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Bronchoscope-guided microwave ablation of early-stage lung tumors

支气管镜引导下早期肺部肿瘤微波消融

基本信息

批准号：
10312004
负责人：
Punit Prakash
金额：
$ 20.09万
依托单位：
KANSAS STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10312004
关键词：
Ablation Address Animal Model Animals British Columbia Bronchoscopes Bronchoscopy Clinical Clinical Research Computer Models Coupled Data Deposition Development Devices Ensure Environment Evaluation Feedback Goals Growth Heating Human Incineration Industrialization Industry Interstitial Lung Diseases Kansas Kidney Liver Lung Lung Neoplasms Lung diseases Machine Learning Malignant neoplasm of lung Medical Modality Monitor Nodule Non-Small-Cell Lung Carcinoma Nonionizing Radiation Operative Surgical Procedures Organ Outcome Patients Pattern Physicians Pilot Projects Pneumothorax Positioning Attribute Procedures Pulmonary Emphysema Radiation therapy Research Research Support Risk Safety Survival Rate System Techniques Technology Thermal Ablation Therapy Time Tissues Toxic effect Translating Translational Research Translations Treatment Efficacy Treatment outcome Universities Unresectable Work animal data base computerized cost cost effective cost effective treatment design effective therapy efficacious treatment efficacy outcomes electric impedance experience experimental study first-in-human flexibility image guided improved in vivo innovation lung preservation microwave ablation microwave electromagnetic radiation minimal risk minimally invasive novel optimal treatments pre-clinical pulmonary function real time monitoring safety and feasibility simulation tool treatment planning tumor tumor ablation virtual

项目摘要

PROJECT SUMMARY In this Industry-Academic partnership R01 research plan, we propose the development, optimization, and pilot first-in-human evaluation of a bronchoscope-guided microwave ablation (MWA) system for rapid and conformal thermal ablation of early stage pulmonary tumors. Minimally-invasive, image- guided MWA is a cost-effective treatment for thermal destruction of unresectable tumors in the liver, lung, kidney, and other organs. Current MWA technology for pulmonary tumors is limited to a percutaneous approach, which precludes treatment of central tumors and has a high associated risk of pneumothorax. Furthermore, limited intra-procedural feedback and lack of guidance and treatment planning tools places a substantial burden on the physician to precisely position applicators and ensure adequate ablation of the target, while limiting damage to non-targets. Virtual bronchoscopy and navigation, pioneered by Broncus Medical (industrial partner), affords accurate, minimally-invasive access to early-stage pulmonary tumors, with minimal risk of pneumothorax, compared to a percutaneous approach. The team at Kansas State University (academic partner) will develop optimized flexible microwave applicators for delivering localized thermal ablation to pulmonary tumors via a bronchoscopic approach. The proposed MWA devices include antennas with directional control of microwave power deposition for precise ablation of small targets, and will be extensively evaluated with computational models and experimentally, on the benchtop, and in an in vivo animal model. Transient changes in antenna impedance matching will be exploited as a feedback parameter for assessing ablation progress. A machine-learning based treatment planning and guidance platform will be developed and integrated with Broncus’ Archimedes planning and virtual bronchoscopy platform to guide the selection of optimal treatment parameters. The integrated system will be translated for first-in- human studies to evaluate the feasibility and safety of bronchoscopically delivering MWA for targeting pulmonary tumors (subaward with University of British Columbia, through Broncus Medical). The central hypothesis of this research is that a bronchoscopic MWA system integrating: (1) applicators with directional control of ablation profiles; (2) impedance-based intra-procedural feedback; and (3) bronchoscopic guidance and treatment planning tools, will afford the safe and effective treatment of localized early-stage pulmonary tumors. The proposed research will lead to the development of an integrated system for bronchoscopic ablation of pulmonary tumors, and its pilot feasibility assessment in human patients. If successful, this work will considerably expand the range of patients with lung tumors that can be treated with a cost-effective, minimally-invasive approach.

项目总结