RR&D Research Career Scientist Award Application - Renewal of Margot Damaser SRCS Award

RR

• 批准号: 10316369
• 负责人: MARGOT S. DAMASER
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2028-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10316369
• 关键词: Activities of Daily Living; Advisory Committees; Affect; Agreement; American; Animal Model; Animals; Area; Award; Biomedical Engineering; Birth trauma; Bladder; Book Chapters; Books; Caring; Catheters; Central Nervous System Diseases; Clinic; Clinical; Collaborations; Conscious; Constipation; Development; Device Designs; Device or Instrument Development; Devices; Diabetes Mellitus; Diagnosis; Disease; Elderly; Electric Stimulation; Engineering; Evaluation; Exercise; Extravasation; Fecal Incontinence; Female; Foundations; Functional disorder; Funding; Goals; Grant; Grant Review; Gymnastics; Homing; Human; IACUC; Impairment; Institutes; Interdisciplinary Study; Intestines; Joints; Journals; Kidney; Laboratory Research; Legal patent; Licensing; Manuscripts; Massachusetts; Measures; Medical; Medical Device; Medicine; Mentors; Methods; Modeling; Monitor; Motivation; Multiple Trauma; Muscle; Nanotechnology; Natural regeneration; Nerve; Neurogenic Bladder; Ohio; Organ; Paper; Parachuting; Pelvic Floor Disorders; Pelvic floor structure; Peripheral Nerves; Physical activity; Physiology; Positioning Attribute; Prevalence; Publishing; Recovery; Reference Standards; Regenerative Medicine; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Resistance; Rodent; Role; Running; Scientific Societies; Scientist; Seeds; Services; Source; Spinal cord injury; Stress Urinary Incontinence; System; Technology; Testing; Training; Transact; Translating; Translational Research; Translations; Traumatic Brain Injury; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Urethra; Urinary Incontinence; Urology; Vagina; Veterans; Weight; Weight Lifting; Woman; career; clinical translation; college; diabetic; human subject; innovation; member; minimally invasive; nerve injury; neurotrophic factor; novel; overexpression; pelvic organ prolapse; professor; programs; regenerative; regenerative approach; rehabilitation research; research and development; research in practice; stem cells; translational potential; wireless

Summary/Abstract Dr. Margot Damaser is Senior Research Career Scientist in the RR&D Service of the US Department of Veterans Affairs and Professor of Biomedical Engineering in the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. She is Deputy Director and co-PI of the Advanced Platform Technology Center. Dr. Damaser's research is focused on using principles of engineering, physiology, and regenerative medicine to develop new models and devices for improvement of diagnosis, treatment, and rehabilitation of pelvic floor disorders (PFD): urinary incontinence, fecal incontinence, and pelvic organ prolapse. Rehabilitation of these autonomic organs is an understudied field with great relevance to Veterans, particularly women and those with spinal cord injury or neurogenic disorders. She has initiated development of novel wireless catheter- free technology for monitoring bladder and bowel function during conscious ambulation and activities of daily living. This innovative monitoring system provides a paradigm shift in diagnosis, rehabilitation, and treatment of urinary and fecal incontinence, constipation and voiding dysfunction. In addition, her research focuses on regenerative approaches to treat PFD, including stem cells and/or their secretions, electrical stimulation, and elastogenic nanotechnology. She has made significant advances in this area by demonstrating that treatment with the secretions from stem cells is highly regenerative even when the treatment is given systemically, suggesting minimal invasive therapy could be utilized. In addition, she has demonstrated that electrical stimulation can regenerate peripheral nerves even in situations of impaired regeneration. These treatments are promising to promote rehabilitation, particularly for Veterans with impaired regeneration, such as the elderly, diabetics, and those with polytrauma affecting both nerves and muscles. The over-arching goals of this research is to benefit Veterans. To that end Dr. Damaser has invested effort to translate technology and has 4 issued patents, 3 pending patents, and 1 provisional patent application, as well as 2 licensed technologies, 1 option to license a technology, 1 joint development agreement, and 1 evaluation agreement with multiple companies in the field. In 2019, Dr. Damaser was 1st Place winner for the UroMonitor in the Massachusetts Medical Device Development (M2D2) $200k Challenge, demonstrating the translational potential of her technology. She is thus on track to translate novel diagnosis, treatment and rehabilitation methods to the clinic within the next 10 years. She has obtained funding for her research from VA, NIH, DOD, the State of Ohio, and foundation and corporate sources. In recognition of the significance of her research, Dr. Damaser was elected to the American Institute for Medical and Biological Engineering (AIMBE) in 2014. During the current SRCS award period, Dr. Damaser published 37 research manuscripts, 19 review papers and 4 book chapters. She co-edited a book that has become a standard reference in the field and mentored many young investigators. Dr. Damaser is currently Deputy Director and co-PI of the Advanced Platform Technology Center (2 I50 RX001871), PI of an NIH R21 grant, (R21HD095234), PI of an NIH Other Transaction Award (NIH OT2 OD023873), and co- Investigator on multiple NIH and foundation grants. She served for 12 years as Chair of the local IACUC (2008- 2020) and serves as a member of the Field Advisory Committee to VA ORO in addition to serving on multiple VA and NIH grant review panels. In addition, she uses her research program to train many clinical, scientific, and engineering trainees in research practices, enlarging the impact of her research. In recognition of this effort, Dr. Damaser was awarded the Urology Care Foundation Distinguished Mentor Award in 2020. In her role as co-PI and Deputy Director of the APT Center, Dr. Damaser is in a position to expand her influence to mentor others in conducting productive translational rehabilitation research and development during the upcoming renewal period of her Senior Research Career Scientist Award.

总结/摘要 博士Margot Damaser是美国农业部RR&D服务的高级研究职业科学家。 退伍军人事务部和克利夫兰诊所勒纳医学院生物医学工程教授， 凯斯西储大学她是高级平台技术的副主任和联合PI 中心Damaser博士的研究重点是利用工程学、生理学和再生原理 医学开发新的模式和设备，以改善诊断，治疗和康复， 骨盆底疾病（PFD）：尿失禁、大便失禁和盆腔器官脱垂。康复 这些自主器官是一个未充分研究的领域，与退伍军人，特别是妇女， 脊髓损伤或神经源性疾病患者。她发起了新型无线导管的开发- 在清醒和日常活动期间监测膀胱和肠道功能的免费技术 living.这种创新的监测系统提供了一个范式转变的诊断，康复和治疗， 大小便失禁、便秘和排尿功能障碍。此外，她的研究重点是 治疗PFD的再生方法，包括干细胞和/或其分泌物，电刺激， 弹性纳米技术她在这一领域取得了重大进展， 即使在全身给予治疗时，来自干细胞的分泌物也是高度再生的， 这表明可以使用微创治疗。此外，她还证明， 即使在再生受损的情况下，刺激也可以使周围神经再生。这些治疗 承诺促进康复，特别是对再生受损的退伍军人，如老年人， 糖尿病患者以及神经和肌肉受多发性创伤的患者。本研究的主要目的是 是为了让退伍军人受益为此，Damaser博士投入了大量的精力来翻译技术，并已发布了4份 专利，3项正在申请的专利，1项临时专利申请，以及2项许可技术，1项选择， 许可一项技术，1项联合开发协议，1项与多家公司的评估协议， 外地2019年，Dr. Damaser获得了马萨诸塞州医学院UroMonitor的第一赢家。 设备开发（M2 D2）20万美元挑战赛，展示了她的技术的转化潜力。 因此，她有望将新颖的诊断、治疗和康复方法转化为诊所 未来10年她的研究获得了弗吉尼亚州、国家卫生研究院、国防部、俄亥俄州和基金会的资助 和企业来源。为了表彰她的研究的重要性，Damaser博士被选为 2014年，美国医学与生物工程研究所（AIMBE）。在本届SRCS颁奖期间 在此期间，Damaser博士发表了37篇研究手稿，19篇评论论文和4本书的章节。她合编了 这本书已成为该领域的标准参考书，并指导了许多年轻的研究人员。达马瑟博士 现任高级平台技术中心（2 I50 RX 001871）副主任兼联合PI， NIH R21赠款（R21 HD 095234），NIH其他交易奖的PI（NIH OT 2 OD 023873），以及共同- 多项NIH和基金会赠款的研究者。她曾担任当地IACUC主席12年（2008- 2020年），并担任外地咨询委员会的成员，以VA ORO除了服务于多个 VA和NIH拨款审查小组。此外，她利用她的研究计划，以培训许多临床，科学， 和工程实习生在研究实践中，扩大她的研究的影响。为了表彰这一努力， 博士Damaser于2020年荣获泌尿科护理基金会杰出导师奖。在她的角色 作为APT中心的联合PI和副主任，Damaser博士能够扩大她的影响力， 其他人在即将到来的翻译康复研究和开发 她的高级研究职业科学家奖的续约期。