be quantified using a novel, validated task assessing approach-avoidance conflict drives. All electrophysiological recordings and stimulation will be delivered during the task. Amygdala signal will be primarily quantified as the high gamma power signal recorded with iEEG. Prefrontal cortical signal will be primarily quantified as the theta-band power recorded with hdEEG. Connectivity between the amygdala and prefrontal cortex will be quantified through theta-gamma coupling metrics. This proposal is innovative as it leverages the integration of cutting-edge cognitive neuroscience methods to characterize the neural signal driving avoidance behavior in humans. Regardless of the outcomes, the study will generate new questions in the field, and provide a rigorous benchmark against which to hold further work in the field. Findings from the proposed work will provide critical information to the field regarding the neural features driving avoidance symptomatology in affective disorders.

项目总结/抽象。