Cognition and neuropathology in World Trade Center-exposed FDNY, NYPD, and construction worker responders

摘要 世贸中心(WTC)的救援人员在参与救援时暴露在微小尘埃颗粒的混合物中 9/11/2001事件后，世贸中心的重建工作。相当多的人继续遭受后遗症- 由于他们的经历而导致的创伤应激障碍(PTSD)。这些可能改变了他们的预期 随着年龄的增长，他们的大脑健康状况会有所不同。我们的团队已经询问了认知老化的早期迹象的可能性，并 轻度认知障碍(MCI)的负担高于预期，令人惊讶的是，身体状况发生了变化 功能受限(PFL)在身体残疾和神经退行性疾病中都很常见。我们建议 早期出现MCI是因为创伤后应激障碍和吸入颗粒物暴露导致了神经退行性变 疾病，导致阿尔茨海默病神经病理加重。我们建议对……进行一项大型研究 WTC暴露的纽约市消防局(FDNY)包括认知功能的应答者 在对基于血液的生物标记物进行最新蛋白质组学研究的同时，还进行了一项PET/MRI研究 30名医疗健康的WTC应答者使用两种经过充分验证的正电子发射断层扫描(PET)配体 ([11C]-PIB用于测量β-淀粉样蛋白，[18F]-弗洛托西平用于测量肌萎缩侧索硬化)。详细的认知测试将有所帮助 以确定认知功能障碍的程度。将使用同步结构磁共振来测量范围 神经退行性变。这项研究是及时的，因为我们正处于神经病理学的关键时期 目前仍有可能确定该病的出现和病因。

Abstract World Trade Center (WTC) responders were exposed to a mix of tiny dust particles as they participated in rescue and recovery efforts at the WTC in the aftermath of 9/11/2001. A significant number continue to suffer from Post- Traumatic Stress Disorder (PTSD) as a result of their experiences. These may have changed their expectations of brain health as they age. Our team has interrogated the potential for early signs of cognitive aging and has identified higher than expected burden of mild cognitive impairment (MCI) and, surprisingly, changes to physical functional limitations (PFL) common in both physical disability and in neurodegenerative disease. We propose that MCI is arising early because PTSD and inhaled particulate exposures have caused a neurodegenerative disease, resulting in increased Alzheimer’s disease neuropathology. We propose to conduct a large study of WTC-exposed Fire Department of the City of New York (FDNY) responders that includes cognitive functioning profiling alongside state-of-the-art proteomic studies of blood-based biomarkers alongside a PET/MRI study of 30 medically healthy WTC responders using two well-validated positron emission tomography (PET) ligands ([11C]-PiB to measure β-amyloid, and [18F]-Flortaucipir to measure tauopathy). Detailed cognitive testing will help to determine the level of cognitive dysfunction. Simultaneous structural MRI will be used to measure the extent of neurodegeneration. This study is timely because we are in a critical period when neuropathology is emerging and the etiology of the disease is still possible to determine.