Using Resting State Functional MRI to Predict Cognitive Decline among World Trade Center Responders
使用静息态功能 MRI 预测世贸中心急救人员的认知能力下降
基本信息
- 批准号:10315069
- 负责人:
- 金额:$ 24.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAlzheimer&aposs DiseaseAtrophicBiological MarkersBrainCaringCause of DeathCessation of lifeChronicCognitionCognitiveCommunitiesCost of IllnessCouplingDataDementiaDiagnosticDorsalEarly identificationEtiologyFunctional Magnetic Resonance ImagingFutureGoalsHealthHippocampus (Brain)Impaired cognitionMajor Depressive DisorderMeasuresMemoryMental DepressionModelingMonitorNerve DegenerationNeurophysiology - biologic functionParticipantPatternPerformancePlasmaPopulationPost-Traumatic Stress DisordersPrefrontal CortexPreventionProcessReportingResearchRestSamplingScanningSeveritiesSourceStructureSuggestionSurveillance ProgramSurvivorsSymptomsTemporal LobeThickTimeTraumaVisitWellness ProgramWorld Healthcingulate cortexcognitive changecognitive controlcognitive performancedisabilitydisorder riskexperiencefollow up assessmentfunctional MRI scanimaging studyimprovedlifetime riskmembermemory processmiddle ageneural networkneuroimagingneuropathologypeerprocessing speedprogramsprospective
项目摘要
Dementia is the fifth most common cause of disability and death with a lifetime risk of 40% in the
U.S. population. It is a costly disease, with estimates exceeding $236 billion annually, and is the
only top cause of death for which neither a prevention nor cure is available. Dementia is typically
preceded by milder forms of cognitive impairment (CI). Previous research by members of this
investigative team have found that CI is more common among World Trade Center responders,
relative to age-matched normative samples, approximating 12-14% in two separate studies.
Further, among a different sample of 99 WTC responders in the Stony Brook health monitoring
program (half of whom had CI) also studied by this team, reduced global mean cortical thickness
and thickness across 21/34 subregions was found among those with CI. While the etiology of CI
among WTC responders is unknown, preliminary data suggests that Alzheimer’s neuropathology
may be one major source, as reflected in specific cognitive domains impacted (e.g., memory),
as well as plasma biomarkers and atrophy of enthorhinal and temporal cortices. In addition to
structural neuroimaging data, resting state functional MRI (RS-fMRI) data have been acquired
among a sample of 99 WTC responders, approximately half of whom had CI at the time of
scanning (Time Ascan). Given recent findings on the significance of RS data as a stable set of
biomarkers for understanding disease risk, this proposal seeks first to leverage these existing
data for determining RS connectivity differences among those with and without CI, as well as
relationships with memory and processing speed. As a second aim, it will identify relationships
among metrics of RS-fMRI network connectivity and cognition four years following the initial scan
among 80 participants (Time Ascan®Time Bcog ). As an exploratory aim, it will characterize
changes in RS network connectivity among 25 participants with progressing cognitive decline
over four years and 25 with continued unimpaired cognition over four years by adding a RS-fMRI
scan four years following the initial scan (Time Bscan) during the two-year study period. These
results will inform a study that will aim to identify (with a larger sample) how and to what extent
RS fMRI metrics can be used for predicting cognitive change in WTC responders.
痴呆症是导致残疾和死亡的第五大常见原因,在美国,其终生风险为40%
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sara L. Weisenbach其他文献
Current Understanding of the Neurobiology and Longitudinal Course of Geriatric Depression
- DOI:
10.1007/s11920-014-0463-y - 发表时间:
2014-07-16 - 期刊:
- 影响因子:6.700
- 作者:
Sara L. Weisenbach;Anand Kumar - 通讯作者:
Anand Kumar
Treatment resistant late-life depression: A narrative review of psychosocial risk factors, non-pharmacological interventions, and the role of clinical phenotyping
治疗抵抗性老年期抑郁症:社会心理风险因素、非药物干预及临床表型作用的叙述性综述
- DOI:
10.1016/j.jad.2024.04.017 - 发表时间:
2024-07-01 - 期刊:
- 影响因子:4.900
- 作者:
Regan E. Patrick;Rebecca A. Dickinson;Melanie T. Gentry;Joseph U. Kim;Lauren E. Oberlin;Soohyun Park;Jessica L. Principe;Antonio L. Teixeira;Sara L. Weisenbach - 通讯作者:
Sara L. Weisenbach
A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression
- DOI:
10.1007/s11065-019-09424-5 - 发表时间:
2020-01-15 - 期刊:
- 影响因子:5.000
- 作者:
Katie L. Bessette;Aimee J. Karstens;Natania A. Crane;Amy T. Peters;Jonathan P. Stange;Kathleen H. Elverman;Sarah Shizuko Morimoto;Sara L. Weisenbach;Scott A. Langenecker - 通讯作者:
Scott A. Langenecker
Sara L. Weisenbach的其他文献
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{{ truncateString('Sara L. Weisenbach', 18)}}的其他基金
Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
- 批准号:
10674284 - 财政年份:2022
- 资助金额:
$ 24.98万 - 项目类别:
Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
- 批准号:
10358571 - 财政年份:2018
- 资助金额:
$ 24.98万 - 项目类别:
Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
- 批准号:
10288749 - 财政年份:2018
- 资助金额:
$ 24.98万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8204078 - 财政年份:2012
- 资助金额:
$ 24.98万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8426006 - 财政年份:2012
- 资助金额:
$ 24.98万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8840084 - 财政年份:2012
- 资助金额:
$ 24.98万 - 项目类别:














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