Emotion Regulation in Depression and the Aging Brain

抑郁症和大脑老化的情绪调节

• 批准号: 10288749
• 负责人: Sara L. Weisenbach
• 金额: $ 39.77万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-24 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288749
• 关键词: Adult; Affective; Age; Age of Onset; Aging; Alzheimer' s Disease; Amygdaloid structure; Attention; Award; Behavioral; Chronic; Cognitive; Communities; Decision Making; Depressed mood; Disease; Disease Marker; Education; Elderly; Emotions; Face; Female; Funding; Goals; Health; Impaired cognition; Individual; Investigation; Literature; Major Depressive Disorder; Measures; Mediator of activation protein; Mental Depression; Modeling; Nerve Degeneration; Neurodegenerative Disorders; Participant; Patient Recruitments; Patient Self-Report; Pattern; Perception; Population; Prefrontal Cortex; Prevalence; Process; Protocols documentation; Reporting; Research Domain Criteria; Sampling; Sampling Studies; Severities; Sex Differences; Social Interaction; Stimulus; Stress; Time; Work; aging brain; amnestic mild cognitive impairment; base; chronic depression; cognitive control; depressive symptoms; disability; distraction; emotion dysregulation; emotion regulation; executive function; improved; male; multimodality; neuroimaging; neuropsychiatry; parent grant; response; sex; skills; symptomatology; tool; young adult

Emotion processing skills (EPS), include 1) attention to emotions; 2) basic perception of emotions; and 3) strategies that people use to regulate their emotions. Studies from our group and others have shown that these three constructs occur at different stages of emotion processing. EPS are impacted by demographic variables, including age and sex, as well as neuropsychiatric illnesses, including Major Depression, and neurodegenerative conditions, such as Alzheimer’s Disease. As people age in good health, they demonstrate generally improved perception for and attention to positive stimuli, poorer perception for and attention to negative stimuli, and different patterns of emotion regulation (ER) skills. In addition to age, EPS are moderated by sex. For example, in studies of young adult and adult populations, females tend to demonstrate stronger facial emotion perception skills relative to males, yet more frequently engage in potentially maladaptive ER strategies during times of stress (i.e., rumination) that may contribute to sex differences in depression prevalence. Patterns of sex differences in EPS during late-middle and older age are less clear, and it remains unknown how EPS worsen during abnormal aging processes, such as in the case of depressive symptomatology and neurodegenerative disease. The currently funded R01 Award aims to a) characterize sex as a moderator of ER during late middle and older age (55-79); b) illustrate how ER is moderated by abnormal affective aging (e.g., depression), and c) measure executive functioning (EF) as a partial mediator of ER (EF declines with age and depression, and is known to be critical to successful ER). As an exploratory aim, we aim to model interactions of sex and disease. We study these constructs multi-modally, using self-report, behavioral, and neuroimaging tools, in line with the Research Domain Criteria. This Supplement would enable us to add a sample of individuals with amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s disease (AD) to the existing protocol. The sample will be stratified for depression symptom severity, age, and education, similar to the original proposal, as well as with regard to cognitive severity categorization (aMCI versus early AD) . The sample will be drawn from the SBU Center of Excellence for Alzheimer’s Disease (CEAD).

情绪处理技能（EPS），包括1)对情绪的关注；2)情绪的基本知觉；和3)