Cognition and neuropathology in World Trade Center-exposed FDNY, NYPD, and construction worker responders

暴露于世贸中心的纽约消防局、纽约警察局和建筑工人急救人员的认知和神经病理学

• 批准号: 10314008
• 负责人: SEAN CLOUSTON
• 金额: $ 59.83万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10314008
• 关键词: Cognition; neuropathology; World; Trade; Center

Abstract World Trade Center (WTC) responders were exposed to a mix of tiny dust particles as they participated in rescue and recovery efforts at the WTC in the aftermath of 9/11/2001. A significant number continue to suffer from Post- Traumatic Stress Disorder (PTSD) as a result of their experiences. These may have changed their expectations of brain health as they age. Our team has interrogated the potential for early signs of cognitive aging and has identified higher than expected burden of mild cognitive impairment (MCI) and, surprisingly, changes to physical functional limitations (PFL) common in both physical disability and in neurodegenerative disease. We propose that MCI is arising early because PTSD and inhaled particulate exposures have caused a neurodegenerative disease, resulting in increased Alzheimer’s disease neuropathology. We propose to conduct a large study of WTC-exposed Fire Department of the City of New York (FDNY) responders that includes cognitive functioning profiling alongside state-of-the-art proteomic studies of blood-based biomarkers alongside a PET/MRI study of 30 medically healthy WTC responders using two well-validated positron emission tomography (PET) ligands ([11C]-PiB to measure β-amyloid, and [18F]-Flortaucipir to measure tauopathy). Detailed cognitive testing will help to determine the level of cognitive dysfunction. Simultaneous structural MRI will be used to measure the extent of neurodegeneration. This study is timely because we are in a critical period when neuropathology is emerging and the etiology of the disease is still possible to determine.

抽象的 世界贸易中心 (WTC) 救援人员在参与救援时暴露在微小灰尘颗粒的混合物中 以及 2001 年 9 月 11 日之后世贸中心的恢复工作。相当数量的人继续遭受后 他们的经历导致了创伤性应激障碍（PTSD）。这些可能改变了他们的期望 随着年龄的增长，大脑健康状况也会受到影响。我们的团队研究了认知衰老早期迹象的可能性，并发现 发现轻度认知障碍 (MCI) 的负担高于预期，并且令人惊讶的是，身体状况发生了变化 功能限制（PFL）常见于身体残疾和神经退行性疾病。我们建议 MCI 之所以早期出现，是因为 PTSD 和吸入颗粒物暴露导致了神经退行性病变 疾病，导致阿尔茨海默病神经病理学增加。我们建议进行一项大规模研究 纽约市消防局 (FDNY) 暴露于 WTC 的响应人员，包括认知功能 分析以及基于血液的生物标志物的最先进的蛋白质组学研究以及 PET/MRI 研究 30 名身体健康的 WTC 急救人员使用两种经过充分验证的正电子发射断层扫描 (PET) 配体 （[11C]-PiB 用于测量 β-淀粉样蛋白，[18F]-Flortaucipir 用于测量 tau 蛋白病）。详细的认知测试将有所帮助 以确定认知功能障碍的水平。同步结构 MRI 将用于测量范围 神经退行性变。这项研究是及时的，因为我们正处于神经病理学研究的关键时期 正在出现，并且该疾病的病因仍有可能确定。