Emotion Regulation in Depression and the Aging Brain

抑郁症和大脑老化的情绪调节

基本信息

批准号：
10674284
负责人：
Sara L. Weisenbach
金额：
$ 48.69万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-22 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10674284
关键词：
Address Adult Affective Age Age of Onset Aging Amygdaloid structure Attention Behavioral Chronic Cognition Cognitive aging Data Decision Making Depressed mood Diagnosis Disease Disease Marker Elderly Emotions Exhibits Face Female Foundations Goals Health Individual Investigation Knowledge Lead Literature Major Depressive Disorder Measures Mediating Mediator of activation protein Mental Depression Modeling Mood Disorders Outcome Patient Self-Report Pattern Perception Persons Population Prefrontal Cortex Prevalence Process Psychopathology Regulation Reporting Research Domain Criteria Role Sampling Severities Severity of illness Sex Differences Social Interaction Stimulus Stress Time Woman Work age effect aging brain attentional bias base chronic depression depressive symptoms design disability distraction emotion dysregulation emotion regulation executive function improved indexing male men multimodality neuroimaging neuropsychiatry relating to nervous system response rumination sex skills success symptomatology therapy development tool young adult

项目摘要

Emotion processing skills (EPS), include 1) attention to emotions (e.g., attention bias to positive versus negative emotions), 2) basic perception of emotions; and 3) strategies that people use to regulate their emotions. Studies from our group and others have shown that these three constructs occur at different stages of emotion processing. EPS are impacted by demographic variables, including age and sex, as well as neuropsychiatric illnesses, including Major Depression. As people age in good health, they demonstrate generally improved perception for and attention to positive stimuli, poorer perception for and attention to negative stimuli, and different patterns of emotion regulation (ER) skills. In addition to age, EPS are moderated by sex. For example, in studies of young adult and adult populations, females tend to demonstrate stronger facial emotion perception skills relative to males, yet more frequently engage in potentially maladaptive ER strategies during times of stress (i.e., rumination) that may contribute to sex differences in depression prevalence. Patterns of sex differences in EPS during late-middle and older age (i.e., 55 years and older) are less clear, and it remains unknown how EPS worsen during abnormal aging processes, such as in the case of depression. Our initial work demonstrating the negative impact of depression on EPS and fronto-limbic circuitry lays the foundation for this investigation. Given known depression-by-age interactions on cognitive aging, it is imperative that we understand how sex and EPS are involved in depression among older people, as opposed to assuming that what we know about EPS from younger individuals is applicable to those in late-middle and older age. This proposal will focus primarily on the ER aspect of EPS, given its more proximal relationship to mood disorders and its characterization as the primary feature of depression in some models. At the same time, we will comprehensively measure EPS, as described in the Approach section. This proposal will: a) characterize sex as a moderator of ER during late middle and older age (55-79); b) illustrate how ER is moderated by abnormal affective aging (e.g., depression), and c) measure executive functioning (EF) as a partial mediator of ER, given that EF declines with age and depression, and is known to be critical to successful affective regulation. As an exploratory aim, we will model interactions of sex and disease. We will study these constructs multi-modally, using self-report, behavioral, and neuroimaging tools, in line with the Research Domain Criteria. In order to achieve a sample that is evenly distributed across the age range sampled, the design is stratified for age (in 5-year epochs), depression status (i.e., never depressed, mild, moderate depression severity) and sex, for a total sample of 180 individuals with usable data from all aspects of the study. This study will clarify the effect of sex and depression on processes central to psychopathology in older age, leading to the development of an intervention for optimizing ER in older adults that accounts for the impact of sex and disease severity and chronicity, as well as important relationships between EF and ER.! !

情绪处理技巧（EP），包括1）注意情绪（例如，注意积极与积极的偏见负面情绪），2）对情绪的基本感知； 3）人们用来规范其的策略情绪。我们小组和其他人的研究表明，这三个结构发生在不同的阶段情绪处理。 EPS受人口统计学变量的影响，包括年龄和性别，以及神经精神疾病，包括重度抑郁症。随着人们身体健康的年龄，他们证明了通常提高对正刺激的看法和注意力，对较差的感知和注意负面刺激和情绪调节（ER）技能的不同模式。除了年龄，EP还会节省通过性。例如，在对年轻人和成人人群的研究中，女性倾向于表现出更强的面部情感感知技巧相对于男性，但更频繁地从事潜在的适应不良ER 压力时期（即反省）可能导致性别差异的策略流行率。中期和年龄较大（即55岁及以上）的EPS性别差异模式为不太清楚，在异常老化过程中，EPS如何恶化，例如沮丧。我们最初的工作证明了抑郁症对EPS和额叶额叶电路的负面影响为这项调查奠定了基础。考虑到认知衰老的已知抑郁症相互作用，这是当务之急，我们了解性别和EP如何参与老年人的抑郁症，而不是假设我们对年轻人的EPS了解的内容适用于中期中的人和年龄较大。鉴于它与在某些模型中，情绪障碍及其作为抑郁症的主要特征。同样时间，我们将全面测量EPS，如“接近”部分中所述。该提议将：a）将性描述为中期和年龄较大的ER的主持人（55-79）； b）说明ER是如何的由异常情感衰老（例如抑郁症）和c）衡量执行功能（EF）作为一个鉴于EF的年龄和抑郁症的下降，众所周知，ER的部分介体对成功的情感调节。作为探索目的，我们将建模性别和疾病的相互作用。我们将使用自我报告，行为和神经影像工具多模式研究这些构造研究领域标准。为了获得在年龄范围内均匀分布的样本采样，设计为年龄分层（在5年时代），抑郁状态（即，从不抑郁，轻度，中度抑郁症的严重程度）和性别，总共有180名来自各个方面的可用数据的人研究。这项研究将阐明性别和抑郁的影响对心理病理学中心的过程年龄较大，导致开发一种干预措施，以优化老年人的ER 性别和疾病的严重程度和慢性的影响，以及EF和ER之间的重要关系。呢

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies.

DOI：
10.1176/appi.focus.20180031
发表时间：
2019-01
期刊：
Focus
影响因子：
0
作者：
S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott
通讯作者：
S. McClintock;E. Kallioniemi;D. Martin;Joseph U. Kim;S. Weisenbach;C. Abbott

Linking late life depression and Alzheimer's disease: mechanisms and resilience.