RR&D Research Career Scientist Award Application

RR

• 批准号: 10317820
• 负责人: DUSTIN J. TYLER
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10317820
• 关键词: Action Potentials; Address; Advanced Development; Animal Experimentation; Area; Award; Baroreflex; Biomedical Engineering; Blood Pressure; Bluetooth; Brain; Chronic; Clinical; Clinical Research; Clupeidae; Collaborations; Colorado; Complex; Computational algorithm; Dermis; Development; Devices; Disease; Doctor of Philosophy; Electrical Engineering; Electrodes; Electromagnetics; Elements; Emotional; Engineering; Esthesia; Eye; Florida; Funding; Goals; Government; Grant; Hand; Health; Heart Rate; Histologic; Human; Hypertension; Implant; Individual; Industry; Injections; Institution; Limb structure; Love; Lower Extremity; Medical center; Mentors; Methods; Michigan; Mission; Modeling; Movement; Muscle; Nerve; Nervous system structure; Neurologic Deficit; Neurosciences; Paper; Paralysed; Paraplegia; Patients; Pattern; Perception; Peripheral; Peripheral Nerve Stimulation; Peripheral Nerves; Peripheral Nervous System; Pharmaceutical Preparations; Pharmacologic Substance; Polymers; Privatization; Prostheses and Implants; Prosthesis; Quadriplegia; Quality of life; Randomized Clinical Trials; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Role; Science; Scientist; Sea Cucumbers; Secure; Seminal; Sensory; Services; Specialist; Spinal cord injury; Stimulus; Stroke; System; Talents; Techniques; Technology; Thinking; Tissues; Touch sensation; Translational Research; Translations; Upper Extremity; Veterans; Walking; Wife; Work; blood pressure regulation; career; career development; carotid sinus; clinical translation; computational neuroscience; density; design; experience; fascinate; foot; functional restoration; hypertension control; implantation; improved; indexing; interest; limb loss; multidisciplinary; nanocomposite; nervous system disorder; neural implant; neuroregulation; next generation; preclinical development; professor; programs; relating to nervous system; response; restoration; sensory feedback; skills; technology development

“… to feel my wife’s hand,” he said with tears in his eyes. This was our subject’s response when he was asked what he wanted to get from participating in our study. His five simple words brought a tectonic shift in my thinking and provided the deep purpose to my work. Patient’s do not need fancy technology. They need to feel whole. They need to be connected. As a neural engineer, I develop neural interface technology that connects to humans. Three additional words are needed to capture my passion and over-arching goal as a VA Research Career Scientist: I develop nerve interface technology that connects to humans to connect humans. For nearly thirty years, I have combined a love for electrical engineering (B.S.E.E., 1992, Michigan Technological Univ, Houghton, MI) and computation algorithms with fascination of the brain and neuroscience to develop technology for communicating directly with the human nervous system (Ph.D. Biomedical Engineering, 1999, Case Western Reserve Univ, Cleveland, OH). I am one of the world’s top experts in development and translation of systems to precisely apply small electrical current injections to nerves to cause targeted action potentials in nerves. Early in my career, I used this technology to restore lost function following stroke or paralysis by activating muscles. I still actively collaborate with other VA investigators (Drs. Ronald Triolo, Gilles Pinault, Bolu Ajiboye, Emily Graczyk, and Robert Kirsch) in a supporting role to implement neural interface technology in clinical rehabilitation programs for spinal cord injury. A decade ago, however, I became much more interested in the power of the technology to communicate to the brain through sensory and autonomic systems. My VA activity fits into three area: 1) sensory technology for veterans with limb loss; 2) hypertension control in veterans that have not been responsive to medications, and 3) development of advances in peripheral nerve interface technology. Sensory Technology restores both functional and emotional connection following limb loss of the upper extremity (with Drs. J. Robert Anderson, Kevin Malone, Kyle Chepla, and Emily Graczyk) and lower extremity (with Drs. Ronald Triolo, Gilles Pinault, and Hamid Chakhkar). My lab in the Cleveland VA Medical Center is the first in the world to have a long-term implant of a peripheral interfaces for sensory restoration following limb loss. Eight subjects, four with upper extremity and four with lower extremity limb loss, have been implanted. Over the past four years, I have led a program funded by both the VA and the Defense Advance Research Projects Agency to develop a fully implantable, Bluetooth®-connected system for bi-directional connection between and external prosthesis and implanted interfaces. My team has secured all necessary regulatory approvals to start the world’s first randomized clinical trial (RCT) of neural-connected advanced prostheses. Over the next four years, this study will complete a critical step in moving the technology to general availability for all veterans with limb loss. Hyptertension: Neural interface technology is applied to modulate function of complex regulation of blood pressure. In individuals that are unresponsive to pharmaceutical approaches, we control hypertension through the baroreflex via activation of the carotid sinus nerve (CSN or Herring’s nerve) (with Drs. Jonathan Baskin, Gilles Pinault, and Elizabeth Heald). The work is in collaboration with a commercial partner to rapidly advance the technology benefit veterans within the next five years. Advancing Interfaces: To continue advancing the clinical capabilities of neural interfaces, advances in technology are continually needed. I continue pre-clinical development and translation of next generation of peripheral nerve technology. This includes increasing the number of channels on each electrode and the distribution of the contact throughout the nerve. This includes collaboration with MEMS fabrication specialist in the Cleveland VA (Dr. Douglas Shire) and Lawrence Livermore National Lab (Dr. Razi Haque) to develop high-density FINE and interfascicular nerve electrodes, implantation techniques, and high-density inline connectors.

“......感受我妻子的手，”他说，眼里含着泪水。这是我们的实验对象 问他想从参与我们的研究中得到什么。他简单的五个字带来了一个结构性的转变， 我的想法，并为我的工作提供了深刻的目的。病人不需要高科技。他们需要 感觉完整。他们需要联系起来。作为一名神经工程师，我开发神经接口技术， 连接到人类。我还需要另外三个词来表达我的激情和过度追求的目标， VA研究职业科学家：我开发神经接口技术，连接到人类连接人类。 近三十年来，我结合了对电气工程的热爱（B.S.E.E.，1992年，密歇根州 技术大学，霍顿，密歇根州）和计算算法与迷恋的大脑和 神经科学开发直接与人类神经系统通信的技术（博士） 生物医学工程，1999，凯斯西储大学，克利夫兰，OH）。我是世界顶尖的专家之一 在将小电流注入精确地施加到神经的系统的开发和转化中， 在神经中产生定向动作电位。在我职业生涯的早期，我用这项技术恢复了失去的功能 中风或瘫痪后通过激活肌肉。我仍然积极地与退伍军人事务部的其他调查人员合作 (Drs.罗纳德特里奥洛，吉勒皮诺，博卢阿吉博耶，艾米丽格拉兹克，和罗伯特基尔希）在配角， 在脊髓损伤临床康复计划中实施神经接口技术。十年 然而，在此之前，我对这项技术与大脑交流的能力更感兴趣， 通过感觉和自主神经系统。我的VA活动分为三个领域：1）感官技术， 肢体丧失的退伍军人; 2）对药物无反应的退伍军人的高血压控制， 3）周围神经接口技术的发展。感官技术恢复 上肢肢体丧失后的功能和情感联系（与J.罗伯特博士 安德森、凯文马龙、凯尔切普拉和艾米丽格拉兹克）和下肢（与罗纳德特里奥洛博士， Gilles Pinault和Hamid Chakhkar）。我在克利夫兰退伍军人医疗中心的实验室是世界上第一个 在肢体丧失后进行外周界面的长期植入以恢复感觉。八 四名上肢和四名下肢肢体缺失的受试者已经被植入。来 在过去的四年里，我领导了一个由退伍军人事务部和国防部高级研究项目共同资助的项目 机构开发一种完全植入式蓝牙®连接系统，用于双向连接 以及外部假体和植入界面。我的团队已经获得了所有必要的监管批准 开始世界上第一个神经连接先进假体的随机临床试验（RCT）。来 未来四年，这项研究将完成一个关键步骤，将该技术推向一般可用性， 都是失去肢体的老兵高血压：神经接口技术应用于调节 复杂的血压调节。在对药物治疗无反应的个体中， 我们通过激活颈动脉窦神经（CSN或Herring's）的压力反射来控制高血压 神经）（与乔纳森巴斯金，吉勒皮诺和伊丽莎白希尔德博士）。这项工作是与一个 商业合作伙伴在未来五年内迅速推进这项技术，使退伍军人受益。推进 接口：为了继续推进神经接口的临床能力，技术的进步是 不断需要。我继续进行下一代周围神经的临床前开发和翻译 技术.这包括增加每个电极上的通道的数量和电极的分布。 接触整个神经。这包括与克利夫兰的MEMS制造专家合作 弗吉尼亚州（道格拉斯夏尔博士）和劳伦斯利弗莫尔国家实验室（拉齐哈克博士）开发高密度 精细和束间神经电极、植入技术和高密度内联连接器。