Emotion Regulation in Depression and the Aging Brain

抑郁症和大脑老化的情绪调节

• 批准号: 10674284
• 负责人: Sara L. Weisenbach
• 金额: $ 48.69万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674284
• 关键词: Address; Adult; Affective; Age; Age of Onset; Aging; Amygdaloid structure; Attention; Behavioral; Chronic; Cognition; Cognitive aging; Data; Decision Making; Depressed mood; Diagnosis; Disease; Disease Marker; Elderly; Emotions; Exhibits; Face; Female; Foundations; Goals; Health; Individual; Investigation; Knowledge; Lead; Literature; Major Depressive Disorder; Measures; Mediating; Mediator of activation protein; Mental Depression; Modeling; Mood Disorders; Outcome; Patient Self-Report; Pattern; Perception; Persons; Population; Prefrontal Cortex; Prevalence; Process; Psychopathology; Regulation; Reporting; Research Domain Criteria; Role; Sampling; Severities; Severity of illness; Sex Differences; Social Interaction; Stimulus; Stress; Time; Woman; Work; age effect; aging brain; attentional bias; base; chronic depression; depressive symptoms; design; disability; distraction; emotion dysregulation; emotion regulation; executive function; improved; indexing; male; men; multimodality; neuroimaging; neuropsychiatry; relating to nervous system; response; rumination; sex; skills; success; symptomatology; therapy development; tool; young adult

Emotion processing skills (EPS), include 1) attention to emotions (e.g., attention bias to positive versus negative emotions), 2) basic perception of emotions; and 3) strategies that people use to regulate their emotions. Studies from our group and others have shown that these three constructs occur at different stages of emotion processing. EPS are impacted by demographic variables, including age and sex, as well as neuropsychiatric illnesses, including Major Depression. As people age in good health, they demonstrate generally improved perception for and attention to positive stimuli, poorer perception for and attention to negative stimuli, and different patterns of emotion regulation (ER) skills. In addition to age, EPS are moderated by sex. For example, in studies of young adult and adult populations, females tend to demonstrate stronger facial emotion perception skills relative to males, yet more frequently engage in potentially maladaptive ER strategies during times of stress (i.e., rumination) that may contribute to sex differences in depression prevalence. Patterns of sex differences in EPS during late-middle and older age (i.e., 55 years and older) are less clear, and it remains unknown how EPS worsen during abnormal aging processes, such as in the case of depression. Our initial work demonstrating the negative impact of depression on EPS and fronto-limbic circuitry lays the foundation for this investigation. Given known depression-by-age interactions on cognitive aging, it is imperative that we understand how sex and EPS are involved in depression among older people, as opposed to assuming that what we know about EPS from younger individuals is applicable to those in late-middle and older age. This proposal will focus primarily on the ER aspect of EPS, given its more proximal relationship to mood disorders and its characterization as the primary feature of depression in some models. At the same time, we will comprehensively measure EPS, as described in the Approach section. This proposal will: a) characterize sex as a moderator of ER during late middle and older age (55-79); b) illustrate how ER is moderated by abnormal affective aging (e.g., depression), and c) measure executive functioning (EF) as a partial mediator of ER, given that EF declines with age and depression, and is known to be critical to successful affective regulation. As an exploratory aim, we will model interactions of sex and disease. We will study these constructs multi-modally, using self-report, behavioral, and neuroimaging tools, in line with the Research Domain Criteria. In order to achieve a sample that is evenly distributed across the age range sampled, the design is stratified for age (in 5-year epochs), depression status (i.e., never depressed, mild, moderate depression severity) and sex, for a total sample of 180 individuals with usable data from all aspects of the study. This study will clarify the effect of sex and depression on processes central to psychopathology in older age, leading to the development of an intervention for optimizing ER in older adults that accounts for the impact of sex and disease severity and chronicity, as well as important relationships between EF and ER.! !

情绪处理技能（EPS），包括1)对情绪的注意（例如，对积极情绪的注意偏向与对消极情绪的注意偏向）

项目成果

A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies.

• DOI: 10.1176/appi.focus.20180031
• 发表时间: 2019-01
• 期刊: Focus
• 作者: S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott

Linking late life depression and Alzheimer's disease: mechanisms and resilience.

• DOI: 10.1007/s40473-019-00180-7
• 发表时间: 2019
• 期刊: Current behavioral neuroscience reports
• 影响因子: 1.7
• 作者: Weisenbach SL;Kim J;Hammers D;Konopacki K;Koppelmans V
• 通讯作者: Koppelmans V

Public health efforts toward reducing depression in older people.

旨在减少老年人抑郁症的公共卫生努力。

• DOI: 10.1017/s1041610220003865
• 发表时间: 2021
• 期刊: International psychogeriatrics
• 影响因子: 7
• 作者: Khan,Nida;Weisenbach,SaraL
• 通讯作者: Weisenbach,SaraL

Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation.

• DOI: 10.1002/gps.4982
• 发表时间: 2019-03
• 期刊: International journal of geriatric psychiatry
• 影响因子: 4
• 作者: Kim JU;Weisenbach SL;Zald DH
• 通讯作者: Zald DH

Questioning the Effort Hypothesis That Depressed Patients Perform Disproportionately Worse on Effortful Cognitive Tasks.

• DOI: 10.1177/0031512519898356
• 发表时间: 2020-04
• 期刊: Perceptual and motor skills
• 影响因子: 1.6
• 作者: Hammers DB;Weisenbach S
• 通讯作者: Weisenbach S