Peripheral Interfaces in Amputees to Restore Sensation

截肢者恢复感觉的外围接口

基本信息

项目摘要

DESCRIPTION (provided by applicant): Our hands are the primary means by which we explore and manipulate our environment. They perform thousands of intricate movements without conscious thought or even visual attention. Sensory feedback is a critical element of these complex activities. Lack of sensory feedback in myoelectric upper limb prostheses makes fluid and complex motions difficult and requires the user to maintain visual attention on the prosthesis to perform even the simplest task. In this project, we will address the need for sensory feedback by implanting non-penetrating cuff electrodes on the residual upper limb nerves. Our central hypothesis is that direct nerve stimulation with selective, non-penetrating cuff electrodes on the residual upper limb nerves can elicit graded sensation and proprioception at multiple locations in the perceptual hand. Further, restoration of sensory feedback with cuff electrodes will reduce visual and cognitive load during prosthesis usage, improve functional performance, and result in embodiment of the prosthesis. In the first funded merit review, the electrode and stimulation technology was developed and fully prepared for clinical implementation. The FDA and local IRB approved investigation of the system in amputees under an investigational device exemption, IDE #G110043. The first subject was implanted in May of 2012. In the first subject, stimulation through 19 active contacts produced 19 unique locations of sensory perception on the subject's perceptual hand. The locations of the perception and the stimulation parameters continue to remain stable, which is more than six month at time of this proposal submission. Further, by modulating stimulation patterns, several perceptions can be produced at each location on the phantom, including pressure, slip, tingling, and pricking. We have, for the first time, shown peripheral nerve stimulation produces highly selective, stable, and normal sensory perception in many places on the phantom of the person with limb loss. The purpose of this project is to study these results in a full cohort of five subjects, demonstrate home use of sensory feedback, and demonstrate improved usage and sense of embodiment resulting from natural sensory feedback. We have a strong working relationship with Otto Bock and Hanger Clinic, providing a solid team poised to make a significant and real impact on veterans, wounded warriors, and the upper limb loss community, as a whole. Specifically, the aims for this project are: Aim 1: Characterize sensory perception. Upper extremity peripheral nerve stimulation elicits graded sensory perceptions in more than one location on the phantom limb and the perceptions are stable up to at least two years. Aim 2: Demonstrate functional improvement. Stable sensory perception elicited by cuff electrodes will reduce attention and visual load required for adequate prosthesis control and will improve functional performance. Aim 3: Demonstrate embodiment. Stable sensory perception elicited by cuff electrodes in synchrony with physical stimuli applied to the artificial limb will result in embodiment of the artificial limb. Aim 4: Design and verify an implantable stimulator for permanent sensory restoration. To reach a larger population, a fully implanted system will be required. While it is premature for investment in a fully implanted device, the stimulation circuity will be developed in a bench-top system to prepare for future implant development. In collaboration with Otto Bock, the Michelangelo AxonBus hand and wrist system will be our prosthesis development platform. Collaboration with Hanger Clinic will provide valuable patient-centric guidance and access to a substantial candidate pool. Following successful execution of the work proposed, we expect to show permanent improvement in upper limb prosthesis performance and user embodiment due to permanent, natural sensory feedback through peripheral nerves.
描述(由申请人提供): 我们的手是我们探索和操纵环境的主要手段。他们在没有意识思考甚至没有视觉注意的情况下完成数千个复杂的动作。感官反馈是这些复杂活动的关键要素。在肌电上肢假肢中缺乏感觉反馈使得流畅和复杂的运动变得困难,并且需要用户保持对假肢的视觉注意力以执行甚至最简单的任务。在这个项目中,我们将通过在上肢残端神经上植入非穿透性袖带电极来解决感觉反馈的需要。我们的中心假设是,直接神经刺激与选择性的,非穿透袖带电极上的残余上肢神经可以引起分级的感觉和本体感觉在多个位置的知觉手。此外,用袖带电极恢复感觉反馈将减少假体使用期间的视觉和认知负荷,改善功能性能,并导致假体的具体化。在第一次受资助的价值审查中,电极和刺激技术得到开发,并为临床实施做好了充分准备。FDA和当地IRB根据试验用器械豁免(IDE #G110043)批准了在截肢者中对该系统进行的研究。首例受试者于2012年5月植入。在第一个主题中,通过19个主动接触的刺激产生了19个独特的位置的感官知觉的主体的感知的手。感知位置和刺激参数继续保持稳定,在提交本提案时已超过六个月。此外,通过调节刺激模式,可以在体模上的每个位置处产生若干感知,包括压力、滑动、刺痛和刺痛。我们第一次证明了周围神经刺激在肢体丧失患者的幻肢上的许多地方产生高度选择性、稳定和正常的感觉知觉。这个项目的目的是研究这些结果在一个完整的队列的五个科目,展示家庭使用的感觉反馈,并证明改进的使用和感觉的体现,从自然的感觉反馈。我们与Otto Bock和Hanger Clinic建立了牢固的工作关系,提供了一个坚实的团队,准备对退伍军人,受伤的战士和上肢损失社区产生重大而真实的影响。具体而言,该项目的目标是:目标1:表征感官知觉。上肢周围神经刺激可使幻肢上多个部位的感觉分级,并且这些感觉至少在两年内保持稳定。目标2:展示功能改进。由袖带电极引起的稳定的感官知觉将减少足够的假体控制所需的注意力和视觉负荷,并将改善功能性能。目标3:展示具体化。由袖带电极引起的与施加到假肢的物理刺激同步的稳定的感官知觉将导致假肢的具体化。目的4:设计和验证植入式刺激器, 永久性的感官恢复为了达到更大的人群,将需要完全植入的系统。虽然投资于完全植入式器械还为时过早,但将在台式系统中开发刺激电路,为未来的植入物开发做准备。与Otto Bock合作,Michelangelo AxonBus手部和手腕系统将成为我们的假肢开发平台。与Hanger Clinic的合作将提供有价值的以患者为中心的指导,并获得大量的候选人。在成功执行所提出的工作后,我们希望通过外周神经的永久性、自然的感觉反馈,显示上肢假肢性能和用户体现的永久性改善。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DUSTIN J. TYLER其他文献

DUSTIN J. TYLER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DUSTIN J. TYLER', 18)}}的其他基金

RR&D Research Career Scientist Award Application
RR
  • 批准号:
    10317820
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Peripheral Interfaces in Amputees for Sensorimotor Integration
截肢者的感觉运动整合外设接口
  • 批准号:
    10230986
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Peripheral Interfaces in Amputees for Sensorimotor Integration
截肢者的感觉运动整合外设接口
  • 批准号:
    10557779
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Peripheral Interfaces in Amputees to Restore Sensation
截肢者恢复感觉的外围接口
  • 批准号:
    8679828
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Peripheral Interfaces in Amputees to Restore Sensation
截肢者恢复感觉的外围接口
  • 批准号:
    9017825
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Multi-disciplinary, Undergraduate Design Teams to Meet Healthcare Needs
多学科本科设计团队满足医疗保健需求
  • 批准号:
    8265157
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Multi-disciplinary, Undergraduate Design Teams to Meet Healthcare Needs
多学科本科设计团队满足医疗保健需求
  • 批准号:
    8494614
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Multi-disciplinary, Undergraduate Design Teams to Meet Healthcare Needs
多学科本科设计团队满足医疗保健需求
  • 批准号:
    8687493
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Multi-disciplinary, Undergraduate Design Teams to Meet Healthcare Needs
多学科本科设计团队满足医疗保健需求
  • 批准号:
    9134758
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Peripheral Nerve Implementation of Functional Neuroprostheses
功能性神经假体的周围神经实施
  • 批准号:
    7477869
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:

相似海外基金

A patient-oriented research approach to studying sex differences in the prosthetic needs and priorities of lower limb amputees
以患者为导向的研究方法,用于研究下肢截肢者的假肢需求和优先事项的性别差异
  • 批准号:
    485115
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Operating Grants
Developing a gene therapy product to treat pressure ulcers in lower-limb amputees
开发一种基因治疗产品来治疗下肢截肢者的压力性溃疡
  • 批准号:
    2888189
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Studentship
IMPILO-AI: Intelligent Monitoring of Prosthesis conditions In LOwer limb amputees - Advancing Innovation
IMPILO-AI:智能监测下肢截肢者的假肢状况 - 推进创新
  • 批准号:
    10082684
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Collaborative R&D
Development and Evaluation of a Wearable Biofeedback Gait Training System for Lower Limb Amputees
下肢截肢者可穿戴生物反馈步态训练系统的开发和评估
  • 批准号:
    568803-2022
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Engineering design optimization of a lower limb prosthesis for female single-limb transtibial amputees using a computational modelling and user-centered design approach.
使用计算建模和以用户为中心的设计方法对女性单肢跨胫截肢者的下肢假肢进行工程设计优化。
  • 批准号:
    569642-2022
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Improving the health status of dysvascular amputees by deploying digital prosthetic interface technology in combination with exercise intervention
通过部署数字假肢接口技术结合运动干预来改善血管障碍性截肢者的健康状况
  • 批准号:
    10707261
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Improving the health status of dysvascular amputees by deploying digital prosthetic interface technology in combination with exercise intervention
通过部署数字假肢接口技术结合运动干预来改善血管障碍性截肢者的健康状况
  • 批准号:
    10547407
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
A Low-Cost, Practical Fitness Monitor of Socket-Suspension Systems for Lower Limb Amputees
适用于下肢截肢者的低成本、实用的插座悬挂系统健康监测仪
  • 批准号:
    10384774
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Restoring Proprioception to Improve Balance and Gait in Lower-Limb Amputees - COVID-19 Supplement
恢复本体感觉以改善下肢截肢者的平衡和步态 - COVID-19 补充资料
  • 批准号:
    10619249
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Minimising bone mineral density loss in traumatic amputees: a randomised controlled feasibility trial
最大限度地减少创伤性截肢者的骨矿物质密度损失:一项随机对照可行性试验
  • 批准号:
    EP/X027155/1
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Fellowship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了