Treating Primary aldosteronism-induced hypertension via microwave thermal therapy

微波热疗治疗原发性醛固酮增多症高血压

基本信息

  • 批准号:
    10320833
  • 负责人:
  • 金额:
    $ 33.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-02-04 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY In this tripartite US-Ireland R&D partnership program R01 research plan, we propose the development, optimization, and evaluation of a minimally-invasive microwave thermal therapy (MWT) system for definitive treatment of primary aldosteronism. Primary aldosteronism (PA) accounts for 5 - 12% of all hypertension and confers a higher risk for cardiovascular and cerebrovascular complications compared to age and blood pressure (BP) matched essential hypertension. Yet PA remains under-diagnosed and under-treated, largely due to the lack of definitive management options for the majority of affected individuals. The current definitive approach to unilateral PA is surgical adrenalectomy, while bilateral disease is managed medically; medical therapy is often poorly tolerated due to off target anti-androgen effects. Only ~30% of all individuals diagnosed with PA undergo surgery, and collateral resection of normal cortex limits the option of surgery to unilateral disease, given the inevitable risk for adrenocortical insufficiency with bilateral adrenalectomy. Therefore, the overall objective of this proposal is the development, optimization, and experimental evaluation of an image-guided approach for sub-ablative MWT of APAs, and for post-treatment assessment of adrenal function. First, we will employ a series of in vitro studies to determine the optimal range of thermal doses for rendering hyperfunctioning adrenal cells defunct, at sub-ablative thermal doses. We will then verify the ability to disrupt adrenal cell function at these thermal doses in an in vivo mouse tumor model, with thermal dose tracked via MRI temperature imaging. Next, we will develop a system employing microwave applicators with precise spatio-temporal control of microwave radiation to deliver MWT to hyperfunctioning adrenal cells. We will develop real-time techniques for identifying the targeted tissue from real-time imaging, informed by pre-procedural PET/CT imaging localizing the hyperfunctioning adrenal cells, in order to guide applicator placement and energy delivery. Finally, we will develop a non-iodinated contrast agent suitable for verifying adrenal cell function, immediately post MWT, thereby providing a means for assessing treatment outcome. The overall system will be evaluated in a large animal model. If successful, and translated to humans in future studies, this approach will, for the first time, extend definitive management of PA to individuals with unilateral and bilateral APAs. !
项目摘要 在这个美国-爱尔兰三方研发伙伴关系计划R 01研究计划中,我们提出开发, 优化和评估微创微波热治疗(MWT)系统, 原发性醛固酮增多症的确定性治疗。原发性醛固酮增多症(PA)占所有患者的5 - 12%。 高血压,并赋予更高的风险,心血管和脑血管并发症相比, 年龄和血压(BP)匹配的原发性高血压。然而,PA仍然诊断不足, 治疗不足,主要原因是大多数受影响者缺乏明确的管理选择 个体目前单侧PA的确定方法是手术切除肾上腺,而双侧PA则是手术切除肾上腺。 疾病通过药物管理;由于脱靶抗雄激素,药物治疗通常耐受性差 方面的影响.在所有确诊为PA的患者中,只有约30%接受了手术, 正常的皮质限制了单侧疾病的手术选择, 肾上腺皮质功能不全伴双侧肾上腺切除术因此,这一总体目标 一项提案是图像引导方法的开发、优化和实验评估 用于APA的亚消融MWT和肾上腺功能的治疗后评估。一是 采用一系列体外研究来确定用于渲染的最佳热剂量范围 功能亢进的肾上腺细胞在亚消融热剂量下死亡。然后我们将验证 在体内小鼠肿瘤模型中,在这些热剂量下破坏肾上腺细胞功能, 通过核磁共振温度成像追踪。接下来,我们将开发一个系统, 通过精确的微波辐射时空控制将MWT输送到功能亢进的肾上腺 细胞我们将开发实时技术,从实时成像中识别目标组织, 通过术前PET/CT成像定位功能亢进的肾上腺细胞, 引导施用器放置和能量输送。最后,我们将开发一种非碘化造影剂 适合于在MWT后立即验证肾上腺细胞功能,从而提供了一种方法, 评估治疗结果。将在大型动物模型中评价整个系统。如果 成功,并在未来的研究中转化为人类,这种方法将首次扩展到 对单侧和双侧APA患者进行明确的PA管理。 !

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Punit Prakash其他文献

Punit Prakash的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Punit Prakash', 18)}}的其他基金

Treating Primary aldosteronism-induced hypertension via microwave thermal therapy
微波热疗治疗原发性醛固酮增多症高血压
  • 批准号:
    10552540
  • 财政年份:
    2020
  • 资助金额:
    $ 33.07万
  • 项目类别:
Bronchoscope-guided microwave ablation of early-stage lung tumors
支气管镜引导下早期肺部肿瘤微波消融
  • 批准号:
    10065497
  • 财政年份:
    2018
  • 资助金额:
    $ 33.07万
  • 项目类别:
Bronchoscope-guided microwave ablation of early-stage lung tumors
支气管镜引导下早期肺部肿瘤微波消融
  • 批准号:
    10312004
  • 财政年份:
    2018
  • 资助金额:
    $ 33.07万
  • 项目类别:

相似海外基金

The role of ZNRF3/Znrf3 exon2 deletion on zonation and maintenance of the adrenal cortex
ZNRF3/Znrf3 外显子 2 缺失对肾上腺皮质分区和维持的作用
  • 批准号:
    22K08680
  • 财政年份:
    2022
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Investigation of the role of proinsulin-positive bone marrow-derived cells appearing in the adrenal cortex
研究肾上腺皮质中出现的胰岛素原阳性骨髓来源细胞的作用
  • 批准号:
    21K07338
  • 财政年份:
    2021
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The contribution of capsular and subcapsular progenitor cells in homeostatic adrenal cortex self-renewal and zonal-specific remodelling.
被膜和被膜下祖细胞在稳态肾上腺皮质自我更新和区域特异性重塑中的贡献。
  • 批准号:
    BB/V007246/1
  • 财政年份:
    2021
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Research Grant
Elucidating and modelling complex postnatal steroid hormone changes in preterm infants: insights into the developing immature neonatal adrenal cortex
阐明和模拟早产儿复杂的产后类固醇激素变化:深入了解发育中的未成熟新生儿肾上腺皮质
  • 批准号:
    MR/V037757/1
  • 财政年份:
    2021
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Research Grant
Role of the BMP system and effect on blood pressure regulation in the adrenal cortex
BMP 系统的作用及其对肾上腺皮质血压调节的影响
  • 批准号:
    20K17512
  • 财政年份:
    2020
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Elucidation of the mechanism establishing sex difference in adrenal cortex cell proliferation by sex hormones
阐明性激素在肾上腺皮质细胞增殖中建立性别差异的机制
  • 批准号:
    20K08863
  • 财政年份:
    2020
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Regulation of sexually dimorphic functions of adrenal cortex by sex chromosomes
性染色体对肾上腺皮质性二态性功能的调节
  • 批准号:
    20H03436
  • 财政年份:
    2020
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Identifying a role of delta-5 steroids from adrenal cortex for development of adrenal medulla
确定肾上腺皮质 delta-5 类固醇对肾上腺髓质发育的作用
  • 批准号:
    25860764
  • 财政年份:
    2013
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The production mechanism and role of progesterone in female mouse adrenal cortex.
雌性小鼠肾上腺皮质孕酮的产生机制及其作用。
  • 批准号:
    22591015
  • 财政年份:
    2010
  • 资助金额:
    $ 33.07万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular regulation of adrenal cortex homeostasis and remodeling
肾上腺皮质稳态和重塑的分子调节
  • 批准号:
    7897654
  • 财政年份:
    2009
  • 资助金额:
    $ 33.07万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了