Using Resting State Functional MRI to Predict Cognitive Decline among World Trade Center Responders

使用静息态功能 MRI 预测世贸中心急救人员的认知能力下降

• 批准号: 10315069
• 负责人: Sara L. Weisenbach
• 金额: $ 24.98万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10315069
• 关键词: Age; Alzheimer' s Disease; Atrophic; Biological Markers; Brain; Caring; Cause of Death; Cessation of life; Chronic; Cognition; Cognitive; Communities; Cost of Illness; Coupling; Data; Dementia; Diagnostic; Dorsal; Early identification; Etiology; Functional Magnetic Resonance Imaging; Future; Goals; Health; Hippocampus (Brain); Impaired cognition; Major Depressive Disorder; Measures; Memory; Mental Depression; Modeling; Monitor; Nerve Degeneration; Neurophysiology - biologic function; Participant; Pattern; Performance; Plasma; Population; Post-Traumatic Stress Disorders; Prefrontal Cortex; Prevention; Process; Reporting; Research; Rest; Sampling; Scanning; Severities; Source; Structure; Suggestion; Surveillance Program; Survivors; Symptoms; Temporal Lobe; Thick; Time; Trauma; Visit; Wellness Program; World Health; cingulate cortex; cognitive change; cognitive control; cognitive performance; disability; disorder risk; experience; follow up assessment; functional MRI scan; imaging study; improved; lifetime risk; member; memory process; middle age; neural network; neuroimaging; neuropathology; peer; processing speed; programs; prospective

Dementia is the fifth most common cause of disability and death with a lifetime risk of 40% in the U.S. population. It is a costly disease, with estimates exceeding $236 billion annually, and is the only top cause of death for which neither a prevention nor cure is available. Dementia is typically preceded by milder forms of cognitive impairment (CI). Previous research by members of this investigative team have found that CI is more common among World Trade Center responders, relative to age-matched normative samples, approximating 12-14% in two separate studies. Further, among a different sample of 99 WTC responders in the Stony Brook health monitoring program (half of whom had CI) also studied by this team, reduced global mean cortical thickness and thickness across 21/34 subregions was found among those with CI. While the etiology of CI among WTC responders is unknown, preliminary data suggests that Alzheimer’s neuropathology may be one major source, as reflected in specific cognitive domains impacted (e.g., memory), as well as plasma biomarkers and atrophy of enthorhinal and temporal cortices. In addition to structural neuroimaging data, resting state functional MRI (RS-fMRI) data have been acquired among a sample of 99 WTC responders, approximately half of whom had CI at the time of scanning (Time Ascan). Given recent findings on the significance of RS data as a stable set of biomarkers for understanding disease risk, this proposal seeks first to leverage these existing data for determining RS connectivity differences among those with and without CI, as well as relationships with memory and processing speed. As a second aim, it will identify relationships among metrics of RS-fMRI network connectivity and cognition four years following the initial scan among 80 participants (Time Ascan®Time Bcog ). As an exploratory aim, it will characterize changes in RS network connectivity among 25 participants with progressing cognitive decline over four years and 25 with continued unimpaired cognition over four years by adding a RS-fMRI scan four years following the initial scan (Time Bscan) during the two-year study period. These results will inform a study that will aim to identify (with a larger sample) how and to what extent RS fMRI metrics can be used for predicting cognitive change in WTC responders.

痴呆症是导致残疾和死亡的第五大常见原因，其终生患病风险为 40% 美国人口。这是一种代价高昂的疾病，估计每年造成的损失超过 2,360 亿美元，并且是 唯一无法预防或治愈的首要死因。痴呆症通常是 随后出现较轻微的认知障碍 (CI)。本组织成员之前的研究 调查小组发现，CI 在世贸中心响应人员中更为常见， 相对于年龄匹配的标准样本，两项独立研究中的这一比例约为 12-14%。 此外，在石溪健康监测中的 99 名世贸中心响应者的不同样本中 该团队也研究了该项目（其中一半患有 CI），降低了全球平均皮质厚度 在具有 CI 的区域中发现了 21/34 个分区的厚度。 CI 的病因学 世贸中心响应者中的情况尚不清楚，初步数据表明阿尔茨海默病的神经病理学 可能是主要来源之一，反映在受影响的特定认知领域（例如记忆）， 以及血浆生物标志物和内嗅皮质和颞叶皮质萎缩。此外 已获取结构神经影像数据、静息态功能磁共振成像 (RS-fMRI) 数据 在 99 名 WTC 响应者样本中，其中大约一半在响应时患有 CI 扫描（时间Ascan）。鉴于最近关于 RS 数据作为一组稳定数据的重要性的发现 为了了解疾病风险的生物标志物，该提案首先寻求利用这些现有的 用于确定有和没有 CI 的 RS 连接差异的数据，以及 与内存和处理速度的关系。作为第二个目标，它将确定关系 初次扫描四年后 RS-fMRI 网络连接和认知的指标 80 名参与者（Time Ascan®Time Bcog）。作为一个探索性目标，它将描述 25 名参与者的 RS 网络连接发生变化，认知能力逐渐下降 通过添加 RS-fMRI，在四年多的时间里，25 岁​​的患者认知能力在四年内持续未受损 在两年的研究期间，在初次扫描（时间 Bscan）四年后进行扫描。这些 结果将为旨在确定（使用更大样本）如何以及在何种程度上确定的研究提供信息 RS fMRI 指标可用于预测 WTC 响应者的认知变化。