Advances in Musculoskeletal & Neuronal Interactions

肌肉骨骼的进展

• 批准号: 10318837
• 负责人: HICHAM M DRISSI
• 金额: $ 5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318837
• 关键词: Address; Administrator; Age; Aging; Area; Atrophic; Award; Biology; Biology of Aging; Bone Tissue; COVID-19; Cells; Clinical Research; Collaborations; Communication; Communities; Congresses; Development; Discipline; Disease; Elderly; Etiology; Event; Financial Hardship; Fracture; Funding Opportunities; Goals; Hip Fractures; Hospitalization; Impairment; Incidence; Indiana; Injury; Longevity; Mechanics; Morbidity - disease rate; Muscle; Muscle Weakness; Muscle satellite cell; Muscular Atrophy; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Myocardial Infarction; Natural regeneration; Neuromuscular Junction; Neurons; ORALIT; Oral; Osteoporosis; Persons; Population; Prevention strategy; Public Health; Publications; Quality of life; Regenerative Medicine; Research; Research Personnel; Role; Schedule; Scientist; Stroke; Structure; Technology; Time; Tissue Engineering; Tissues; Translational Research; Travel; Underrepresented Populations; United States; United States National Institutes of Health; Universities; Work; age related; bone; bone aging; bone mass; cellular imaging; cost; design; falls; healthspan; interest; malignant breast neoplasm; meetings; muscle aging; muscle form; muscle regeneration; new therapeutic target; novel strategies; osteoporosis with pathological fracture; posters; posture instability; programs; repaired; stem; stem cells; symposium; tissue regeneration; treatment strategy; virtual; web site

The public health burden of age-related diseases is increasing rapidly as the number of older adults continues to rise. Osteoporotic fractures are now responsible for more hospitalizations in the United States than heart attack, stroke, and breast cancer combined. Muscle weakness and postural instability are major contributors to the incidence of falls among the elderly, and falling is the primary etiological factor in 90% of hip fractures. Loss of muscle and bone mass with age is therefore a major limiting factor on health span, as the morbidity that accompanies fractures in the elderly is costly both in terms of financial burden and quality of life. A major gap in the advancement of new prevention and treatment strategies for age-related musculoskeletal diseases is a lack of integration from various areas of musculoskeletal research. Our goal is to bring together leaders from these various disciplines to facilitate communication, identify future research directions, and attract young scientists to this emerging, interdisciplinary area of research. The proposed 2021 meeting “Advances in Musculoskeletal & Neuronal Interactions” in Atlanta will include i) a focus on stem biology in muscle and bone, and the role(s) of these cell populations in musculoskeletal crosstalk, ii) new advances in neuromuscular junction structure, function and degradation in aging, iii) tissue engineering approaches for musculoskeletal repair and regeneration, and iv) novel approaches for cellular imaging of muscle and bone tissue. Aim 1 is to bring together research leaders to stimulate new collaborative studies in the area of musculoskeletal and neuronal interactions with an emphasis on age-related impairment. Aim 2 is to inspire new ideas through brainstorming sessions, group discussions, panel discussions, and one-on-one interactions. Aim 3 is to identify means to promote, inform, and support the emerging field of musculoskeletal & neuronal interactions. Aim 4 is to disseminate information regarding such interactions and age-relatedness including latest ideas, state-of-the-art technologies, potential for collaboration, and new opportunities for funding and support. We believe this program reflects the most exciting advances relevant to the fields of aging biology, muscle, bone and neuronal interactions and will serve as the platform to identify promising opportunities and future research directions.

随着老年人数量的持续增加，与年龄有关的疾病造成的公共卫生负担正在迅速增加 站起来。在美国，骨质疏松性骨折导致的住院人数超过了心脏病 发作、中风和乳腺癌加在一起。肌肉无力和姿势不稳是导致 老年人跌倒的发生率较高，跌倒是90%髋部骨折的主要病因。损失 因此，肌肉和骨量随年龄增长是健康寿命的主要限制因素，因为 在老年人中伴随骨折在经济负担和生活质量方面都是昂贵的。在以下方面存在重大差距 缺乏针对年龄相关性肌肉骨骼疾病的新的预防和治疗策略 从肌肉骨骼研究的不同领域进行整合。我们的目标是将这些国家的领导人聚集在一起 各学科促进交流，确定未来研究方向，吸引青年科学家 这一新兴的跨学科研究领域。拟于2021年举行的“肌肉骨骼与研究进展”会议 在亚特兰大举行的《神经元相互作用》将包括：i)重点介绍肌肉和骨骼的干细胞生物学，以及S的作用 这些细胞群在肌肉骨骼相声中，II)神经肌肉连接结构的新进展， 衰老中的功能和退化，III)肌肉骨骼修复和组织工程方法 再生，以及iv)肌肉和骨组织细胞成像的新方法。目标1是将 研究带头人推动肌肉骨骼和神经元相互作用领域的新合作研究 重点是与年龄相关的损害。目标2是通过集思广益会议激发新想法， 小组讨论、小组讨论和一对一互动。目标3是确定促进、告知、 并支持肌肉骨骼和神经元相互作用这一新兴领域。目标4是传播信息 关于这种互动和与年龄的联系，包括最新的想法、最先进的技术、潜在的 合作，以及获得资金和支持的新机会。我们认为这个节目最能反映 与衰老生物学、肌肉、骨骼和神经元相互作用相关的令人兴奋的进展，并将服务于 作为发现有希望的机会和未来研究方向的平台。