Neural basis of memory in primate medial temporal lobe

项目摘要 内侧颞叶（MTL）在大脑中情景记忆的快速形成中起着关键作用。 人类和非人类灵长类动物，而在自由移动的啮齿动物中进行的研究同样 将这些相同的结构确定为空间导航的关键。每一项工作 反映了强大的研究传统，这些传统极大地促进了我们对医学的理解。 颞叶功能，但问题仍然是如何协调他们的大量数据集。一 令人信服的假设是，支持MTL在空间中的作用的相同神经机制 导航也支持情景记忆的形成。我们提出了一套创新的 旨在直接验证这一假设的实验我们的方法包括记录神经活动 在两种情况下，来自绒猴内侧颞叶的相同神经元。一 涉及头部受限的受试者执行人类典型的识别记忆任务， 实验，而在其他自由移动的科目导航空间环境中常用的 在啮齿动物的研究中。我们的创新方法将使我们能够首次测试 灵长类内侧颞叶中的相同神经元支持在代表性任务中执行的行为 这两种研究传统。目的1试图用以下方法来描述绒猴的识别记忆： 一项任务，像空间导航一样，依赖于偶然的记忆形成。目标2中的实验 检查海马CA场和内嗅皮层在空间导航中的作用，包括 位置细胞和网格细胞的假定存在，分别。目标3直接测试校长 通过记录相同的神经元，而受试者执行这个建议的问题， 目标1中的识别记忆任务和导航空间环境中的研究目标2。

Project Summary The medial temporal lobe (MTL) plays a critical role in the rapid formation of episodic memories in human and nonhuman primates, while research performed in freely-moving rodents has likewise identified these same structure as being pivotal for spatial navigation. Each of these lines of work reflect powerful research traditions that have significantly contributed to our understanding of medial temporal lobe function, but questions remain about how to reconcile their considerable data sets. One compelling hypothesis is that the same neural mechanisms that support the role of MTL in spatial navigation also support the formation of episodic memories. We propose an innovative set of experiments designed to directly test this hypothesis Our approach involves recording neural activity from the same neurons in the medial temporal lobe of marmoset monkeys in two contexts. One involves head-restrained subjects performing a recognition memory task typical of human experiments while in the other freely-moving subjects navigate spatial environments commonly used in studies of rodents. Our innovative approach will allow us to test – for the first time - whether the same neurons in primate medial temporal lobe support behaviors performed in tasks representative of these two research traditions. Aim 1 seeks to characterize recognition memory in marmosets using a task that – like spatial navigation – relies on incidental memory formation. Experiments in Aim 2 examine the role of the hippocampal CA fields and entorhinal cortex in spatial navigation, including the putative existence of place cells and grid cells, respectively. Aim 3 directly tests the principal question of this proposal by recording from the identical neurons while subjects perform the recognition memory task in Aim 1 and navigate spatial environments similar to studies in Aim 2.