Emotion Regulation in Depression and the Aging Brain

抑郁症和大脑老化的情绪调节

• 批准号: 10674284
• 负责人: Sara L. Weisenbach
• 金额: $ 48.69万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674284
• 关键词: Address; Adult; Affective; Age; Age of Onset; Aging; Amygdaloid structure; Attention; Behavioral; Chronic; Cognition; Cognitive aging; Data; Decision Making; Depressed mood; Diagnosis; Disease; Disease Marker; Elderly; Emotions; Exhibits; Face; Female; Foundations; Goals; Health; Individual; Investigation; Knowledge; Lead; Literature; Major Depressive Disorder; Measures; Mediating; Mediator of activation protein; Mental Depression; Modeling; Mood Disorders; Outcome; Patient Self-Report; Pattern; Perception; Persons; Population; Prefrontal Cortex; Prevalence; Process; Psychopathology; Regulation; Reporting; Research Domain Criteria; Role; Sampling; Severities; Severity of illness; Sex Differences; Social Interaction; Stimulus; Stress; Time; Woman; Work; age effect; aging brain; attentional bias; base; chronic depression; depressive symptoms; design; disability; distraction; emotion dysregulation; emotion regulation; executive function; improved; indexing; male; men; multimodality; neuroimaging; neuropsychiatry; relating to nervous system; response; rumination; sex; skills; success; symptomatology; therapy development; tool; young adult

Emotion processing skills (EPS), include 1) attention to emotions (e.g., attention bias to positive versus negative emotions), 2) basic perception of emotions; and 3) strategies that people use to regulate their emotions. Studies from our group and others have shown that these three constructs occur at different stages of emotion processing. EPS are impacted by demographic variables, including age and sex, as well as neuropsychiatric illnesses, including Major Depression. As people age in good health, they demonstrate generally improved perception for and attention to positive stimuli, poorer perception for and attention to negative stimuli, and different patterns of emotion regulation (ER) skills. In addition to age, EPS are moderated by sex. For example, in studies of young adult and adult populations, females tend to demonstrate stronger facial emotion perception skills relative to males, yet more frequently engage in potentially maladaptive ER strategies during times of stress (i.e., rumination) that may contribute to sex differences in depression prevalence. Patterns of sex differences in EPS during late-middle and older age (i.e., 55 years and older) are less clear, and it remains unknown how EPS worsen during abnormal aging processes, such as in the case of depression. Our initial work demonstrating the negative impact of depression on EPS and fronto-limbic circuitry lays the foundation for this investigation. Given known depression-by-age interactions on cognitive aging, it is imperative that we understand how sex and EPS are involved in depression among older people, as opposed to assuming that what we know about EPS from younger individuals is applicable to those in late-middle and older age. This proposal will focus primarily on the ER aspect of EPS, given its more proximal relationship to mood disorders and its characterization as the primary feature of depression in some models. At the same time, we will comprehensively measure EPS, as described in the Approach section. This proposal will: a) characterize sex as a moderator of ER during late middle and older age (55-79); b) illustrate how ER is moderated by abnormal affective aging (e.g., depression), and c) measure executive functioning (EF) as a partial mediator of ER, given that EF declines with age and depression, and is known to be critical to successful affective regulation. As an exploratory aim, we will model interactions of sex and disease. We will study these constructs multi-modally, using self-report, behavioral, and neuroimaging tools, in line with the Research Domain Criteria. In order to achieve a sample that is evenly distributed across the age range sampled, the design is stratified for age (in 5-year epochs), depression status (i.e., never depressed, mild, moderate depression severity) and sex, for a total sample of 180 individuals with usable data from all aspects of the study. This study will clarify the effect of sex and depression on processes central to psychopathology in older age, leading to the development of an intervention for optimizing ER in older adults that accounts for the impact of sex and disease severity and chronicity, as well as important relationships between EF and ER.! !

情绪处理技能（EPS），包括1）对情绪的关注（例如，注意力偏向于正面， 消极情绪），2）情绪的基本感知; 3）人们用来调节他们的策略。 情绪我们小组和其他人的研究表明，这三种结构发生在不同的阶段， 情绪处理的过程EPS受人口统计变量的影响，包括年龄和性别，以及 神经精神疾病，包括重度抑郁症。随着人们身体健康地变老， 对积极刺激的感知和注意力普遍改善，对积极刺激的感知和注意力较差， 负性刺激，以及不同的情绪调节（ER）技能模式。除年龄外，EPS也是适度的 按性别分列例如，在对年轻人和成年人的研究中，女性往往表现出更强的 面部情绪感知技能相对于男性，但更频繁地从事潜在的适应不良ER 在压力时期的策略（即，反刍），这可能有助于抑郁症的性别差异 普遍性。中年晚期和老年期EPS的性别差异模式（即，55岁及以上） 不太清楚，并且仍然不知道EPS在异常老化过程中如何恶化，例如在 萧条我们的初步工作证明了抑郁症对EPS和额叶边缘回路的负面影响 为这次调查奠定了基础。鉴于已知的抑郁症与认知老化的年龄相互作用， 我们必须了解性和EPS如何参与老年人的抑郁症， 假设我们从年轻人那里了解到的EPS适用于那些中晚期的人， 年纪大了本提案将主要关注EPS的ER方面，因为其与以下方面的关系更密切： 在一些模型中，情绪障碍及其特征是抑郁症的主要特征。在同一 届时，我们将全面衡量每股收益，如方法部分所述。该提案将：（a） 在中年晚期和老年（55-79岁），将性别描述为ER的调节因素; B）说明ER如何 由异常情感老化（例如，抑郁症），和c）测量执行功能（EF）作为一个 ER的部分介质，鉴于EF随年龄和抑郁症而下降，并且已知对 成功的情感调节作为一个探索性的目标，我们将模拟性和疾病的相互作用。我们将 研究这些结构多模式，使用自我报告，行为，和神经成像工具，符合 研究领域标准。为了获得一个在年龄范围内均匀分布的样本 取样后，将设计按年龄（以5年为一个时期），抑郁状态（即，从不抑郁，温和， 中度抑郁症严重程度）和性别，总样本量为180人，提供各方面的可用数据 的研究。这项研究将阐明性别和抑郁对精神病理学核心过程的影响， 老年，导致开发一种干预措施，用于优化老年人的ER， 性别和疾病严重程度和慢性程度的影响，以及EF和ER之间的重要关系。 !

项目成果

A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies.

• DOI: 10.1176/appi.focus.20180031
• 发表时间: 2019-01
• 期刊: Focus
• 作者: S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott

Linking late life depression and Alzheimer's disease: mechanisms and resilience.

• DOI: 10.1007/s40473-019-00180-7
• 发表时间: 2019
• 期刊: Current behavioral neuroscience reports
• 影响因子: 1.7
• 作者: Weisenbach SL;Kim J;Hammers D;Konopacki K;Koppelmans V
• 通讯作者: Koppelmans V

Public health efforts toward reducing depression in older people.

旨在减少老年人抑郁症的公共卫生努力。

• DOI: 10.1017/s1041610220003865
• 发表时间: 2021
• 期刊: International psychogeriatrics
• 影响因子: 7
• 作者: Khan,Nida;Weisenbach,SaraL
• 通讯作者: Weisenbach,SaraL

Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation.

• DOI: 10.1002/gps.4982
• 发表时间: 2019-03
• 期刊: International journal of geriatric psychiatry
• 影响因子: 4
• 作者: Kim JU;Weisenbach SL;Zald DH
• 通讯作者: Zald DH

Questioning the Effort Hypothesis That Depressed Patients Perform Disproportionately Worse on Effortful Cognitive Tasks.

• DOI: 10.1177/0031512519898356
• 发表时间: 2020-04
• 期刊: Perceptual and motor skills
• 影响因子: 1.6
• 作者: Hammers DB;Weisenbach S
• 通讯作者: Weisenbach S