RR&D Research Career Scientist Award Application - Renewal of Margot Damaser SRCS Award

RR

• 批准号: 10507777
• 负责人: MARGOT S. DAMASER
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2028-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10507777
• 关键词: Activities of Daily Living; Advisory Committees; Affect; Agreement; American; Animal Model; Animals; Area; Award; Biomedical Engineering; Birth trauma; Bladder; Book Chapters; Books; Caring; Catheters; Central Nervous System Diseases; Clinic; Clinical; Collaborations; Conscious; Constipation; Development; Device Designs; Device or Instrument Development; Devices; Diabetes Mellitus; Diagnosis; Disease; Elderly; Electric Stimulation; Engineering; Evaluation; Exercise; Extravasation; Fecal Incontinence; Female; Foundations; Functional disorder; Funding; Goals; Grant; Grant Review; Gymnastics; Homing; Human; IACUC; Impairment; Institutes; Interdisciplinary Study; Intestines; Joints; Journals; Kidney; Laboratory Research; Legal patent; Licensing; Manuscripts; Massachusetts; Measures; Medical; Medical Device; Medicine; Mentors; Methods; Modeling; Monitor; Motivation; Multiple Trauma; Muscle; Nanotechnology; Natural regeneration; Nerve; Neurogenic Bladder; Ohio; Organ; Paper; Parachuting; Pelvic Floor Disorders; Pelvic floor structure; Peripheral Nerves; Physical activity; Physiology; Positioning Attribute; Prevalence; Publishing; Recovery; Reference Standards; Regenerative Medicine; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Resistance; Rodent; Role; Running; Scientific Societies; Scientist; Seeds; Services; Source; Spinal cord injury; Stress Urinary Incontinence; System; Technology; Testing; Training; Transact; Translating; Translational Research; Translations; Traumatic Brain Injury; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Urethra; Urinary Incontinence; Urology; Vagina; Veterans; Weight; Weight Lifting; Woman; career; clinical translation; college; diabetic; human subject; innovation; member; minimally invasive; nerve injury; neurotrophic factor; novel; overexpression; pelvic organ prolapse; professor; programs; regenerative; regenerative approach; rehabilitation research; research and development; research in practice; stem cells; translational potential; wireless

Summary/Abstract Dr. Margot Damaser is Senior Research Career Scientist in the RR&D Service of the US Department of Veterans Affairs and Professor of Biomedical Engineering in the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. She is Deputy Director and co-PI of the Advanced Platform Technology Center. Dr. Damaser's research is focused on using principles of engineering, physiology, and regenerative medicine to develop new models and devices for improvement of diagnosis, treatment, and rehabilitation of pelvic floor disorders (PFD): urinary incontinence, fecal incontinence, and pelvic organ prolapse. Rehabilitation of these autonomic organs is an understudied field with great relevance to Veterans, particularly women and those with spinal cord injury or neurogenic disorders. She has initiated development of novel wireless catheter- free technology for monitoring bladder and bowel function during conscious ambulation and activities of daily living. This innovative monitoring system provides a paradigm shift in diagnosis, rehabilitation, and treatment of urinary and fecal incontinence, constipation and voiding dysfunction. In addition, her research focuses on regenerative approaches to treat PFD, including stem cells and/or their secretions, electrical stimulation, and elastogenic nanotechnology. She has made significant advances in this area by demonstrating that treatment with the secretions from stem cells is highly regenerative even when the treatment is given systemically, suggesting minimal invasive therapy could be utilized. In addition, she has demonstrated that electrical stimulation can regenerate peripheral nerves even in situations of impaired regeneration. These treatments are promising to promote rehabilitation, particularly for Veterans with impaired regeneration, such as the elderly, diabetics, and those with polytrauma affecting both nerves and muscles. The over-arching goals of this research is to benefit Veterans. To that end Dr. Damaser has invested effort to translate technology and has 4 issued patents, 3 pending patents, and 1 provisional patent application, as well as 2 licensed technologies, 1 option to license a technology, 1 joint development agreement, and 1 evaluation agreement with multiple companies in the field. In 2019, Dr. Damaser was 1st Place winner for the UroMonitor in the Massachusetts Medical Device Development (M2D2) $200k Challenge, demonstrating the translational potential of her technology. She is thus on track to translate novel diagnosis, treatment and rehabilitation methods to the clinic within the next 10 years. She has obtained funding for her research from VA, NIH, DOD, the State of Ohio, and foundation and corporate sources. In recognition of the significance of her research, Dr. Damaser was elected to the American Institute for Medical and Biological Engineering (AIMBE) in 2014. During the current SRCS award period, Dr. Damaser published 37 research manuscripts, 19 review papers and 4 book chapters. She co-edited a book that has become a standard reference in the field and mentored many young investigators. Dr. Damaser is currently Deputy Director and co-PI of the Advanced Platform Technology Center (2 I50 RX001871), PI of an NIH R21 grant, (R21HD095234), PI of an NIH Other Transaction Award (NIH OT2 OD023873), and co- Investigator on multiple NIH and foundation grants. She served for 12 years as Chair of the local IACUC (2008- 2020) and serves as a member of the Field Advisory Committee to VA ORO in addition to serving on multiple VA and NIH grant review panels. In addition, she uses her research program to train many clinical, scientific, and engineering trainees in research practices, enlarging the impact of her research. In recognition of this effort, Dr. Damaser was awarded the Urology Care Foundation Distinguished Mentor Award in 2020. In her role as co-PI and Deputy Director of the APT Center, Dr. Damaser is in a position to expand her influence to mentor others in conducting productive translational rehabilitation research and development during the upcoming renewal period of her Senior Research Career Scientist Award.

摘要/摘要 玛戈特·达马泽博士是美国国防部RR&D服务的高级研究职业科学家 退伍军人事务部，克利夫兰临床勒纳医学院生物医学工程教授 凯斯西储大学。她是高级平台技术公司的副总监兼联席PI 中心。达马尔博士的研究重点是利用工程学、生理学和再生的原理 医学将开发新的模式和设备，以改进诊断、治疗和康复 盆底疾病(PFD)：尿失禁、大便失禁和盆腔器官脱垂。复康 这些自主神经器官是一个研究不足的领域，与退伍军人，特别是妇女和 那些有脊髓损伤或神经源性疾病的人。她发起了新型无线导管的开发- 有意识行走和日常活动中监测膀胱和肠道功能的免费技术 活着。这一创新的监测系统提供了诊断、康复和治疗的范式转变 大小便失禁、便秘和排尿功能障碍。此外，她的研究重点是 治疗PFD的再生方法，包括干细胞和/或其分泌物、电刺激和 弹性纳米技术。她在这一领域取得了重大进展，证明了治疗 干细胞的分泌物具有高度的再生性，即使是在系统治疗的情况下， 提示可以采用微创治疗。此外，她还展示了电学 刺激可以再生周围神经，即使在再生受损的情况下也是如此。这些治疗方法是 承诺促进康复，特别是老年人等再生能力受损的退伍军人， 糖尿病患者，以及同时影响神经和肌肉的多发性创伤患者。这项研究的总体目标是 是为了让退伍军人受益。为此，达马瑟博士投入了大量精力来翻译技术，并发布了4份 专利、3项正在申请的专利和1项临时专利申请，以及2项许可技术，1个选项 一项技术许可，1项联合开发协议，1项与多家公司的评估协议 田野。2019年，Damaser博士在马萨诸塞州医学会的UroMonitor中获得第一名 设备开发(M2D2)20万美元的挑战，展示了她的技术的翻译潜力。 因此，她正在将新的诊断、治疗和康复方法转化为 接下来的10年。她的研究得到了退伍军人事务部、美国国立卫生研究院、美国国防部、俄亥俄州和基金会的资助 和公司消息来源。由于认识到她的研究的重要性，达马泽博士被选为 美国医学和生物工程学会(AIMBE)于2014年成立。在当前的SRCS奖项期间 在此期间，Damaser博士发表了37篇研究手稿、19篇综述论文和4个书的章节。她是联合编辑 这本书已经成为该领域的标准参考，并指导了许多年轻的调查人员。达马尔博士 现任高级平台技术中心副主任兼联席PI(2 I50 RX001871)， NIH R21奖励，(R21HD095234)，NIH其他交易奖PI(NIH OT2 OD023873)，以及联合- 多项国立卫生研究院和基金会拨款的调查员。她担任了12年的地方IACUC主席(2008- 2020)，并担任退伍军人事务部外地咨询委员会成员，此外还在 弗吉尼亚州和美国国立卫生研究院拨款审查小组。此外，她利用自己的研究项目培训了许多临床、科学、 和工程实习生在研究实践中，放大了她的研究影响。为表彰这一努力， Damaser博士在2020年被授予泌尿外科护理基金会杰出导师奖。在她的角色中 作为APT中心的联席PI和副主任，Damaser博士能够将她的影响力扩大到Mentor 其他正在进行富有成效的翻译康复研究和开发 她的高级研究职业科学家奖的续发期。