Advances in Musculoskeletal & Neuronal Interactions

肌肉骨骼的进展

• 批准号: 10318837
• 负责人: HICHAM M DRISSI
• 金额: $ 5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318837
• 关键词: Address; Administrator; Age; Aging; Area; Atrophic; Award; Biology; Biology of Aging; Bone Tissue; COVID-19; Cells; Clinical Research; Collaborations; Communication; Communities; Congresses; Development; Discipline; Disease; Elderly; Etiology; Event; Financial Hardship; Fracture; Funding Opportunities; Goals; Hip Fractures; Hospitalization; Impairment; Incidence; Indiana; Injury; Longevity; Mechanics; Morbidity - disease rate; Muscle; Muscle Weakness; Muscle satellite cell; Muscular Atrophy; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Myocardial Infarction; Natural regeneration; Neuromuscular Junction; Neurons; ORALIT; Oral; Osteoporosis; Persons; Population; Prevention strategy; Public Health; Publications; Quality of life; Regenerative Medicine; Research; Research Personnel; Role; Schedule; Scientist; Stroke; Structure; Technology; Time; Tissue Engineering; Tissues; Translational Research; Travel; Underrepresented Populations; United States; United States National Institutes of Health; Universities; Work; age related; bone; bone aging; bone mass; cellular imaging; cost; design; falls; healthspan; interest; malignant breast neoplasm; meetings; muscle aging; muscle form; muscle regeneration; new therapeutic target; novel strategies; osteoporosis with pathological fracture; posters; posture instability; programs; repaired; stem; stem cells; symposium; tissue regeneration; treatment strategy; virtual; web site

The public health burden of age-related diseases is increasing rapidly as the number of older adults continues to rise. Osteoporotic fractures are now responsible for more hospitalizations in the United States than heart attack, stroke, and breast cancer combined. Muscle weakness and postural instability are major contributors to the incidence of falls among the elderly, and falling is the primary etiological factor in 90% of hip fractures. Loss of muscle and bone mass with age is therefore a major limiting factor on health span, as the morbidity that accompanies fractures in the elderly is costly both in terms of financial burden and quality of life. A major gap in the advancement of new prevention and treatment strategies for age-related musculoskeletal diseases is a lack of integration from various areas of musculoskeletal research. Our goal is to bring together leaders from these various disciplines to facilitate communication, identify future research directions, and attract young scientists to this emerging, interdisciplinary area of research. The proposed 2021 meeting “Advances in Musculoskeletal & Neuronal Interactions” in Atlanta will include i) a focus on stem biology in muscle and bone, and the role(s) of these cell populations in musculoskeletal crosstalk, ii) new advances in neuromuscular junction structure, function and degradation in aging, iii) tissue engineering approaches for musculoskeletal repair and regeneration, and iv) novel approaches for cellular imaging of muscle and bone tissue. Aim 1 is to bring together research leaders to stimulate new collaborative studies in the area of musculoskeletal and neuronal interactions with an emphasis on age-related impairment. Aim 2 is to inspire new ideas through brainstorming sessions, group discussions, panel discussions, and one-on-one interactions. Aim 3 is to identify means to promote, inform, and support the emerging field of musculoskeletal & neuronal interactions. Aim 4 is to disseminate information regarding such interactions and age-relatedness including latest ideas, state-of-the-art technologies, potential for collaboration, and new opportunities for funding and support. We believe this program reflects the most exciting advances relevant to the fields of aging biology, muscle, bone and neuronal interactions and will serve as the platform to identify promising opportunities and future research directions.

随着老年人的数量继续，与年龄相关疾病的公共卫生烧伤正在迅速增加 上升。骨质疏松性骨折现在负责美国的住院时间多于心脏 攻击，中风和乳腺癌的总和。肌肉无力和姿势不稳定是主要的贡献者 在髋部骨折的90％中，跌落和下降的跌落和下降的事件是病因。损失 因此 在财务燃烧和生活质量方面，伴随着骨折的骨折是昂贵的。一个主要差距 缺乏与年龄有关的肌肉骨骼疾病的新预防和治疗策略的发展 肌肉骨骼研究各个领域的整合。我们的目标是将领导者从这些 各种学科，以促进沟通，确定未来的研究方向，并吸引年轻科学家 这个新兴的研究领域。拟议的2021会议会议“肌肉骨骼的进步 亚特兰大的神经元相互作用”将包括i）关注肌肉和骨骼中的茎生物学，以及 这些细胞群体中的肌肉骨骼串扰，ii）神经肌肉连接结构的新进展， 衰老的功能和降解，iii）肌肉骨骼修复的组织工程方法 再生和IV）肌肉和骨组织细胞成像的新方法。目标1是聚在一起 研究领导者刺激肌肉骨骼和神经元相互作用领域的新协作研究 强调与年龄有关的障碍。 AIM 2是通过集思广益会议激发新想法， 小组讨论，小组讨论和一对一的互动。目标3是确定促进，告知， 并支持肌肉骨骼和神经元相互作用的新兴领域。目标4是传播信息 关于此类互动和与年龄有关的性，包括最新想法，最先进的技术，潜在的 合作以及新的资金和支持机会。我们相信该计划最反映 令人兴奋的相对于衰老生物学，肌肉，骨骼和神经元相互作用的领域的令人兴奋的进步，并将服务 作为确定许可机会和未来研究方向的平台。