Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
基本信息
- 批准号:10674284
- 负责人:
- 金额:$ 48.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-22 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectiveAgeAge of OnsetAgingAmygdaloid structureAttentionBehavioralChronicCognitionCognitive agingDataDecision MakingDepressed moodDiagnosisDiseaseDisease MarkerElderlyEmotionsExhibitsFaceFemaleFoundationsGoalsHealthIndividualInvestigationKnowledgeLeadLiteratureMajor Depressive DisorderMeasuresMediatingMediator of activation proteinMental DepressionModelingMood DisordersOutcomePatient Self-ReportPatternPerceptionPersonsPopulationPrefrontal CortexPrevalenceProcessPsychopathologyRegulationReportingResearch Domain CriteriaRoleSamplingSeveritiesSeverity of illnessSex DifferencesSocial InteractionStimulusStressTimeWomanWorkage effectaging brainattentional biasbasechronic depressiondepressive symptomsdesigndisabilitydistractionemotion dysregulationemotion regulationexecutive functionimprovedindexingmalemenmultimodalityneuroimagingneuropsychiatryrelating to nervous systemresponseruminationsexskillssuccesssymptomatologytherapy developmenttoolyoung adult
项目摘要
Emotion processing skills (EPS), include 1) attention to emotions (e.g., attention bias to positive versus
negative emotions), 2) basic perception of emotions; and 3) strategies that people use to regulate their
emotions. Studies from our group and others have shown that these three constructs occur at different stages
of emotion processing. EPS are impacted by demographic variables, including age and sex, as well as
neuropsychiatric illnesses, including Major Depression. As people age in good health, they demonstrate
generally improved perception for and attention to positive stimuli, poorer perception for and attention to
negative stimuli, and different patterns of emotion regulation (ER) skills. In addition to age, EPS are moderated
by sex. For example, in studies of young adult and adult populations, females tend to demonstrate stronger
facial emotion perception skills relative to males, yet more frequently engage in potentially maladaptive ER
strategies during times of stress (i.e., rumination) that may contribute to sex differences in depression
prevalence. Patterns of sex differences in EPS during late-middle and older age (i.e., 55 years and older) are
less clear, and it remains unknown how EPS worsen during abnormal aging processes, such as in the case of
depression. Our initial work demonstrating the negative impact of depression on EPS and fronto-limbic circuitry
lays the foundation for this investigation. Given known depression-by-age interactions on cognitive aging, it is
imperative that we understand how sex and EPS are involved in depression among older people, as opposed
to assuming that what we know about EPS from younger individuals is applicable to those in late-middle and
older age. This proposal will focus primarily on the ER aspect of EPS, given its more proximal relationship to
mood disorders and its characterization as the primary feature of depression in some models. At the same
time, we will comprehensively measure EPS, as described in the Approach section. This proposal will: a)
characterize sex as a moderator of ER during late middle and older age (55-79); b) illustrate how ER is
moderated by abnormal affective aging (e.g., depression), and c) measure executive functioning (EF) as a
partial mediator of ER, given that EF declines with age and depression, and is known to be critical to
successful affective regulation. As an exploratory aim, we will model interactions of sex and disease. We will
study these constructs multi-modally, using self-report, behavioral, and neuroimaging tools, in line with the
Research Domain Criteria. In order to achieve a sample that is evenly distributed across the age range
sampled, the design is stratified for age (in 5-year epochs), depression status (i.e., never depressed, mild,
moderate depression severity) and sex, for a total sample of 180 individuals with usable data from all aspects
of the study. This study will clarify the effect of sex and depression on processes central to psychopathology in
older age, leading to the development of an intervention for optimizing ER in older adults that accounts for the
impact of sex and disease severity and chronicity, as well as important relationships between EF and ER.!
!
情绪处理技能(EPS),包括1)对情绪的注意(例如,对积极情绪的注意偏向与对消极情绪的注意偏向)
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies.
- DOI:10.1176/appi.focus.20180031
- 发表时间:2019-01
- 期刊:
- 影响因子:0
- 作者:S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott
- 通讯作者:S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott
Linking late life depression and Alzheimer's disease: mechanisms and resilience.
- DOI:10.1007/s40473-019-00180-7
- 发表时间:2019
- 期刊:
- 影响因子:1.7
- 作者:Weisenbach SL;Kim J;Hammers D;Konopacki K;Koppelmans V
- 通讯作者:Koppelmans V
Public health efforts toward reducing depression in older people.
旨在减少老年人抑郁症的公共卫生努力。
- DOI:10.1017/s1041610220003865
- 发表时间:2021
- 期刊:
- 影响因子:7
- 作者:Khan,Nida;Weisenbach,SaraL
- 通讯作者:Weisenbach,SaraL
Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation.
- DOI:10.1002/gps.4982
- 发表时间:2019-03
- 期刊:
- 影响因子:4
- 作者:Kim JU;Weisenbach SL;Zald DH
- 通讯作者:Zald DH
Questioning the Effort Hypothesis That Depressed Patients Perform Disproportionately Worse on Effortful Cognitive Tasks.
- DOI:10.1177/0031512519898356
- 发表时间:2020-04
- 期刊:
- 影响因子:1.6
- 作者:Hammers DB;Weisenbach S
- 通讯作者:Weisenbach S
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Sara L. Weisenbach其他文献
Current Understanding of the Neurobiology and Longitudinal Course of Geriatric Depression
- DOI:
10.1007/s11920-014-0463-y - 发表时间:
2014-07-16 - 期刊:
- 影响因子:6.700
- 作者:
Sara L. Weisenbach;Anand Kumar - 通讯作者:
Anand Kumar
Treatment resistant late-life depression: A narrative review of psychosocial risk factors, non-pharmacological interventions, and the role of clinical phenotyping
治疗抵抗性老年期抑郁症:社会心理风险因素、非药物干预及临床表型作用的叙述性综述
- DOI:
10.1016/j.jad.2024.04.017 - 发表时间:
2024-07-01 - 期刊:
- 影响因子:4.900
- 作者:
Regan E. Patrick;Rebecca A. Dickinson;Melanie T. Gentry;Joseph U. Kim;Lauren E. Oberlin;Soohyun Park;Jessica L. Principe;Antonio L. Teixeira;Sara L. Weisenbach - 通讯作者:
Sara L. Weisenbach
A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression
- DOI:
10.1007/s11065-019-09424-5 - 发表时间:
2020-01-15 - 期刊:
- 影响因子:5.000
- 作者:
Katie L. Bessette;Aimee J. Karstens;Natania A. Crane;Amy T. Peters;Jonathan P. Stange;Kathleen H. Elverman;Sarah Shizuko Morimoto;Sara L. Weisenbach;Scott A. Langenecker - 通讯作者:
Scott A. Langenecker
Sara L. Weisenbach的其他文献
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{{ truncateString('Sara L. Weisenbach', 18)}}的其他基金
Using Resting State Functional MRI to Predict Cognitive Decline among World Trade Center Responders
使用静息态功能 MRI 预测世贸中心急救人员的认知能力下降
- 批准号:
10315069 - 财政年份:2021
- 资助金额:
$ 48.69万 - 项目类别:
Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
- 批准号:
10358571 - 财政年份:2018
- 资助金额:
$ 48.69万 - 项目类别:
Emotion Regulation in Depression and the Aging Brain
抑郁症和大脑老化的情绪调节
- 批准号:
10288749 - 财政年份:2018
- 资助金额:
$ 48.69万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8204078 - 财政年份:2012
- 资助金额:
$ 48.69万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8426006 - 财政年份:2012
- 资助金额:
$ 48.69万 - 项目类别:
Cognitive, Clinical and Neural Markers of Late Life Depression
晚年抑郁症的认知、临床和神经标志物
- 批准号:
8840084 - 财政年份:2012
- 资助金额:
$ 48.69万 - 项目类别:
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